EMMPRIN (CD147) expression and differentiation of papillary thyroid carcinoma: implications for immunocytochemistry in FNA cytology

Aratake, Yatsuki; Marutsuka, Kosuke; Kiyoyama, Kazuaki; Kuribayashi, Tadanobu; Miyamoto, T.; Yakushiji, Kazumichi; Ohno, Sachiyo; Miyake, Yasuyuki; Sakaguchi, Takuya; Kobayashi, Tadao K.; Okayama, Akira; Tamura, Kazuo; Ohno, Eiji

doi:10.1111/j.1365-2303.2009.00716.x

Cited by 11 publications

(12 citation statements)

References 28 publications

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“…Previous studies have shown that EMMPRIN/CD147, through multiple pathways and mechanisms, stimulates adjacent fibroblasts to produce matrix metalloproteinases, and thus promotes survival, invasion and metastasis of tumor cells (13,(18)(19)(20)(21)(22)(23)36). Indeed, EMMPRIN/CD147 expression is correlated significantly with the stage of clinicopathology in thyroid carcinoma (9), adenocarcinomas (7), esophageal squamous cell carcinomas (37) and prostate cancer (14). Furthermore, treatment with anti-EMMPRIN/CD147 antibody delays the formation of tumors in animal models (38).…”

Section: Discussionmentioning

confidence: 98%

“…Extracellular matrix metalloproteinase inducer (EMMPRIN, also known as CD147, EMMPRIN/CD147) is a highly glycosylated transmembrane protein and is abundantly expressed on the membrane surface of various tumor cells, including non-small cell lung cancer (NSCLC) (7), macrophage-like lymphoid neoplasm P388D1 cells (8), thyroid carcinoma (9), primary cutaneous malignant melanoma (10), intrahepatic cholangiocarcinoma (11), colorectal/gastric cancer (12), renal cell carcinoma (13), prostate cancer (14), cervical cancer (15), epithelial ovarian cancer (16) and breast carcinoma (17). EMMPRIN/CD147 promotes survival, invasion and metastasis of tumor cells through multiple pathways and mechanisms, including the functional loss of p53, a tumor suppressor (18), upregulated expression of vascular endothelial growth factor (VEGF) (13,(19)(20)(21), disruption of transforming growth factor-β1 (TGF-β1), a growth-modulating factor (22), and regulation of the urokinase-type plasminogen activation (uPA) system of serine proteases (23).…”

Section: Introductionmentioning

confidence: 99%

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Expression and clinical significance of extracellular matrix metalloproteinase inducer, EMMPRIN/CD147, in human osteosarcoma

Lü

Kim

et al. 2012

Oncology Letters

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Abstract. Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. Recent studies have shown that extracellular matrix metalloproteinase inducer (EMMPRIN/CD147) promotes adhesion, invasion and metastasis of malignant tumor cells. The aim of this study was to investigate the impact of EMMPRIN/CD147 expression on prognosis and its correlation with clinicopathological characteristics in patients with osteosarcoma. The expression of EMMPRIN/CD147 in 55 surgical specimens from patients with osteosarcoma at stage IIA or above, 15 non-tumor rib bone tissues, three human osteosarcoma cell lines (Saos-2, U-2OS and MG-63), the human osteoblast cell line HOB and the malignant melanoma cell line A375 were examined by immunohistochemistry, western blot analysis and ELISA, respectively. The potential association of the levels of EMMPRIN/CD147 expression in osteosarcoma specimens with the overall survival of patients was statistically analyzed. We found that the EMMPRIN/CD147 was expressed in 45 out of 55 osteosarcomas, with immunoreactivity primarily within the membrane and cytoplasm of tumor cells, but not in the non-tumor bone tissues. We also observed that EMMPRIN/CD147 was expressed in Saos-2, U-2OS, MG-63 and A375, but not in HOB cells. The levels of EMMPRIN/CD147 expression correlated positively with the pathological degree of osteosarcoma and negatively with the survival period of patients with osteosarcoma. The expression of EMMPRIN/CD147 is a potential factor in the development and prognosis of osteosarcoma and may be a novel therapeutic target of human osteosarcoma.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Expression and clinical significance of extracellular matrix metalloproteinase inducer, EMMPRIN/CD147, in human osteosarcoma

Lü

Kim

et al. 2012

Oncology Letters

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“…In addition, the sample sizes of these studies were small, and the methods were limited to IHC. Aratake et al [16,45] indicated that BSG expression correlates significantly with the degree of dedifferentiation of TC based on immunocytochemical analysis. More interestingly, they also observed MMP-2 positive expression in tumor cells and/or the adjacent tissue in all anaplastic carcinoma (ATC) cases, and the cytological atypia of cells with BSG positive expression was greater than in cells with negative BSG expression.…”

Section: Discussionmentioning

confidence: 99%

“…As for TC, BSG also plays an important role in the tumorigenicity, invasion, metastasis, and degree of dedifferentiation [16,17]. Recently, researchers have identi ed that BSG expression regulates tumor cell glycolysis, resulting in the progression of TC [17,18].…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Basigin Expression Level in Thyroid Cancer Tissues

Guo

Tang

Pang

et al. 2020

Preprint

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Background: Thyroid cancer (TC) is the most common endocrine malignancy, Basigin (also known as BSG) plays a crucial role in tumor cell invasion, metastasis, and angiogenesis. This study was designed to identify the change of BSG expression in TC and its possible potential mechanism. Methods: The BSG expression levels in TC were demonstrated using data collected from in-house immunohistochemical (IHC), RNA-sequencing (RNA-seq), microarrays and literatures. Integrated analysis was performed to determined BSG expression levels in TC comprehensively. The gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed with the integration of BSG co-expressed genes and differentially expressed genes (DEGs) in TC tissues to explore the potential mechanisms of BSG in TC. Results: The protein expression level of BSG was significantly higher in TC cases based on the IHC experiments. In addition, the combined SMD for BSG expression was 0.39 (p<0.0001), the diagnostic odds ratio was 3.69, and the AUC of the sROC curve was 0.6986 using 1182 TC cases and 437 non-cancerous cases from 17 independent datasets. Furthermore, BSG co-expressed genes tended to be enriched in gene terms of the extracellular matrix (ECM), cell adhesion, and cell-cell interactions. The expression levels of nine hub BSG co-expressed genes were markedly up-regulated in TC cases. Conclusion: BSG expression levels were closely correlated with the progression of TC and may affect the signals of the ECM, cell adhesion, and cell-cell interactions.

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“…As for TC, BSG also plays an important role in the tumorigenicity, invasion, metastasis, and degree of dedifferentiation [15,16]. Recently, researchers have identified that BSG expression regulates tumor cell glycolysis, resulting in the progression of TC [16,17].…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Basigin Expression Level in Thyroid Cancer Tissues

Guo

Tang

Pang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Thyroid cancer (TC) is the most common endocrine malignancy, Basigin (also known as BSG) plays a crucial role in tumor cell invasion, metastasis, and angiogenesis. This study was designed to identify the change of BSG expression in TC and its possible potential mechanism. Methods The BSG expression levels in TC were demonstrated using data collected from in-house immunohistochemical (IHC), RNA-sequencing (RNA-seq), microarrays and literatures. Integrated analysis was performed to determined BSG expression levels in TC comprehensively. The gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed with the integration of BSG co-expressed genes and differentially expressed genes (DEGs) in TC tissues to explore the potential mechanisms of BSG in TC. Results The protein expression level of BSG was significantly higher in TC cases based on the IHC experiments. In addition, the combined SMD for BSG expression was 0.39 (p < 0.0001), the diagnostic odds ratio was 3.69, and the AUC of the sROC curve was 0.6986 using 1182 TC cases and 437 non-cancerous cases from 17 independent datasets. Furthermore, BSG co-expressed genes tended to be enriched in gene terms of the extracellular matrix (ECM), cell adhesion, and cell-cell interactions. The expression levels of nine hub BSG co-expressed genes were markedly up-regulated in TC cases. Conclusion BSG expression levels were closely correlated with the progression of TC and may affect the signals of the ECM, cell adhesion, and cell-cell interactions.

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EMMPRIN (CD147) expression and differentiation of papillary thyroid carcinoma: implications for immunocytochemistry in FNA cytology

Cited by 11 publications

References 28 publications

Expression and clinical significance of extracellular matrix metalloproteinase inducer, EMMPRIN/CD147, in human osteosarcoma

Expression and clinical significance of extracellular matrix metalloproteinase inducer, EMMPRIN/CD147, in human osteosarcoma

Immunohistochemical Basigin Expression Level in Thyroid Cancer Tissues

Immunohistochemical Basigin Expression Level in Thyroid Cancer Tissues

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