Emodin alleviates aortic valvular calcification by inhibiting the AKT/FOXO1 pathway

Luo, Man; Sun, Wei; Zhou, Bin; Kong, Xiangqing

doi:10.1016/j.aanat.2021.151885

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…p-AKT and p-FOXO1 were upregulated in porcine aortic valve interstitial cells under hypercalcemic conditions, and this upregulation could be reversed through emodin treatment. The inhibitory effect of emodin was reversed by the addition of AKT activator, suggesting that emodin alleviated hypercalcemia-associated valve calcification by inhibiting AKT/FOXO1 signaling (Luo et al, 2022). These findings provide new insights into the treatment strategies for clinical valve calcification.…”

Section: Valvular Heart Diseasementioning

confidence: 76%

Emodin in cardiovascular disease: The role and therapeutic potential

Guo

Zhang

2022

Front. Pharmacol.

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Emodin is a natural anthraquinone derivative extracted from Chinese herbs, such as Rheum palmatum L, Polygonum cuspidatum, and Polygonum multiflorum. It is now also a commonly used clinical drug and is listed in the Chinese Pharmacopoeia. Emodin has a wide range of pharmacological properties, including anticancer, antiinflammatory, antioxidant, and antibacterial effects. Many in vivo and in vitro experiments have demonstrated that emodin has potent anticardiovascular activity. Emodin exerts different mechanisms of action in different types of cardiovascular diseases, including its involvement in pathological processes, such as inflammatory response, apoptosis, cardiac hypertrophy, myocardial fibrosis, oxidative damage, and smooth muscle cell proliferation. Therefore, emodin can be used as a therapeutic drug against cardiovascular disease and has broad application prospects. This paper summarized the main pharmacological effects and related mechanisms of emodin in cardiovascular diseases in recent years and discussed the limitations of emodin in terms of extraction preparation, toxicity, and bioavailability-related pharmacokinetics in clinical applications.

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Section: Valvular Heart Diseasementioning

confidence: 76%

Emodin in cardiovascular disease: The role and therapeutic potential

Guo

Zhang

2022

Front. Pharmacol.

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“…To investigate the role of emodin in vascular calcification, researchers induced aortic valvular calcification in mice with vitamin D and treated them with emodin. Emodin inhibited calcium levels in serum and valves and reduced calcium accumulation in the aortic valvular by inhibiting the AKT/FOXO1 signaling pathway ( Luo et al, 2022 ). Evidence suggested that emodin-induced oxidative inhibition of mitochondrial function contributes to ER-associated apoptosis mediated by BiP/IRE1α/CHOP signaling pathway ( Qiu et al, 2021 ).…”

Section: Prevention and Treatment For Cardiovascular Calcificationmentioning

confidence: 99%

Reactive Oxygen Species in Cardiovascular Calcification: Role of Medicinal Plants

Qiao

2022

Front. Pharmacol.

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Cardiovascular calcification, including vascular calcification and calcific aortic valve disease (CAVD), is a serious worldwide health problem, especially in older adults. The mechanisms underlying cardiovascular calcifications are complex and multifactorial. An increase in reactive oxygen species (ROS) and oxidative stress play important roles in the initiation and development of cardiovascular calcification. This mini-review summarizes the recent evidence that supports the association of ROS with vascular calcification and CAVD and discusses the role of medicinal plants for the prevention and treatment of cardiovascular calcification.

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