Emerging Trends in the Delivery of Resveratrol by Nanostructures: Applications of Nanotechnology in Life Sciences

Chopra, Hitesh; Bibi, Shabana; Islam, Fahadul; Ahmad, Syed Umair; Olawale, Oluwaseyi Abraham; Alhumaydhi, Fahad A.; Marzouki, Riadh; Baig, Atif Amin; Emran, Talha Bin

doi:10.1155/2022/3083728

Cited by 32 publications

(24 citation statements)

References 156 publications

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“…Synthesized nanoparticles have multiapplication in cosmetics, packing, coating, biomedicine, etc. [3,62]. These applications depend on prepared nanoparticles having uniform composition, size, shape, and stability [24,[63][64][65].…”

Section: Discussionmentioning

confidence: 99%

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Green Synthesis of Gold Nanoparticles Using Extract of Pistacia chinensis and Their In Vitro and In Vivo Biological Activities

Alhumaydhi

2022

Journal of Nanomaterials

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The synthesis of metal nanoparticles by using plant extracts is previously explored in phytomedicines. Nanobiotechnology has many applications, including cosmetic, packing, coating, biomedicine, and enhanced biological activity. Keeping in view the importance of Pistacia chinensis, its gold nanoparticles (AuNPs) have been synthesized by the eco-friendless and cost-effective method. In this study, the synthesized nanoparticles were characterized by advanced techniques such as UV-visible spectroscopy, Fourier transform infrared (FT-IR), and atomic force microscope (AFM) analysis. The biological activities of these synthesized nanoparticles were examined in vitro by measuring the enzymatic inhibition potential on urease and carbonic anhydrase and in vivo by determining the analgesic and sedative activities. The UV spectrum indicated various peaks at the range of 530-550 nm, showing nanoparticles formation. The FT-IR spectroscopy of the extracts and AuNPs indicated the presence of NH, C═N, and N═O in the extract involved in the nanoparticles synthesis. The size of nanoparticles was determined by AFM analysis. The AFM showed that the nanoparticles range from 10 to 100 nm and are almost spherical in shape. The synthesized AuNPs exhibited significant urease inhibition potential with an IC50 value of 44.98. Similarly, the nanoparticles exhibited good carbonic anhydrase inhibition with an IC50 value of 53.54 against acetazolamide having IC50 0.13. Pistacia chinensis extract and its AuNPs exhibited excellent attenuation p < 0.01 in acetic acid-induced writhing model at a dose of 15 mg/kg. The synthesized nanoparticles showed a significant sedative effect p < 0.001 compared to the standard drug. This research work has developed a green method to synthesize nanoparticles by using Pistacia chinensis extract and directed the researcher to purify active phytochemicals from Pistacia chinensis involved in nanoparticles synthesized.

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Section: Discussionmentioning

confidence: 99%

“…Application of nanotechnology has found to be of significant importance in different fields such as imaging, sensing, and biomedical sciences [1][2][3][4]. It has also a broad-spectrum usage in several areas including cosmetics, energy, electronics, food, agriculture, and biomedicine [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Gold Nanoparticles Using Extract of Pistacia chinensis and Their In Vitro and In Vivo Biological Activities

Alhumaydhi

2022

Journal of Nanomaterials

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“…It also reduces the ability of NF-κB to bind to DNA. RES inhibits tumor growth by lowering the binding activity of this factor, which increases the transcription of genes that promote tumor cell proliferation [ 85 , 127 , 128 ]. RES decreases intracellular ROS, mitochondrial membrane potential, mTOR, RP-S6, and 4EBP1 phosphorylation.…”

Section: Natural Compounds Against Breast Cancermentioning

confidence: 99%

Natural Small Molecules in Breast Cancer Treatment: Understandings from a Therapeutic Viewpoint

Islam

Nafady

et al. 2022

Molecules

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Breast cancer (BrCa) is the most common malignancy in women and the second most significant cause of death from cancer. BrCa is one of the most challenging malignancies to treat, and it accounts for a large percentage of cancer-related deaths. The number of cases requiring more effective BrCa therapy has increased dramatically. Scientists are looking for more productive agents, such as organic combinations, for BrCa prevention and treatment because most chemotherapeutic agents are linked to cancer metastasis, the resistance of the drugs, and side effects. Natural compounds produced by living organisms promote apoptosis and inhibit metastasis, slowing the spread of cancer. As a result, these compounds may delay the spread of BrCa, enhancing survival rates and reducing the number of deaths caused by BrCa. Several natural compounds inhibit BrCa production while lowering cancer cell proliferation and triggering cell death. Natural compounds, in addition to therapeutic approaches, are efficient and potential agents for treating BrCa. This review highlights the natural compounds demonstrated in various studies to have anticancer properties in BrCa cells. Future research into biological anti-BrCa agents may pave the way for a new era in BrCa treatment, with natural anti-BrCa drugs playing a key role in improving BrCa patient survival rates.

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“…One of the most significant advancements in nanotechnology and materials science is the creation of engineered nanomaterials ( Mu et al, 2021 ; Sun et al, 2021 ). Nanotechnology has penetrated various fields such as drug delivery and other biomedical applications ( Chopra et al, 2021a , 2021b , 2022 ; Singla et al, 2021 ; Bhattacharya et al, 2022 ). Moving these things out of the lab and into the real world is the only way to bring them to life.…”

Section: Introductionmentioning

confidence: 99%

Green Metallic Nanoparticles: Biosynthesis to Applications

Chopra

Bibi

Singh

et al. 2022

Front. Bioeng. Biotechnol.

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Current advancements in nanotechnology and nanoscience have resulted in new nanomaterials, which may pose health and environmental risks. Furthermore, several researchers are working to optimize ecologically friendly procedures for creating metal and metal oxide nanoparticles. The primary goal is to decrease the adverse effects of synthetic processes, their accompanying chemicals, and the resulting complexes. Utilizing various biomaterials for nanoparticle preparation is a beneficial approach in green nanotechnology. Furthermore, using the biological qualities of nature through a variety of activities is an excellent way to achieve this goal. Algae, plants, bacteria, and fungus have been employed to make energy-efficient, low-cost, and nontoxic metallic nanoparticles in the last few decades. Despite the environmental advantages of using green chemistry-based biological synthesis over traditional methods as discussed in this article, there are some unresolved issues such as particle size and shape consistency, reproducibility of the synthesis process, and understanding of the mechanisms involved in producing metallic nanoparticles via biological entities. Consequently, there is a need for further research to analyze and comprehend the real biological synthesis-dependent processes. This is currently an untapped hot research topic that required more investment to properly leverage the green manufacturing of metallic nanoparticles through living entities. The review covers such green methods of synthesizing nanoparticles and their utilization in the scientific world.

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Emerging Trends in the Delivery of Resveratrol by Nanostructures: Applications of Nanotechnology in Life Sciences

Cited by 32 publications

References 156 publications

Green Synthesis of Gold Nanoparticles Using Extract of Pistacia chinensis and Their In Vitro and In Vivo Biological Activities

Green Synthesis of Gold Nanoparticles Using Extract of Pistacia chinensis and Their In Vitro and In Vivo Biological Activities

Natural Small Molecules in Breast Cancer Treatment: Understandings from a Therapeutic Viewpoint

Green Metallic Nanoparticles: Biosynthesis to Applications

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