Emerging Trends in the Application of Green Synthesized Biocompatible ZnO Nanoparticles for Translational Paradigm in Cancer Therapy

Abstract

Zinc oxide nanomaterials have been the cynosure of this decade because of their immense potential in different biomedical applications. It includes their usage in the prognosis and treatment of different infectious and cellular diseases, owing to their peculiar physiochemical properties such as variable shape, size, and surface charge etc. Increasing demand and usage of the ZnO nanomaterials raise concerns about their cellular and molecular toxicity and their biocompatibility with human cells. This review comprehensively details their physiochemical properties for usage in biomedical applications. Furthermore, the toxicological concerns of ZnO nanomaterials with different types of cellular systems have been reviewed. Moreover, the biomedical and biocompatible efficacy of ZnO nanomaterials for cancer specific pathways has been discussed. This review offers insights into the current scenario of ZnO nanomaterials usage and signifies their potential future extension usage on different types of biomedical and environmental applications.

Functionalized ZnO-Based Nanocomposites for Diverse Biological Applications: Current Trends and Future Perspectives

“…Zinc oxide nanocomposites have garnered significant attention in the realm of biological applications due to their unique properties and versatile characteristics. The inherent biocompatibility of ZnO makes it an attractive candidate for diverse biomedical purposes, such as drug delivery, imaging and biosensing [ 49 , 159 , 160 ]. The high surface area-to-volume ratio of ZnO nanocomposites allows efficient drug loading, enabling targeted and controlled release for therapeutic applications.…”

Surface engineered nanohybrids in plasmonic photothermal therapy for cancer: Regulatory and translational challenges

“…Reactive oxygen species (ROS) can be produced by zinc oxide (ZnO) nanoparticles when they encounter light and have good photocatalytic qualities. When the ZnO NPs are exposed to light, they release ROS, which can provide protection from harm to healthy tissues and specifically destroy cancer cells through oxidative stress 75 . A high toxicity effect was observed at concentrations of 4.7 μg/mL-1, as discovered by testing the in vitro cytotoxicity of various concentrations of flaxseed-derived iron oxide nanoparticles (IONPs) against MCF-7 cells.…”

ZnO based 0–3D diverse nano-architectures, films and coatings for biomedical applications

“…Although ZnO has been researched extensively, thin films composed of 0–3D nano-architectures with promising thin film device bio-nanotechnology applications have rarely been reviewed. For example, several recent published reviews are focused on green synthesis of ZnO materials and biomedical applications 38–44 with major emphasis on the eco-friendly approach of the green synthesis route. Several reviews are focused on some particular biomedical applications such as antibacterial, 45–48 wound healing, 49 cancer therapy, 40,48 drug delivery, 50 bioimaging, 47,51 etc .…”

“…For example, several recent published reviews are focused on green synthesis of ZnO materials and biomedical applications 38–44 with major emphasis on the eco-friendly approach of the green synthesis route. Several reviews are focused on some particular biomedical applications such as antibacterial, 45–48 wound healing, 49 cancer therapy, 40,48 drug delivery, 50 bioimaging, 47,51 etc . Some reviews are focused on ZnO/polymer nanocomposites and their biomedical applications.…”