Empathy, schizotypy, and visuospatial transformations

Thakkar, Katharine N.; Park, Sohee

doi:10.1080/13546801003711350

Cited by 58 publications

(86 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Faster allocentric mental rotation was associated with increased schizotypy 87 and more specifically, negative schizotypy in women. 88 Findings are mixed with respect to self-other transformation involving egocentric mental rotation. Both impaired, 89 and enhanced 87,88,90 egocentric mental rotation performance have been reported in relation to elevated schizotypy.…”

Section: Imagery and Representationmentioning

confidence: 99%

“…88 Findings are mixed with respect to self-other transformation involving egocentric mental rotation. Both impaired, 89 and enhanced 87,88,90 egocentric mental rotation performance have been reported in relation to elevated schizotypy. These findings have implications for social cognitive abilities (see Cohen et al 15 ), notably theory-of-mind because one crucial aspect of mentalizing involves visuospatial perspective taking and simulation.…”

Section: Imagery and Representationmentioning

confidence: 99%

“…These findings have implications for social cognitive abilities (see Cohen et al 15 ), notably theory-of-mind because one crucial aspect of mentalizing involves visuospatial perspective taking and simulation. 91 Although enhanced egocentric perspective-taking ability may be associated with increased empathy, 88 in particular in women 91 and as a function of life experience, 93 excessive perspective-taking could lead to reduced agency and dissociative experiences.…”

Section: Imagery and Representationmentioning

confidence: 99%

See 2 more Smart Citations

Cognition and Brain Function in Schizotypy: A Selective Review

Ettinger

Möhr

Gooding

et al. 2015

Schizophrenia Bulletin

214

184

View full text Add to dashboard Cite

Schizotypy refers to a set of personality traits thought to reflect the subclinical expression of the signs and symptoms of schizophrenia. Here, we review the cognitive and brain functional profile associated with high questionnaire scores in schizotypy. We discuss empirical evidence from the domains of perception, attention, memory, imagery and representation, language, and motor control. Perceptual deficits occur early and across various modalities. While the neural mechanisms underlying visual impairments may be linked to magnocellular dysfunction, further effects may be seen downstream in higher cognitive functions. Cognitive deficits are observed in inhibitory control, selective and sustained attention, incidental learning, and memory. In concordance with the cognitive nature of many of the aberrations of schizotypy, higher levels of schizotypy are associated with enhanced vividness and better performance on tasks of mental rotation. Language deficits seem most pronounced in higher-level processes. Finally, higher levels of schizotypy are associated with reduced performance on oculomotor tasks, resembling the impairments seen in schizophrenia. Some of these deficits are accompanied by reduced brain activation, akin to the pattern of hypoactivations in schizophrenia spectrum individuals. We conclude that schizotypy is a construct with apparent phenomenological overlap with schizophrenia and stable interindividual differences that covary with performance on a wide range of perceptual, cognitive, and motor tasks known to be impaired in schizophrenia. The importance of these findings lies not only in providing a fine-grained neurocognitive characterization of a personality constellation known to be associated with real-life impairments, but also in generating hypotheses concerning the aetiology of schizophrenia.

show abstract

Section: Imagery and Representationmentioning

confidence: 99%

Section: Imagery and Representationmentioning

confidence: 99%

Section: Imagery and Representationmentioning

confidence: 99%

See 1 more Smart Citation

Cognition and Brain Function in Schizotypy: A Selective Review

Ettinger

Möhr

Gooding

et al. 2015

Schizophrenia Bulletin

214

184

View full text Add to dashboard Cite

show abstract

“…The computerized version of the spatial cognition task was designed as per previous description (Thakkar and Park, 2010). The task focused on the ability of the subjects to take perspective from an egocentric or allocentric point of view and to rotate mentally the stimulus or their point of view.…”

Section: Spatial Cognition Taskmentioning

confidence: 99%

“…Among several domains of cognitive functions that have been examined in this disorder, spatial cognition is an area of active inquiry (Bose et al, 2014); interestingly, visuospatial abilities have been found to have intriguing interactions with several measures that are related to schizophrenia pathogenesis like empathy (Decety and Lamm, 2007), schizotypy (Thakkar and Park, 2010), and theory of mind (Bosia et al, 2012;Iacoboni and Dapretto, 2006). Models of visuospatial abilities posit two perspectives of visual space: allocentric (object-or environmentcentered) reference and egocentric (self-centered or body-centered) reference (O'Keefe and Nadel, 1978).…”

Section: Introductionmentioning

confidence: 99%

Cognitive mapping deficits in schizophrenia: Evidence from clinical correlates of visuospatial transformations

Agarwal

Danivas

Amaresha

et al. 2015

Psychiatry Research

View full text Add to dashboard Cite

Classification of social anhedonia using temporal and spatial network features from a social cognition fMRI task

Krohne

Wang

Hinrich

et al. 2019

Human Brain Mapping

View full text Add to dashboard Cite

Previous studies have suggested that the degree of social anhedonia reflects the vulnerability for developing schizophrenia. However, only few studies have investigated how functional network changes are related to social anhedonia. The aim of this fMRI study was to classify subjects according to their degree of social anhedonia using supervised machine learning. More specifically, we extracted both spatial and temporal network features during a social cognition task from 70 subjects, and used support vector machines for classification. Since impairment in social cognition is well established in schizophrenia‐spectrum disorders, the subjects performed a comic strip task designed to specifically probe theory of mind (ToM) and empathy processing. Features representing both temporal (time series) and network dynamics were extracted using task activation maps, seed region analysis, independent component analysis (ICA), and a newly developed multi‐subject archetypal analysis (MSAA), which here aimed to further bridge aspects of both seed region analysis and decomposition by incorporating a spotlight approach.We found significant classification of subjects with elevated levels of social anhedonia when using the times series extracted using MSAA, indicating that temporal dynamics carry important information for classification of social anhedonia. Interestingly, we found that the same time series yielded the highest classification performance in a task classification of the ToM condition. Finally, the spatial network corresponding to that time series included both prefrontal and temporal‐parietal regions as well as insula activity, which previously have been related schizotypy and the development of schizophrenia.

show abstract

Empathy, schizotypy, and visuospatial transformations

Cited by 58 publications

References 81 publications

Cognition and Brain Function in Schizotypy: A Selective Review

Cognition and Brain Function in Schizotypy: A Selective Review

Cognitive mapping deficits in schizophrenia: Evidence from clinical correlates of visuospatial transformations

Classification of social anhedonia using temporal and spatial network features from a social cognition fMRI task

Contact Info

Product

Resources

About