Emphysema and DL CO predict a clinically important difference for 6MWD decline in COPD

Díaz, Alejandro A.; Pinto-Plata, Víctor; García-Hernández, Cristina; Peña, Javier; Ramos, Cristóbal; Díaz, Juan Carlos; Klaassen, Julieta; Patino, Cecilia María; Saldías, Fernando; Díaz, Orlando

doi:10.1016/j.rmed.2015.04.009

Cited by 45 publications

(45 citation statements)

References 42 publications

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“…By contrast, quantifying the severity of emphysema by DL CO is a more feasible method that can be performed simply at out-patient clinics with no harm to patients. As expected, previous data have shown that DL CO corresponded well with the CT emphysema score and predicted the risk of acute exacerbation, as well as the patients' exercise capacity (16,31). Our results also demonstrated that lower DL CO value was associated with acute exacerbation in univariate analysis ( Table 3).…”

Section: Discussionsupporting

confidence: 89%

Lower diffusing capacity with chronic bronchitis predicts higher risk of acute exacerbation in chronic obstructive lung disease

Lee¹,

Kim²,

Lee³

et al. 2016

J. Thorac. Dis.

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Background: This study was designed to evaluate the effect of chronic bronchitis (CB) symptoms and degree of emphysema in a multicenter Korean cohort. Methods: From April 2012 to May 2015, patients diagnosed with chronic obstructive lung disease (COPD) who were aged above 40 years at 46 hospitals throughout Korea were enrolled. All of the patients were classified according to CB symptoms and the diffusing capacity of the lung for carbon monoxide (DL CO ); demographic data, symptom scores, and the result of lung function tests and exacerbations were then analyzed. Results: A total of 812 patients were enrolled. Among these patients, 285 (35.1%) had CB symptoms.

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Section: Discussionsupporting

confidence: 89%

Lower diffusing capacity with chronic bronchitis predicts higher risk of acute exacerbation in chronic obstructive lung disease

Lee¹,

Kim²,

Lee³

et al. 2016

J. Thorac. Dis.

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“…In patients with COPD, MRI and CT can show changes in the muscle mass of lower limbs after a period of exercise 7 , 16 . Likewise, CT shows a high correlation between muscle thickness and the distance walked during the 6MWT 5 , 6 . Although CT is useful for evaluating the progression of muscular dysfunction in patients with COPD, 5 routine clinical use is limited because of economic costs.…”

mentioning

confidence: 99%

Sonographic Measurement of the Quadriceps Muscle in Patients With Chronic Obstructive Pulmonary Disease

Cruz‐Montecinos

Guajardo-Rojas

Montt

et al. 2016

J of Ultrasound Medicine

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“…Besides airway obstruction, the changes of lung parenchymal structure, resulting in lung hyperinflation (air trapping) and gas exchange abnormalities, are also the key pathophysiologic processes during COPD progression. The corresponding functional studies suggest that lung volumetric parameters such as residual volume (RV) and total lung capacity (TLC) are important measurements in evaluating COPD severities and treatment responses67. However, a gold standard method to evaluate lung volumes has not yet been confirmed.…”

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confidence: 99%

The measurement of lung volumes using body plethysmography and helium dilution methods in COPD patients: a correlation and diagnosis analysis

Tang

Zhang

Feng

et al. 2016

Sci Rep

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Chronic obstructive pulmonary disease (COPD) is a chronic airway disease characterized by persistent airflow limitation. Moreover, lung hyperinflation evaluated by lung volumes is also the key pathophysiologic process during COPD progression. Nevertheless, there is still no preferred method to evaluate lung volumes. For this study, we recruited 170 patients with stable COPD to assess lung volumes stratified by airflow limitation severity. Lung volumes including residual volume (RV) and total lung capacity (TLC) were determined by both body plethysmography and helium dilution methods. The discrepancies between these two methods were recorded as ΔRV%pred, ΔTLC%pred, and ΔRV/TLC. We found that ΔRV%pred, ΔTLC%pred, and ΔRV/TLC increased significantly with the severity of COPD. The differences of lung capacity between these two methods were negatively correlated with FEV1%pred, and diffusing capacity for carbon monoxide (DLCO%pred). Moreover, the receiver operating characteristic (ROC) for ΔTLC%pred to distinguish severe COPD from non-severe COPD had an area under curve (AUC) of 0.886. The differences of lung volume parameters measured by body plethysmography and helium dilution methods were associated with airflow limitation and can effectively differentiate COPD severity, which may be a supportive method to assess the lung function of stable COPD patients.

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Emphysema and DL CO predict a clinically important difference for 6MWD decline in COPD

Abstract: In COPD patients the burden of emphysema on CT scan and DLCO predict a clinically meaningful decline in exercise capacity.

Cited by 45 publications

References 42 publications

Lower diffusing capacity with chronic bronchitis predicts higher risk of acute exacerbation in chronic obstructive lung disease

Lower diffusing capacity with chronic bronchitis predicts higher risk of acute exacerbation in chronic obstructive lung disease

Sonographic Measurement of the Quadriceps Muscle in Patients With Chronic Obstructive Pulmonary Disease

The measurement of lung volumes using body plethysmography and helium dilution methods in COPD patients: a correlation and diagnosis analysis

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