Emerging Trends in Deciphering the Pathogenesis of Human Diseases through Genetic Analysis

Wang, David Q.–H.

doi:10.3390/genes12010096

Cited by 1 publication

(1 citation statement)

References 9 publications

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“…CCKs in the blood circulation are present as four peptides with chains of different lengths, namely, CCK octapeptide (CCK-8), CCK-33, CCK-39 and CCK-58, among which CCK-8 has the greatest physiological effect on gallbladder contraction[ 2 ]. CCK has been reported to regulate guinea pig ileal contraction via CCK-A and CCK-B receptors[ 5 ], but CCK modulates guinea pig gallbladder contraction through only CCK-A receptors[ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Expression and functional study of cholecystokinin-A receptors on the interstitial Cajal-like cells of the guinea pig common bile duct

Xu,

Ma,

Huang

et al. 2023

World J Gastroenterol

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Intraductal papillary neoplasms of the bile duct (IPNBs) represent a rare variant of biliary tumors characterized by a papillary growth within the bile duct lumen. Since their first description in 2001, several classifications have been proposed, mainly based on histopathological, radiological and clinical features, although no specific guidelines addressing their management have been developed. Bile duct neoplasms generally develop through a multistep process, involving different precursor pathways, ranging from the initial lesion, detectable only microscopically, i.e. biliary intraepithelial neoplasia, to the distinctive grades of IPNB until the final stage represented by invasive cholangiocarcinoma. Complex and advanced investigations, mainly relying on magnetic resonance imaging (MRI) and cholangioscopy, are required to reach a correct diagnosis and to define an adequate bile duct mapping, which supports proper treatment. The recently introduced subclassifications of types 1 and 2 highlight the histopathological and clinical aspects of IPNB, as well as their natural evolution with a particular focus on prognosis and survival. Aggressive surgical resection, including hepatectomy, pancreaticoduodenectomy or both, represents the treatment of choice, yielding optimal results in terms of survival, although several endoscopic approaches have been described. IPNBs are newly recognized preinvasive neoplasms of the bile duct with high malignant potential. The novel subclassification of types 1 and 2 defines the histological and clinical aspects, prognosis and survival. Diagnosis is mainly based on MRI and cholangioscopy. Surgical resection represents the mainstay of treatment, although endoscopic resection is currently applied to nonsurgically fit patients. New frontiers in genetic research have identified the processes underlying the carcinogenesis of IPNB, to identify targeted therapies.

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Section: Introductionmentioning

confidence: 99%

Expression and functional study of cholecystokinin-A receptors on the interstitial Cajal-like cells of the guinea pig common bile duct

Xu,

Ma,

Huang

et al. 2023

World J Gastroenterol

View full text Add to dashboard Cite

show abstract

Emerging Trends in Deciphering the Pathogenesis of Human Diseases through Genetic Analysis

Abstract: Any changes in gene expression or protein functions can cause abnormal anatomical, physiological, biochemical, and behavioral modifications in human beings, which can lead to disease [...]

Cited by 1 publication

References 9 publications

Expression and functional study of cholecystokinin-A receptors on the interstitial Cajal-like cells of the guinea pig common bile duct

Expression and functional study of cholecystokinin-A receptors on the interstitial Cajal-like cells of the guinea pig common bile duct

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