Emerging techniques to treat corneal neovascularisation

Abstract

Neovascularisation is a major cause of visual loss in a number of ophthalmic diseases. This review aims to outline the basic regulators of vessel growth in corneal neovascularisation. An understanding of the underlying principles of physiological and pathophysiological vascular development helps to appreciate current approaches to prevent or treat corneal neovascularisation. Options for future interventions will be discussed in the light of recent evidence provided by animal models of corneal neovascularisation.

Preparation of arginine–glycine–aspartic acid-modified biopolymeric nanoparticles containing epigalloccatechin-3-gallate for targeting vascular endothelial cells to inhibit corneal neovascularization

“…2 Most subjects with myopia wear contact lenses, usually causing corneal hypoxia. In general, patients who sustain 1 Corneal NV may eventually result in blindness. 3 From these data, one can consider that a large population is at risk of developing corneal NV.…”

“…Most of these pathologies are associated with hypoxia, inflammation, and/or limbic barrier function. 1 In Taiwan, myopia is the most common eye disorder, diagnosed in 86% of the young population. 2 Most subjects with myopia wear contact lenses, usually causing corneal hypoxia.…”

Corneal Angiogenesis: Etiologies, Complications, and Management

“…The second type is stromal vessels, which results from alkaline injury or stromal keratitis (Figure 7). The third is deep vessels overlying Descemet's membrane, which can be associated with interstitial keratitis or HSV keratitis, or after deep anterior lamellar keratoplasty (Figure 8) [1,8,9,22]. Mixed paterns are often observed clini- A detailed clinical evaluation of corneal neovascularization, including extension (the number of quadrants involved) and depth, is crucial for treatment planning.…”

“…Diseases associated with corneal neovascularization include corneal graft rejection, inlammatory disorders, chemical burns, contact lens-related hypoxia, stromal ulceration, infectious keratitis, limbal stem cell deiciency, and congenital disease ( Table 1) [8][9][10].…”

Nanotechnology in Corneal Neovascularization Therapy—A Review

“…4 Corneal angiogenesis results from a wide variety of diseases and conditions, but most of these pathologies are associated with hypoxia, inflammation, and/or limbal barrier function. 5,6 Therefore, it is no surprise that the most affected populations are patients who wear contact lenses, have had corneal transplants, or suffer from an infectious disease of the eye. In general, patients who have sustained a traumatic eye injury (physical insult, infectious disease, or inflammation) are at risk of developing corneal angiogenesis, which can have detrimental effects on the patient's vision.…”