Emerging trends and thematic evolution of immunotherapy for glioma based on the top 100 cited articles

Abstract

PurposeThis study aims to depict the scientific advancements in immunotherapy for glioma by analyzing the top 100 most frequently cited articles over the past 20 years.MethodsThe top 100 most influential papers in immunotherapy for glioma were identified from the Web of Science Core Collection. Citations, countries/regions, institutions, journals, authorships, keywords, and references were extracted and analyzed by CiteSpace, VOSviewer, R software, and an online bibliometric platform.ResultsThe United States possessed a robust global presence, leading in terms of publications and maintaining strong collaborative ties with numerous countries. The institution that made the greatest contributions was Duke University, with 16 papers. Heimberger AB, Sampson JH, and Reardon DA secured the top three positions with 15, 12, and 11 papers, respectively. “Macrophage ontogeny,” “microglia,” “polarization,” “mass cytometry,” “tumor mutation burden,” “sensitivity,” “msh6,” “pd-1 blockade,” and “dna repair” were the recent hot keywords. “Microglia” and “polarization” as the emerging research directions should be given more consideration.ConclusionsThis is the first bibliometric analysis to identify the top 100 papers on immunotherapy for glioma. “Microglia” and “polarization” will be hot spots for future research. The clinical efficacy of glioma immunotherapy is not yet satisfactory, and there is an urgent need to search for more tumor specific antigens and targets that can assist in early diagnosis, precise treatment, prognosis, and recurrence prediction of glioma.

The top 100 most cited articles on mucopolysaccharidoses: a bibliometric analysis

“…The number of citations of the same article in different databases is not the same, in order to avoid inconsistency in the results, so we choose only one database to search (Zhang et al, 2023). The Web of Science Core Collection (WoSCC) is the most extensively utilized database in academic research (L. Chen et al, 2023;Liu et al, 2024;Zhou et al, 2023), so we searched the WoSCC for articles related to MPS and sorted them in descending order of citations to filter the top 100 most-cited articles. The search was performed using the following terms: TI=(mucopolysaccharidosis) OR TI=(Mucopolysaccharidoses) OR TI=(Mucopolysaccharide Diseases) OR TI=(Mucopolysaccharides) OR TI=(MPS) OR TI=(Hurler syndrome) OR TI= (Hunter syndrome) OR TI=(Sanfilippo syndrome) OR TI=(Morquio syndrome) OR TI=(Marateaux-Lamy syndrome) OR TI=(Sly syndrome) OR TI=(Hyaluronidase deficiency), the language is set to English, the type of article is not limited, and the period from 1 January 1900 to 8 November 2023.…”