Emerging two-dimensional monoelemental materials (Xenes) for biomedical applications

Tao, Wei; Kong, Na; Ji, Xiaoyuan; Zhang, Yupeng; Sharma, Amit; Ouyang, Jun; Qi, Baokun; Wang, Junqing; Xie, Ni; Kang, Chulhun; Zhang, Han; Farokhzad, Omid C.; Kim, Jong Seung

doi:10.1039/c8cs00823j

Cited by 536 publications

(319 citation statements)

References 54 publications

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“…As a complementary alternative to traditional treatments (such as chemotherapy, radiotherapy, and surgical treatment), nanomedicine, particularly nano‐oncology, has recently become a promising clinical field. To date, various nanoparticles, including liposomes, proteins, mesoporous silica, quantum dots, upconversion materials, metallic oxides, carbon‐based materials, MXenes, and metal–organic frameworks (MOFs), have been applied in cancer nanotherapeutics. However, the design of new nanomaterial‐based nanomedicines with high biocompatibility and minimal side‐effects remains challenging.…”

Section: Introductionmentioning

confidence: 99%

Covalent Organic Frameworks (COFs) for Cancer Therapeutics

Guan

Zhou

et al. 2020

Chemistry A European J

153

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As newly emerged crystalline porous materials, covalent organic frameworks (COFs) possess fascinating structures and some specific features such as modularity,c rystallinity,p orosity,s tability, versatility,a nd biocompatibility.B esides adsorption/separation, sensing, catalysis, and energy applications, COFs have recently shown ap romise in biomedical applications. This contribution provides an overview of the recent developments of COF-based medicines in cancer therapeutics, including drug delivery,p hotodynamic therapy( PDT), photothermal therapy (PTT), and combined therapy. Furthermore, the major challengesa nd developing trends in this field are also discussed. These recent developments are summarized and discussed to help encourage further contributions in this emerging and promisingf ield.[a] Q.

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Section: Introductionmentioning

confidence: 99%

Covalent Organic Frameworks (COFs) for Cancer Therapeutics

Guan

Zhou

et al. 2020

Chemistry A European J

153

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“…More importantly, as an emerging topology of silicon materials, 2D graphene‐like silicon nanosheets (GS NSs) differ strikingly from other silicon‐based materials such as porous silicon or silica and feature distinct physiochemical characters such as the quantum spin Hall effect, chiral superconductivity, and giant magnetoresistance owing to its special low‐buckled topography . Owing to their exceptional physical and chemical properties, 2D nanomaterials (2D NMs) have attracted extensive attention in biomedical applications such as cancer phototherapy, biosensors, and antimicrobial activity . Many 2D NMs such as graphene and derivatives, black phosphorus, MoS 2 , and Ti 3 C 2 T x MXenes exhibit antibacterial activity, which substantially reduces the possible development of bacterial drug resistance.…”

Section: Introductionmentioning

confidence: 99%

Anti‐Infective Application of Graphene‐Like Silicon Nanosheets via Membrane Destruction

Luo

Min

Han

et al. 2020

Adv Healthcare Materials

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The increasing problem of bacterial resistance to the currently effective antibiotics has resulted in the need for increasingly potent therapeutics to eradicate pathogenic microorganisms. 2D nanomaterials (2D NMs) have unique physical and chemical properties that make them attractive candidates for biomedical applications. Recently, the application of 2D NMs as antibacterial agents has attracted significant attention. Herein, a novel 2D graphene‐like silicon nanosheet (GS NS) antimicrobial agent is fabricated from pristine silicon crystals by ultrasonication, which results in a highly exfoliated planar morphology and a significantly larger surface area as compared with bulk silicon. The GS NSs exhibit remarkable in vitro broad‐spectrum bactericidal activity against Gram (−) Escherichia coli and Gram (+) Staphylococcus aureus because of a close interaction with the bacteria, which leads to highly efficient membrane destruction. The in vivo studies demonstrate that the local administration of GS NSs effectively mitigates implant‐related infection by reducing the bacterial burden of the extracted samples and accelerating the remission of local inflammation. Based on these encouraging results, GS NSs are expected to be a useful new member of the 2D NMs family, with the potential of effectively killing pathogenic bacteria in clinical applications.

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“…The 2D BP nanosheets have been demonstrated to exhibit unique physical and optoelectronic properties including the quantum Hall effect, saturable absorption and high performance of transistors and infrared PDs [55][56][57]. Subsequently, focus has been on the monolayer and fewlayer monoelemental 2D materials of group-VA elements (As, Sb, Bi, Te and Se), showing the promising candidates in future applications in electrics and optics [58].…”

Section: Elementary Materialsmentioning

confidence: 99%

Novel two-dimensional monoelemental and ternary materials: growth, physics and application

et al. 2020

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Abstract Two-dimensional (2D) materials have undergone a rapid development toward real applications since the discovery of graphene. At first, graphene is a star material because of the ultrahigh mobility and novel physics, but it always suffered from zero bandgap and limited device application. Then, 2D binary compounds such as transition-metal chalcogenides emerged as complementary materials for graphene due to their sizable bandgap and moderate electrical properties. Recently, research interests have turned to monoelemental and ternary 2D materials. Among them, monoelemental 2D materials such as arsenic (As), antimony (Sb), bismuth (Bi), tellurium (Te), etc., have been the focus. For example, bismuthene can act as a 2D topological insulator with nontrivial topological edge states and high bulk gap, providing the novel platforms to realize the quantum spin-Hall systems. Meanwhile, ternary 2D materials such as Bi2O2Se, BiOX and CrOX (X=Cl, Br, I) have also emerged as promising candidates in optoelectronics and spintronics due to their extraordinary mobility, favorable band structures and intrinsic ferromagnetism with high Curie temperature. In this review, we will discuss the recent works and future prospects on the emerging monoelemental and ternary materials in terms of their structure, growth, physics and device applications.

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Emerging two-dimensional monoelemental materials (Xenes) for biomedical applications

Abstract: This review summarizes the emerging two-dimensional (2D) monoelemental materials (Xenes) with unique 2D structures and their fascinating properties and showcases their potential in biomedical applications.

Cited by 536 publications

References 54 publications

Covalent Organic Frameworks (COFs) for Cancer Therapeutics

Covalent Organic Frameworks (COFs) for Cancer Therapeutics

Anti‐Infective Application of Graphene‐Like Silicon Nanosheets via Membrane Destruction

Novel two-dimensional monoelemental and ternary materials: growth, physics and application

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