Emodin opposes chronic unpredictable mild stress induced depressive-like behavior in mice by upregulating the levels of hippocampal glucocorticoid receptor and brain-derived neurotrophic factor

Meng, Long; Fu, Qiang; Li, Ying; Li, Shanshan; Xue, Jinsong; Ma, Shengming

doi:10.1016/j.fitote.2014.06.007

Cited by 69 publications

(54 citation statements)

References 51 publications

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“…In chronic unpredictable mild stress mice, emodin treatment (20, 40 and 80 mg/kg) reversed the behavioural deficiency. Emodin normalized the change of the plasma corticosterone level and up‐regulated the hippocampal glucocorticoid receptor (GR) (mRNA and protein) and brain‐derived neurotrophic factor (BDNF) (mRNA) expression levels (Li et al ., ). It was shown for the first time that emodin treatment led to induced neurite outgrowth through the PI3K/Akt/GSK‐3β signalling pathway in Neuro2a cells (Park et al ., ).…”

Section: Pharmacologymentioning

confidence: 97%

Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics

Dong

Yin

et al. 2016

Phytotherapy Research

568

365

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Emodin is a natural anthraquinone derivative that occurs in many widely used Chinese medicinal herbs, such as Rheum palmatum, Polygonum cuspidatum and Polygonum multiflorum. Emodin has been used as a traditional Chinese medicine for over 2000 years and is still present in various herbal preparations. Emerging evidence indicates that emodin possesses a wide spectrum of pharmacological properties, including anticancer, hepatoprotective, antiinflammatory, antioxidant and antimicrobial activities. However, emodin could also lead to hepatotoxicity, kidney toxicity and reproductive toxicity, particularly in high doses and with long-term use. Pharmacokinetic studies have demonstrated that emodin has poor oral bioavailability in rats because of its extensive glucuronidation. This review aims to comprehensively summarize the pharmacology, toxicity and pharmacokinetics of emodin reported to date with an emphasis on its biological properties and mechanisms of action. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Pharmacologymentioning

confidence: 97%

Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics

Dong

Yin

et al. 2016

Phytotherapy Research

568

365

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“…The TST was performed based on a previously described method (20). In brief, the mouse was suspended 25 cm above the floor by the tip of the tail (1 cm) tied up to the level.…”

Section: Animalsmentioning

confidence: 99%

Anti-depressant-like effect of atractylenolide I in a mouse model of depression induced by chronic unpredictable mild stress

Gao

Zhu

et al. 2017

Exp Ther Med

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Abstract. Atractylenolide I (AT-I), a major component of the rhizoma of Atractylodes macrocephala Koidz., exerts a wide range of activities. The purpose of the present study was to investigate the anti-depressant-like effect of AT-I in a mouse model of chronic unpredictable mild stress (CUMS), and to explore the possible molecular mechanism involved. It was revealed that AT-I significantly ameliorated CUMS-induced depressive-like behaviors, as evidenced by increased sucrose preference as well as shortened immobility time in the forced swimming and the tail suspension test. In addition, AT-I reduced CUMS-induced decreases in the concentrations of serotonin and norepinephrine in the hippocampus. Furthermore, AT-I inhibited the activation of the nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome as well as the concentration of the pro-inflammatory cytokine interleukin (IL)-1β in the hippocampi of mice subjected to CUMS. In conclusion, the results of the present study suggested that AT-I exerts anti-depressant-like effects in a CUMS-induced model of depression in mice, the molecular mechanism of which is associated with the inhibition of NLRP3 inflammasome activation to decrease IL-1β production.

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“…Control group were undisturbed except for necessary housekeeping procedures. The frequency of stressors was conducted as previously described (14). By reference to the literature (15), we chose two doses of Umb (20, 40 mg/ kg), as supported by the preliminary experiment.…”

Section: Experimental Protocolmentioning

confidence: 99%