Emerging Technologies in Prostate Cancer Radiation Therapy: Improving the Therapeutic Window

Biagioli, Matthew C.; Hoffe, Sarah E.

doi:10.1177/107327481001700403

Cited by 12 publications

(8 citation statements)

References 86 publications

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“…IMRT is an optimized high‐precision form of three‐dimensional conformal RT (3DCRT) [10] which allows better dose distributions in RT and improves the ability to conform the treatment volume to concave target shapes. The radiation beam is divided into individual beamlets so that varying doses can exploit differences in position of tumour vs normal tissue, assigning maximal doses to the targets at risk and minimal doses to normal tissue [45]. Using IMRT, radiation oncologists can increase doses homogeneously while respecting the tolerance doses in organs at risk [10].…”

Section: New Treatment Techniquesmentioning

confidence: 99%

Drivers for change in the management of prostate cancer – Guidelines and new treatment techniques

Wolff

Mason

2012

BJU International

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Clinical practice guidelines and new treatment techniques are of particular importance for the effective management of prostate cancer. In Europe, the European Association of Urology guidelines offer a regularly updated evidence‐based source of recommendations for the optimal treatment of prostate cancer. This review examines recent changes to guidelines highlighting developments in diagnosis, hormonal therapy in advanced and metastatic disease, bone protection, the definition of new terminology such as castrate‐resistant prostate cancer, treatment of relapse after hormonal therapy, and cytotoxic therapy for castrate‐resistant prostate cancer. The review also examines new surgical and radiotherapeutic developments in prostate cancer. This includes minimally invasive techniques such as robot‐assisted radical prostatectomy, which is becoming the surgical gold standard for clinically localized disease in many countries. Other promising techniques reviewed include cryosurgical ablation of the prostate, laser‐induced interstitial thermotherapy, vascular‐targeted photodynamic therapy, and high‐intensity focused ultrasound; with the exception of cryotherapy, these approaches are not currently recommended for routine clinical use. Finally, we will review the evidence supporting intensity modulated radiotherapy, an optimized high‐precision form of three‐dimensional conformal radiotherapy which aims to allow homogeneously increased radiation doses, without increased toxicity to healthy at‐risk organs. Novel techniques such as proton beam or carbon ion radiotherapy, which may offer improved and more localized dose distribution with reduced damage to normal tissue, are also examined.

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Section: New Treatment Techniquesmentioning

confidence: 99%

Drivers for change in the management of prostate cancer – Guidelines and new treatment techniques

Wolff

Mason

2012

BJU International

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“…2,6,7 This tight dose gradient allows an escalated tumoricidal dose to be delivered to the prostate while abutting or in close proximity to GI and GU structures. 3,9,10 IMRT has proven to lower rates of complications associated with normal tissue structures. 4,8,[11][12][13] Unlike 3-dimensional conformal radiotherapy, IMRT planning requires dose and volume objectives to be assigned to target tissues as well as critical structures.…”

Section: Introductionmentioning

confidence: 99%

Dosimetric comparison of intensity-modulated solutions for intact prostate cancer

Neill

2014

Medical Dosimetry

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“…Radiotherapy is the first line of treatment for a wide range of malignant tumors (Loiselle and Koh, 2010;Kang et al, 2010;Glenny et al, 2010;Zagar et al, 2010;Biagioli and Hoffe, 2010). Radiotherapy is used as a primary or adjuvant modality in combination with surgery, chemotherapy, hormone therapy and immunotherapy.…”

Section: Introductionmentioning

confidence: 99%

A review of the logistic role of l‐carnitine in the management of radiation toxicity and radiotherapy side effects

Khan

Alhomida

2011

J of Applied Toxicology

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Radiation therapy is a key modality in the treatment of different cancer types. Fatigue is the most common side effect of radiotherapy, while others include nausea, hair loss, skin irritation, anemia, infertility, cardiovascular disease, cognitive impairment and even the development of second cancers. Studies in experimental animals have shown protective effects of carnitine against exposure of various organs to ionizing radiation, whereas carnitine deficiency is known to enhance radiation-induced toxicity. This report summarizes the recent literature on the adverse effects of radiotherapy and the impact of radiation on carnitine homeostasis. Although some studies have demonstrated the prophylactic benefits of carnitine against the toxic effects of chemotherapy, the role of carnitine in the prognosis and management of cancer patients receiving radiotherapy is not clear and needs to be explored.

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Emerging Technologies in Prostate Cancer Radiation Therapy: Improving the Therapeutic Window

Abstract: Technological advancements have improved radiation dose delivery to the prostate and have reduced normal tissue toxicity. Randomized trials are warranted to ultimately evaluate clinical benefit and outcomes.

Cited by 12 publications

References 86 publications

Drivers for change in the management of prostate cancer – Guidelines and new treatment techniques

Drivers for change in the management of prostate cancer – Guidelines and new treatment techniques

Dosimetric comparison of intensity-modulated solutions for intact prostate cancer

A review of the logistic role of l‐carnitine in the management of radiation toxicity and radiotherapy side effects

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