Emerging Therapeutic Concepts I: ADEPT

Sharma, Surinder K.; Chester, Kerry; Bagshawe, K. D.

doi:10.1002/9783527619740.ch21

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Functional Supramolecular Protein Nanostructures (Pns) and T1

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“…However, applications are often limited by their low cellular uptake and proteolytic stability. The expression of fusion proteins consisting of enzymes and cell targeting entities such as antibodies (Abs), translocation domains of toxins and cell penetrating peptides (CPPs) has enabled cellular delivery of the enzyme cargo 211–214. Since the fusion takes place at the genetic level, it is not feasible to include chemically modified proteins or customize linkers equipped with various cleavage groups between the proteins in the design.…”

Section: Functional Supramolecular Protein Nanostructures (Pns) and Tmentioning

confidence: 99%