Emerging trends and future opportunities for coumarin-heterocycle conjugates as antibacterial agents

Mustafa, Yasser Fakri

doi:10.1016/j.rechem.2023.101151

Cited by 27 publications

(6 citation statements)

References 60 publications

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“…The second is that the phytocoumarins examined had the same sequence of action as the three previously researched impacts, even if there are very few variations in their IC 50 values. This data may provide some degree of confirmation that the GSBP seed phytocoumarins′ ability to reduce oxidative stress is related to their anti‐inflammatory, anti‐cancer, and antidiabetic properties [79–81] …”

Section: Resultsmentioning

confidence: 62%

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Unveiling the Biomedical Applications of Novel Coumarins Isolated From Capsicum Annuum L. Seeds by a Multivariate Extraction Technique

Younes,

Mustafa

2024

Chemistry & Biodiversity

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For the first time, kinetic thermomagnetic extraction is a novel approach presented in this work. It required the application of four distinct variables: rotation speed (50, 75, and 100 rpm), magnetic field (0.8, 1.2, and 1.6 T), time interval (30, 60, and 90 min), and temperature (45, 55, and 65°C). Numerous phytochemical categories were detected in the 81 crude chloroform extracts of green sweet bell pepper seeds that were collected, according to phytochemical analysis. Nine extracts were discovered to be linked to the coumarin chemical class and to have the same two extraction parameters: a 90‐minute extraction duration and a 55°C extraction temperature. To enable their coumarin contents to be chemically separated and chromatographically purified, two of these extracts containing coumarin were chosen. Four new phytocoumarins have been identified and their molecular structures distinguished using FTIR spectra, 1H‐NMR, 13C‐NMR, and mass analysis. The results demonstrated that the extracted phytocoumarins have exceptional oxidative stress‐mitigating characteristics, ranging from 71.51 to 81.48%, when compared to a positive control. Furthermore, they showed excellent cytotoxicity against the test malignant populations (IC50 values of 46.76–81.45 μg/ml). The isolates need to be taken into account as dual COX‐2/5‐LOX antagonists because they also showed a selective anti‐inflammatory effect

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Section: Resultsmentioning

confidence: 62%

“…This data may provide some degree of confirmation that the GSBP seed phytocoumarins' ability to reduce oxidative stress is related to their anti-inflammatory, anti-cancer, and antidiabetic properties. [79][80][81]…”

Section: Anticancer Impactmentioning

confidence: 99%

Unveiling the Biomedical Applications of Novel Coumarins Isolated From Capsicum Annuum L. Seeds by a Multivariate Extraction Technique

Younes,

Mustafa

2024

Chemistry & Biodiversity

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“…The management of PJI leads to the need for a multifaceted approach and local antimicrobial agents have emerged as a very important component in the battle against this condition (Mustafa et al, 2023). The adoption of local antibacterial agents has effectively revolutionized the treatment of PJI this is by representing critical advancement in the management of the condition.…”

Section: Local Antimicrobial Agentsmentioning

confidence: 99%

Systematic Review on the Current Situation and Development of Local Antimicrobial Agents in Revision Arthroplasty for Periprosthetic Joint Infection (PJI)

Jama,

Cao,

et al. 2024

jhms

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health, behavioral health, health policy, health service, health education, health economics, medical ethics, health protection, environmental health, and equity in health. As the journal is Open Access, it ensures high visibility and the increase of citations for all research articles published. The Journal of Health and Medical Sciences aims to facilitate scholarly work on recent theoretical and practical aspects of Health and Medical Sciences.

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“…The number of cases of fungal infections is rising, along with an increase in the patient groups at risk. [92,93] Patients with fungal infections have a significant death rate because it is challenging Figure 13. Some of the bacterial resistance mechanisms that lead to multidrug-resistant microorganisms.…”

Section: Antifungal Capacity Of Pdcsmentioning

confidence: 99%

Plant‐Derived Coumarins: A Narrative Review of Their Structural and Biomedical Diversity

Younes,

Mustafa

2024

Chemistry & Biodiversity

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Plant‐derived coumarin (PDC) is a naturally occurring heterocyclic backbone that belongs to the benzopyrone family. PDC and its based products are characterized by low toxicity and high distribution in a variety of herbal treatments that have numerous therapeutic potentials. These include anticoagulants, antibacterials, anti‐inflammatory agents, anticancer agents, antioxidants, and others. So, it may be appropriate to investigate the qualities and potential bioactivities of PDCs. This article provides an overview of the biomedical potentials, availability, and clinical use possibilities of PDCs, with a focus on their important modes of action, using information on various pharmacological qualities discovered. The data used in this study came from published research between 2015 and 2023. We reviewed a selection of databases, including PubMed, Scopus, Web of Science, and Google Scholar, during that period. In conclusion, because of their abundance in medicinal plants, the clinical biochemistry attributes of PDCs are currently of interest. In a variety of medical specialties, PDCs serve a useful role as therapeutic agents.

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Emerging trends and future opportunities for coumarin-heterocycle conjugates as antibacterial agents

Cited by 27 publications

References 60 publications

Unveiling the Biomedical Applications of Novel Coumarins Isolated From Capsicum Annuum L. Seeds by a Multivariate Extraction Technique

Unveiling the Biomedical Applications of Novel Coumarins Isolated From Capsicum Annuum L. Seeds by a Multivariate Extraction Technique

Systematic Review on the Current Situation and Development of Local Antimicrobial Agents in Revision Arthroplasty for Periprosthetic Joint Infection (PJI)

Plant‐Derived Coumarins: A Narrative Review of Their Structural and Biomedical Diversity

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