Emerging tissue engineering strategies for annulus fibrosus therapy

Zhang, Anran; Cheng, Zhangrong; Chen, Yuhang; Shi, Pengzhi; Gan, Weikang; Zhang, Yukun

doi:10.1016/j.actbio.2023.06.012

Cited by 17 publications

(7 citation statements)

References 133 publications

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“…Then, the intervertebral spaces of coccygeal vertebrae (Co) were exposed. The rats were assigned to the following groups [ 1 ]: control group (without surgery) [ 2 ]; injured group (with surgery) [ 3 ]; T-MN group (with surgery and fitting of T-MN) [ 4 ]; T-MN @EXO group (with surgery and fitting of T-MN @EXO ); and [ 5 ] T-MN @EXO@miR−378 group (with surgery and fitting of T-MN @EXO@378 ). We located the third and fourth coccygeal discs were located counting the vertebrae from the sacral region.…”

Section: Methodsmentioning

confidence: 99%

“…The IVD consists of a cartilage endplate, an outer annulus fibrosus (AF), and an inner nucleus pulposus (NP) [ 4 ]. AF prevents the radial expansion of the NP disc by generating large circumferential stresses and resisting large tensile and compressive strains [ 5 ]. However, trauma or chronic strain may lead to tearing of the AF to varying degrees, eventually resulting in AF rupture.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Thread-structural microneedles loaded with engineered exosomes for annulus fibrosus repair by regulating mitophagy recovery and extracellular matrix homeostasis

Hu,

Zhu,

Xing

et al. 2024

Bioactive Materials

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Thread-structural microneedles loaded with engineered exosomes for annulus fibrosus repair by regulating mitophagy recovery and extracellular matrix homeostasis

Hu,

Zhu,

Xing

et al. 2024

Bioactive Materials

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“…Therefore, physiological osmotic pressure can easily dissipate any mechanical force transmitted through the spine ( 11 , 12 ). The AF is a layered structure mainly composed of type I collagen ( 13 , 14 ), whereas the CEP is composed of transparent cartilage located between IVD soft tissue and the vertebral bone structures ( 15 , 16 ). The CEP is crucial in the maintenance of mechanical integrity and nutrient exchange of the IVD.…”

Section: Introductionmentioning

confidence: 99%

From hyperglycemia to intervertebral disc damage: exploring diabetic-induced disc degeneration

Li,

Du,

Huang

et al. 2024

Front. Immunol.

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The incidence of lumbar disc herniation has gradually increased in recent years, and most patients have symptoms of low back pain and nerve compression, which brings a heavy burden to patients and society alike. Although the causes of disc herniation are complex, intervertebral disc degeneration (IDD) is considered to be the most common factor. The intervertebral disc (IVD) is composed of the upper and lower cartilage endplates, nucleus pulposus, and annulus fibrosus. Aging, abnormal mechanical stress load, and metabolic disorders can exacerbate the progression of IDD. Among them, high glucose and high-fat diets (HFD) can lead to fat accumulation, abnormal glucose metabolism, and inflammation, which are considered important factors affecting the homeostasis of IDD. Diabetes and advanced glycation end products (AGEs) accumulation- can lead to various adverse effects on the IVD, including cell senescence, apoptosis, pyroptosis, proliferation, and Extracellular matrix (ECM) degradation. While current research provides a fundamental basis for the treatment of high glucose-induced IDD patients. further exploration into the mechanisms of abnormal glucose metabolism affecting IDD and in the development of targeted drugs will provide the foundation for the effective treatment of these patients. We aimed to systematically review studies regarding the effects of hyperglycemia on the progress of IDD.

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“…[ 18 ] Hence, in order to counter the reduced permeability caused by avascular dense connective tissues (e.g., AF tissue), the focus has turned to gas therapy within the realm of research. [ 19 ] Simultaneously, it occurred that microenvironment deterioration (e.g. oxidative stress elevation, inflammation increases, and immune cell infiltration) and limited tissue regeneration (e.g.…”

Section: Introductionmentioning

confidence: 99%

Accurate Spatio‐Temporal Delivery of Nitric Oxide Facilitates the Programmable Repair of Avascular Dense Connective Tissues Injury

Feng,

Su,

Liu

et al. 2024

Adv Healthcare Materials

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Avascular dense connective tissues (e.g., the annulus fibrosus (AF) rupture, the meniscus tear, and tendons and ligaments injury) repair remains a challenge due to the “biological barrier” that hinders traditional drug permeation and limits self‐healing of the injured tissue. Here, accurate delivery of nitric oxide (NO) to penetrate the “AF biological barrier” is achieved thereby enabling programmable AF repair. NO‐loaded BioMOFs are synthesized and mixed in a modified polyvinyl alcohol and PCL‐composited electrospun fiber membrane with excellent reactive oxygen species‐responsive capability (LN@PM). The results show that LN@PM could respond to the high oxidative stress environment at the injured tissue and realize continuous and substantial NO release. Based on low molecular weight and lipophilicity, NO could penetrate through the “biological barrier” for accurate AF drug delivery. Moreover, the dynamic characteristics of the LN@PM reaction can be matched with the pathological microenvironment to initiate programmable tissue repair including sequential remodeling microenvironment, reprogramming the immune environment, and finally promoting tissue regeneration. This tailored programmable treatment strategy that matches the pathological repair process significantly repairs AF, ultimately alleviating intervertebral disc degeneration. This study highlights a promising approach for avascular dense connective tissue treatment through intelligent NO release, effectively overcoming “AF biological barriers” and programmable treatment.

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Emerging tissue engineering strategies for annulus fibrosus therapy

Cited by 17 publications

References 133 publications

Thread-structural microneedles loaded with engineered exosomes for annulus fibrosus repair by regulating mitophagy recovery and extracellular matrix homeostasis

Thread-structural microneedles loaded with engineered exosomes for annulus fibrosus repair by regulating mitophagy recovery and extracellular matrix homeostasis

From hyperglycemia to intervertebral disc damage: exploring diabetic-induced disc degeneration

Accurate Spatio‐Temporal Delivery of Nitric Oxide Facilitates the Programmable Repair of Avascular Dense Connective Tissues Injury

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