Emodin, an anthraquinone derivative from Rheum officinale Baill, enhances cutaneous wound healing in rats

Tang, Tian; Yin, Longwu; Yang, Jing; Shan, Guang

doi:10.1016/j.ejphar.2007.02.033

Cited by 108 publications

(67 citation statements)

References 44 publications

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“…Emodin from Rheum officinale Baill showed encouraging results of repair of excision wounds in rats (413). Embelin from extracts of leaves of Embelia ribes Burm was effective in healing wound in excision, incision and dead space model on Swiss Albino rats (213).…”

Section: Active Plant Parts Studied For Wound Healingmentioning

confidence: 99%

Phyto-Extracts in Wound Healing

2013

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-Data generated through systematic investigation, carried out on the evaluation of phyto-extracts on wound healing research during the last 20 years have been compiled. About 450 plant species having wound healing properties have been identified. The present knowledge of the wound healing process comprise coagulation, inflammation, proliferation, formation and accumulation of fibrous tissues, collagen deposition, epithelialization, contraction of wound with formation of granulation tissues, remodeling and maturation. The constituents of the plant extracts modulate one or more of the above stages. It was the endeavor to identify the active constituents responsible for antimicrobial activity, free radical scavenging properties, stimulators of enhanced collagen production and/or angiogenesis promoters with identification of lead scaffold chemical structures. Multiple phytochemicals concentrated and blended in optimal concentrations, are expected to be available in future years to carry out multi-tasking efforts in wound healing as more knowledge about the properties of the key constituents are unveiled.

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Section: Active Plant Parts Studied For Wound Healingmentioning

confidence: 99%

Phyto-Extracts in Wound Healing

2013

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“…The concentrations of emodin (0.1, 0.3, 1, 3, 10 mM) were selected based on our preliminary experiments and the effectual dose applied in previous studies (Kaneshiro et al, 2006;Tang et al, 2007). The specific antagonist of P2X 7 R BBG was set as positive control, and the doses that ranged from 0.1 to 10 mM were also chosen according to previous work (Jiang et al, 2000;Liu et al, 2010).…”

Section: Animals and Reagentsmentioning

confidence: 99%

“…Emodin (1,3,8-trihydroxy-6-methyl-anthraquinone) is one of the most effective constituents in the traditional Chinese herb Rheum officinale Baill (Tang et al, 2007), derived from the root and rhizome of Rheum palmatum L. (Tsai & Chen, 1992). It exerts effects on a number of biological activities including anti-inflammation, antivirus, antitumor and immunosuppression (Huang et al, 1991(Huang et al, , 1992Kaneshiro et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Emodin inhibits ATP-induced IL-1β secretion, ROS production and phagocytosis attenuation in rat peritoneal macrophages via antagonizing P2X₇receptor

Zhu¹,

Wang²,

Wang

et al. 2013

Pharmaceutical Biology

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Emodin inhibits ATP-induced IL-1β secretion, ROS production and phagocytosis attenuation in rat peritoneal macrophages via antagonizing P2X 7 receptor, Pharmaceutical Biology, 52:1, 51-57, DOI: 10.3109/13880209.2013 ] c increase evoked by ATP (5 mM) was inhibited by emodin, in a dose-dependent manner with IC 50 of 0.5 mM. Furthermore, emodin reduced the IL-1b release induced by ATP (2 mM) in lipopolysaccharide (LPS)-activated macrophages, with an IC 50 of 1.6 mM. Emodin also strongly suppressed the ROS production and phagocytosis attenuation triggered by ATP (1 mM), with IC 50 values of 1 mM and 0.7 mM, respectively. Besides, BBG, a specific antagonist of P2X 7 R, exhibited similar suppressive effects on these inflammation responses. Conclusion: These results showed the inhibitory effects of emodin on ATP-induced [Ca 2+ ] c increase, IL-1b release, ROS production and phagocytosis attenuation in rat peritoneal macrophages, by inhibiting the activation of P2X 7 R.

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“…During the proliferative phase of wound healing, wound contraction enhances closure of the defect by pulling the edges of the wound towards the center (Tang et al, 2007). Contraction facilitates reepithelization by migrating keratinocytes in the epidermis layers (Strodtbeck, 2001).…”

Section: Discussionmentioning

confidence: 99%

Labisia pumila improves wound healing process in ovariectomized rat model

Ahmad

Shuid

Mohamed

2018

Bangladesh J Pharmacol

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Labisia pumila (Blume) Fern.-Vill. synonym Marantodes pumilum (Blume) Kuntze is a flowering plant of the Primulaceae family. It is used traditionally by the Malay women to shrink the uterus, facilitate labor, improve menstrual irregularities and as post-partum medicine (Runi, 2000). The ethnopharmacological studies and clinical findings have illustrated that L. pumila possesses many biological functions, including phytoestrogenic, antimicrobial, anti-oxidative, anti-inflammatory properties and anti-aging (Choi et al., 2010;Nadia et al., 2012). Recent studies on L. pumila also demonstrated that it could also be used for osteoporosis, cardiovascular diseases, and metabolic disorders (Shuid et al., 2011). The ethnobotanical and therapeutic properties of L. pumila make it a potential source of novel medicine for the healing of wounds. Therefore, this study investigates the effectiveness of topical application of the aqueous extract of L. pumila on the rate of wound closure and the histology of the wound area. Materials and Methods Plant collection and extractionThe plant species were collected from their natural habitat in the rainforest of Taiping, Perak, Malaysia in October, 2014. Identification of the plant species was verified by a botanist from the Faculty of Science, Universiti Kebangsaan Malaysia (UKM). All voucher specimens were deposited in the Herbarium of UKM (voucher specimen number of L. pumila var. alata = UKMB 30006/SM 2622 and var. pumila = UKMB 30007/ SM s.n.). The standardized aqueous extraction method was used according to Jamal et al. (2003) AbstractThe purpose of this study was to determine the wound healing effect of Labisia pumila in the ovariectomized rat model. Ninety-nine Sprague Dawley female rats equally divided into nine groups; where five were control groups, and four were treated groups. The dressing was changed daily, starting from the wound induction until complete healing. The percentage of wound contraction was measured on day 0, 2, 5, 8, 9, 10, 11, 12 and 13. Three rats were sacrificed from each group on day 2, 5 and 8 respectively for evaluating of histological assessments. Wounds dressed with extract showed considerable healing and significantly healed faster compared to all control groups (p<0.05). Moreover, histological analysis revealed remarkable reduction in the scar width correlated with the enhanced collagen content and fibroblast cells, accompanied by a reduction of inflammatory cells in the granulation tissues.In conclusion, L. pumila may promote wound healing in postmenopausal rat model. Article Info

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Emodin, an anthraquinone derivative from Rheum officinale Baill, enhances cutaneous wound healing in rats

Cited by 108 publications

References 44 publications

Phyto-Extracts in Wound Healing

Phyto-Extracts in Wound Healing

Emodin inhibits ATP-induced IL-1β secretion, ROS production and phagocytosis attenuation in rat peritoneal macrophages via antagonizing P2X₇receptor

Labisia pumila improves wound healing process in ovariectomized rat model

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Emodin, an anthraquinone derivative from Rheum officinale Baill, enhances cutaneous wound healing in rats

Cited by 108 publications

References 44 publications

Phyto-Extracts in Wound Healing

Phyto-Extracts in Wound Healing

Emodin inhibits ATP-induced IL-1β secretion, ROS production and phagocytosis attenuation in rat peritoneal macrophages via antagonizing P2X7receptor

Labisia pumila improves wound healing process in ovariectomized rat model

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Emodin inhibits ATP-induced IL-1β secretion, ROS production and phagocytosis attenuation in rat peritoneal macrophages via antagonizing P2X₇receptor