Emerging Trends in Heart Valve Engineering: Part III. Novel Technologies for Mitral Valve Repair and Replacement

Kheradvar, Arash; Groves, Elliott M.; Simmons, Craig A.; Griffith, Boyce E.; Alavi, S. Hamed; Tranquillo, Robert T.; Dasi, Lakshmi Prasad; Falahatpisheh, Ahmad; Grande-Allen, K. Jane; Goergen, Craig J.; Mofrad, Mohammad R. K.; Baaijens, Fpt Frank; Čanić, Sunčica; Little, Stephen H.

doi:10.1007/s10439-014-1129-y

Cited by 38 publications

(29 citation statements)

References 59 publications

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“…(52) Specific anatomic considerations are fundamental for the successful implementation of such devices, yet the principle anatomic features can vary significantly between prospective patients. The mitral annular area, anterior mitral leaflet length, aortic-mitral angle, LVOT area, and specific sub-valvular and annular calcium depositions are just some of the considerations.…”

Section: Cardiovascular Applicationsmentioning

confidence: 99%

Cardiac 3D Printing and its Future Directions

Vukicevic

Mosadegh

Min

et al. 2017

JACC: Cardiovascular Imaging

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448

284

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3D printing is at the crossroads of printer and materials engineering; non-invasive diagnostic imaging; computer aided design (CAD); and structural heart intervention. Cardiovascular applications of this technology development include the use of patient-specific 3D models for medical teaching, exploration of valve and vessel function, surgical and catheter-based procedural planning, and early work in designing and refining the latest innovations in percutaneous structural devices. In this review we discuss the methods and materials being used for 3D printing today. We discuss the basic principles of clinical image segmentation including co-registration of multiple imaging datasets to create an anatomic model of interest. With applications in congenital heart disease, coronary artery disease, and in surgical and catheter-based structural disease – 3D printing is a new tool that is challenging how we image, plan, and carry out cardiovascular interventions.

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Section: Cardiovascular Applicationsmentioning

confidence: 99%

Cardiac 3D Printing and its Future Directions

Vukicevic

Mosadegh

Min

et al. 2017

JACC: Cardiovascular Imaging

Self Cite

448

284

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“…1) of Sorin Biomedica Cardio (Italy). Transplantation of such a valve with a diameter d  25 mm is performed mainly in the left ventricle of the heart with aortic or mitral valve prosthetics [13,14]. In research, a mechanical bileaflet valve was placed in the mitral valve position between the left atrium and the left ventricular chamber.…”

Section: Experimental Setup and Research Techniquementioning

confidence: 99%

Effect of Fluid Viscosity on Noise of Bileaflet Prosthetic Heart Valve

Voskoboinick¹,

Redaelli²,

Chertov³

et al. 2017

Research Bulletin of the National Technical University of Ukraine "Kyiv Politechnic Institute"

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Background. Numerical simulation and experimental research have been used as powerful tools to understand and predict the behavior and mechanics of the operation of natural heart valves and their prostheses in natural and pathological conditions. Such studies help to evaluate the effectiveness of the valves, their design and the results of surgical procedures, to diagnose healthy and impaired function of the heart valves. There is an actual problem in creating more reliable methods and tools for the operation diagnostics of mechanical heart valves. Objective. The aim of the research is to investigate the effect of fluid viscosity on the hydroacoustic characteristics of jets that flow from a semi-closed and open mechanical bileaflet heart valve. To study the possibility of using hydroacoustic measuring instruments as diagnostic equipment for determining the working conditions of the bileaflet prosthetic heart valve. Methods. The experimental research was carried out by means of hydroacoustic measurements of the hydrodynamic noise in the near wake of the side and central jets of the glycerin solution and the pure water flow downstream of the prosthetic bileaflet heart valve. Results. The effect of fluid viscosity on the hydroacoustic characteristics of the jets that flow from a semi-closed and open mechanical bileaflet heart valve has been experimentally determined. Integral and spectral characteristics of the hydrodynamic noise of jets of the glycerin solution and the pure water flow downstream of the bileaflet mitral heart valve for different fluid rate were detected. Conclusions. In the stream conditions of pure water, the integral characteristics of the pressure field are lower than in stream conditions of the aqueous glycerin solution. As the glycerin concentration in the solution increases, increase average pressures and especially RMS pressure fluctuations. The spectral levels of the hydrodynamic noise in the near wake of the side jet of the glycerin solution are lower than for water flow in the frequency ranges from 1 to 7-8 Hz and from 100 to 1000 Hz for fluid rate 5 l/min. For higher fluid rates, the spectral components of the hydrodynamic noise in the near wake of the side jet of the glycerin solution of the semi-closed mitral valve are higher than that for the pure water. The greatest difference (1.5-1.8 times) in the spectral levels is observed in the frequency range from 10 to 100 Hz for the fluid rate 15 l/min.

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“…[84] For a summary of recent progress in engineering approaches to valve disease, we refer the reader to a recent three-part review. [85–87]…”

Section: Valves and Devicesmentioning

confidence: 99%

Computational modeling and engineering in pediatric and congenital heart disease

Marsden¹,

Feinstein

2015

Current Opinion in Pediatrics

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Purpose of review Recent methodological advances in computational simulations are enabling increasingly realistic simulations of hemodynamics and physiology, driving increased clinical utility. We review recent developments in the use of computational simulations in pediatric and congenital heart disease, describe the clinical impact in modeling in single ventricle patients, and provide an overview of emerging areas. Recent Findings Multiscale modeling combining patient specific hemodynamics with reduced order (i.e. mathematically and computationally simplified) circulatory models has become the defacto standard for modeling local hemodynamics and “global” circulatory physiology. We review recent advances that have enabled faster solutions, discuss new methods, (e.g. fluid structure interaction and uncertainty quantification), which lend realism both computationally and clinically to results, highlight novel computationally-derived surgical methods for single ventricle patients, and discuss areas in which modeling has begun to exert its influence including Kawasaki disease, fetal circulation, tetralogy of Fallot, (and pulmonary tree), and circulatory support. Summary Computational modeling is emerging as a crucial tool for clinical decision-making and evaluation of novel surgical methods and interventions in pediatric cardiology and beyond. Continued development of modeling methods, with an eye towards clinical needs, will enable clinical adoption in a wide range of pediatric and congenital heart diseases.

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Emerging Trends in Heart Valve Engineering: Part III. Novel Technologies for Mitral Valve Repair and Replacement

Cited by 38 publications

References 59 publications

Cardiac 3D Printing and its Future Directions

Cardiac 3D Printing and its Future Directions

Effect of Fluid Viscosity on Noise of Bileaflet Prosthetic Heart Valve

Computational modeling and engineering in pediatric and congenital heart disease

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