Emerging technologies and safety concerns: a condensed review of environmental life cycle risks in the nano-world

Glisovic, Srdjan; Pešić, Dušica; Stojiljković, Evica; Golubović, Tatjana; Krstić, Dragana; Praščević, Momir; Janković, Žarko

doi:10.1007/s13762-017-1367-2

Cited by 19 publications

(10 citation statements)

References 90 publications

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“…The commercial production of engineered nanomaterials (ENMs) is a steadily growing industry with increasing potential to impact human health as exposure to consumer products containing ENMs becomes more prevalent [1][2][3][4][5]. Studies addressing the safety of nanoscale particles indicate that their physicochemical properties (small size (<100 nm), chemical composition, electronic charge, large surface area to mass ratio, surface coating, potential for generating reactive oxygen species, and deep penetration) are capable of producing adverse effects on lung function including exacerbation of asthma and sensitization to common allergens [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Airway Exposure to Polyethyleneimine Nanoparticles Induces Type 2 Immunity by a Mechanism Involving Oxidative Stress and ATP Release

Srisomboon

Ohkura

Izutsu

et al. 2021

IJMS

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Polyethyleneimine (PEI) induced immune responses were investigated in human bronchial epithelial (hBE) cells and mice. PEI rapidly induced ATP release from hBE cells and pretreatment with glutathione (GSH) blocked the response. PEI activated two conductive pathways, VDAC-1 and pannexin 1, which completely accounted for ATP efflux across the plasma membrane. Moreover, PEI increased intracellular Ca2+ concentration ([Ca2+]i), which was reduced by the pannexin 1 inhibitor, 10Panx (50 μM), the VDAC-1 inhibitor, DIDS (100 μM), and was nearly abolished by pretreatment with GSH (5 mM). The increase in [Ca2+]i involved Ca2+ uptake through two pathways, one blocked by oxidized ATP (oATP, 300 μM) and another that was blocked by the TRPV-1 antagonist A784168 (100 nM). PEI stimulation also increased IL-33 mRNA expression and protein secretion. In vivo experiments showed that acute (4.5 h) PEI exposure stimulated secretion of Th2 cytokines (IL-5 and IL-13) into bronchoalveolar lavage (BAL) fluid. Conjugation of PEI with ovalbumin also induced eosinophil recruitment and secretion of IL-5 and IL-13 into BAL fluid, which was inhibited in IL-33 receptor (ST2) deficient mice. In conclusion, PEI-induced oxidative stress stimulated type 2 immune responses by activating ATP-dependent Ca2+ uptake leading to IL-33 secretion, similar to allergens derived from Alternaria.

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Section: Introductionmentioning

confidence: 99%

Airway Exposure to Polyethyleneimine Nanoparticles Induces Type 2 Immunity by a Mechanism Involving Oxidative Stress and ATP Release

Srisomboon

Ohkura

Izutsu

et al. 2021

IJMS

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“…A wide variety of nanomaterials has been introduced into our daily life to improve the properties of consumer products like clothes 1 , food 2 and cosmetics 3 . Despite a large body of studies, their potential influence on health is often poorly understood 4,5 . After its discovery in 2004, graphene has gained much attention as a novel two dimensional nanomaterial 6 .…”

Section: Introductionmentioning

confidence: 99%

The Low Toxicity of Graphene Quantum Dots is Reflected by Marginal Gene Expression Changes of Primary Human Hematopoietic Stem Cells

Fasbender

Zimmermann

Cadeddu

et al. 2019

Sci Rep

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Graphene quantum dots (GQDs) are a promising next generation nanomaterial with manifold biomedical applications. For real world applications, comprehensive studies on their influence on the functionality of primary human cells are mandatory. Here, we report the effects of GQDs on the transcriptome of CD34 + hematopoietic stem cells after an incubation time of 36 hours. Of the 20 800 recorded gene expressions, only one, namely the selenoprotein W, 1, is changed by the GQDs in direct comparison to CD34 + hematopoietic stem cells cultivated without GQDs. Only a meta analysis reveals that the expression of 1171 genes is weakly affected, taking into account the more prominent changes just by the cell culture. Eight corresponding, weakly affected signaling pathways are identified, which include, but are not limited to, the triggering of apoptosis. These results suggest that GQDs with sizes in the range of a few nanometers hardly influence the CD34 + cells on the transcriptome level after 36 h of incubation, thereby demonstrating their high usability for in vivo studies, such as fluorescence labeling or delivery protocols, without strong effects on the functional status of the cells.

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“…In the real world, environmentally aware product design frameworks and life cycle assessment strategies need to be set comprehensively for the enhancement of nanosafety to the environment. To specifically characterize and track nanomaterials in the environment, the most critical steps needed to investigate further in details are the formulation of nanomaterials databases to investigate the LCA of nanoproducts; gathering the real data of nanomaterials for the development of exposure limits of nanomaterials as well as formulation of advanced models; development of standardized protocols for handling nanomaterials in the workplace and the development of risk assessment methods to enhance their overall safety [179,180]. These steps will help assess the risks related to the application of nanomaterials in the real world, which hence can further enhance the safety in the workplace.…”

Section: Environmental Health and Safety Concernsmentioning

confidence: 99%

“…At the national level and international level, there is a great demand to set up a systematic strategy framework which can prevent risks and alleviate the safety concerns associated with each nanomaterial for both workers and customers [29,181,182]. Figure 16 below presents the national strategic framework which can provide useful information of each nanomaterial to the nano-industry to enhance the safety of workers and customers [180]. By considering the above EHS challenges, a suitable expertise group within government ministries could provide an appropriate framework for the safer and sustainable application of nanotechnology as shown in Figure 16.…”

Section: Environmental Health and Safety Concernsmentioning

confidence: 99%

“…By considering the above EHS challenges, a suitable expertise group within government ministries could provide an appropriate framework for the safer and sustainable application of nanotechnology as shown in Figure 16. This strategy utilizes useful information of experts to develop a national database system which can provide an EHS risk awareness for nanomaterial-developing nations [180,183]. This proactive technique can provide the expert information in a timely way to manufacturers and consumers effectively and efficiently.…”

Section: Environmental Health and Safety Concernsmentioning

confidence: 99%

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Nanotechnology in Transportation Vehicles: An Overview of Its Applications, Environmental, Health and Safety Concerns

Shafique

Luo

2019

Materials

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Nanotechnology has received increasing attention and is being applied in the transportation vehicle field. With their unique physical and chemical characteristics, nanomaterials can significantly enhance the safety and durability of transportation vehicles. This paper reviews the state-of-the-art of nanotechnology and how this technology can be applied in improving the comfort, safety, and speed of transportation vehicles. Moreover, this paper systematically examines the recent developments and applications of nanotechnology in the transportation vehicle industry, including nano-coatings, nano filters, carbon black for tires, nanoparticles for engine performance enchantment and fuel consumption reduction. Also, it introduces the main challenges for broader applications, such as environmental, health and safety concerns. Since several nanomaterials have shown tremendous performance and have been theoretically researched, they can be potential candidates for applications in future environmental friendly transportation vehicles. This paper will contribute to further sustainable research and greater potential applications of environmentally friendly nanomaterials in healthier transportation vehicles to improve the transportation industry around the globe.

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Emerging technologies and safety concerns: a condensed review of environmental life cycle risks in the nano-world

Cited by 19 publications

References 90 publications

Airway Exposure to Polyethyleneimine Nanoparticles Induces Type 2 Immunity by a Mechanism Involving Oxidative Stress and ATP Release

Airway Exposure to Polyethyleneimine Nanoparticles Induces Type 2 Immunity by a Mechanism Involving Oxidative Stress and ATP Release

The Low Toxicity of Graphene Quantum Dots is Reflected by Marginal Gene Expression Changes of Primary Human Hematopoietic Stem Cells

Nanotechnology in Transportation Vehicles: An Overview of Its Applications, Environmental, Health and Safety Concerns

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