2021
DOI: 10.1097/ta.0000000000003375
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Emulating an RCT in observational research in chest trauma: The target trial approach

Abstract: BACKGROUND: While the concept of a "target trial"-optimizing the quality of observational studies by attempting to emulate the ideal world conditions of a randomized controlled trial-was first expounded over a decade ago, the take up of this concept in the design and analysis of trials in trauma is lacking. The target trial approach avoids common errors in observational research to increase its scientific validity as well as potentially enable causal questions to be answered without the expense and intricacies… Show more

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