Emerging views on the distinct but related roles of the main and accessory olfactory systems in responsiveness to chemosensory signals in mice

Restrepo, Diego; Arellano, Julie; Oliva, Anthony M.; Schaefer, Michele L.; Lin, Weihong

doi:10.1016/j.yhbeh.2004.02.009

Cited by 161 publications

(110 citation statements)

References 60 publications

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“…These olfactory systems have evolved so that they differ in their peripheral anatomy, their central projections and also in their function. However, both systems may also function synergistically in sustaining some pheromone-dependent behaviors [7,48,90]. Therefore, a central problem in olfaction is to elucidate the relative roles played by both systems in detecting olfactory information and in regulating chemosensory-dependent behaviors.…”

Section: Introductionmentioning

confidence: 99%

The main and the accessory olfactory systems interact in the control of mate recognition and sexual behavior

Keller

Baum

Brock

et al. 2009

Behavioural Brain Research

150

101

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Section: Introductionmentioning

confidence: 99%

The main and the accessory olfactory systems interact in the control of mate recognition and sexual behavior

Keller

Baum

Brock

et al. 2009

Behavioural Brain Research

150

101

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“…Anosmic mice show abnormal aggressive, afilliative and social behavior [2,28,31,33]. In mice, olfactory cues are detected by both the main olfactory system and the accessory olfactory system [9,51]. The accessory olfactory bulb processes non-volatile pheromones whereas the main olfactory bulb primarily processes volatile odorants and in mice is responsive to social cues present in urine [31,36,51,57].…”

Section: Introductionmentioning

confidence: 99%

Olfactory cues are sufficient to elicit social approach behaviors but not social transmission of food preference in C57BL/6J mice

Ryan

Young

Moy

et al. 2008

Behavioural Brain Research

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Mouse models for the study of autistic-like behaviors are increasingly needed to test hypotheses about the causes of autism, and to evaluate potential treatments. Both the automated 3-chambered social approach test and social transmission of food preference have been proposed as mouse behavioral assays with face validity to diagnostic symptoms of autism, including aberrant reciprocal social interactions and impaired communication. Both assays measure aspects of normal social behavior in the mouse. However, little is known regarding the salient cues present in each assay that elicit normal social approach and communication. To deconstruct the critical components, we focused on delivering discrete social and non-social olfactory and visual cues within the context of each assay. Results indicate that social olfactory cues were sufficient to elicit normal sociability in the 3-chambered social approach test On social transmission of food preference, isolated social olfactory cues were sufficient to induce social investigation, but not sufficient to induce food preference. These findings indicate that olfactory cues are important in mouse social interaction, but that additional sensory cues are necessary in certain situations. The present evidence that both the 3-chambered social approach assay and the social transmission of food preference assay require socially relevant cues to elicit normal behavior supports the use of these two assays to investigate autismrelated behavioral phenotypes in mice.

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“…T he olfactory system perceives not only odorants that convey information on the environment but also semiochemicals (chemicals involved in animal communication, from the Greek semeion for ''sign''), including pheromones (1)(2)(3)(4). A key step in transmission of information is activation of the canonical cAMP signaling pathway by binding of odorants to olfactory receptors, resulting in influx of Ca 2ϩ through a cyclic nucleotide-gated (CNG) channel and subsequent depolarization (5,6).…”

mentioning

confidence: 99%

“…Semiochemicals, such as pheromones, social attractants, and major histocompatibility complex (MHC)-related odorants, signal social and sexual status, genetic makeup, and species identity important for the survival of the individual and the species (1,(10)(11)(12)(13). Recent studies indicate that both the main olfactory epithelium (MOE) and olfactory bulbs respond to these chemosignals (14,15).…”

mentioning

confidence: 99%

Olfactory neurons expressing transient receptor potential channel M5 (TRPM5) are involved in sensing semiochemicals

Lin

Margolskee

Donnert

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

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Olfactory sensory neurons (OSNs) in the main olfactory epithelium respond to environmental odorants. Recent studies reveal that these OSNs also respond to semiochemicals such as pheromones and that main olfactory input modulates animal reproduction, but the transduction mechanism for these chemosignals is not fully understood. Previously, we determined that responses to putative pheromones in the main olfactory system were reduced but not eliminated in mice defective for the canonical cAMP transduction pathway, and we suggested, on the basis of pharmacology, an involvement of phospholipase C. In the present study, we find that a downstream signaling component of the phospholipase C pathway, the transient receptor potential channel M5 (TRPM5), is coexpressed with the cyclic nucleotide-gated channel subunit A2 in a subset of mature OSNs. These neurons project axons primarily to the ventral olfactory bulb, where information from urine and other socially relevant signals is processed. We find that these chemosignals activate a subset of glomeruli targeted by TRPM5-expressing OSNs. Our data indicate that TRPM5-expressing OSNs that project axons to glomeruli in the ventral area of the main olfactory bulb are involved in processing of information from semiochemicals.signal transduction ͉ pheromone ͉ stimulated emission depletion (STED) microscopy T he olfactory system perceives not only odorants that convey information on the environment but also semiochemicals (chemicals involved in animal communication, from the Greek semeion for ''sign''), including pheromones (1-4). A key step in transmission of information is activation of the canonical cAMP signaling pathway by binding of odorants to olfactory receptors, resulting in influx of Ca 2ϩ through a cyclic nucleotide-gated (CNG) channel and subsequent depolarization (5, 6). Targeted disruption of elements of the cAMP pathway, including the CNG channel subunit A2 (CNGA2) (7), the G protein G olf (8), or adenylyl cyclase (AC) III (9), result in severe deficit of odorantevoked responses to many odorants, demonstrating the dominant role of the cAMP pathway.Semiochemicals, such as pheromones, social attractants, and major histocompatibility complex (MHC)-related odorants, signal social and sexual status, genetic makeup, and species identity important for the survival of the individual and the species (1, 10-13). Recent studies indicate that both the main olfactory epithelium (MOE) and olfactory bulbs respond to these chemosignals (14, 15). Consistent with these findings, sensory information from the main olfactory bulb projects to areas in the hypothalamus housing neurons that produce gonadotropinreleasing hormone and plays an important role in reproduction (16,17). Further, a class of chemosensory receptors that recognize social amines found in urine have been identified recently in the MOE (18). Thus, it now is clear that the main olfactory system is involved in detection of semiochemicals and that the cAMP signaling pathway plays an important role in signal transduction f...

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Emerging views on the distinct but related roles of the main and accessory olfactory systems in responsiveness to chemosensory signals in mice

Cited by 161 publications

References 60 publications

The main and the accessory olfactory systems interact in the control of mate recognition and sexual behavior

The main and the accessory olfactory systems interact in the control of mate recognition and sexual behavior

Olfactory cues are sufficient to elicit social approach behaviors but not social transmission of food preference in C57BL/6J mice

Olfactory neurons expressing transient receptor potential channel M5 (TRPM5) are involved in sensing semiochemicals

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