Emulgel: A Boon for Enhanced Topical Drug Delivery

Charyulu, Narayana; Joshi, Punam; Dubey, Akhilesh; Shetty, Amitha

doi:10.5530/jyp.2021.13.17

Cited by 16 publications

(16 citation statements)

References 4 publications

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“…The drug candidate suitable to formulate as an emulgel should possess' high pKa value, Half-life (t 1/2 ) of less than 10 h, less molecular size, the molecular mass of 500 daltons or less, partition coefficient (logP) value of 0.8 to 5 and less polarity. In addition, the drug candidate should be non-irritating with a skin permeability coefficient of equal to or more than 0.5×10 -3 cm/h [3] .…”

Section: Drugmentioning

confidence: 99%

“…The vehicle used for the preparation of emulgel should possess properties like efficient deposition of the medication with even distribution on the skin; deliver and release the drug at the site of operation; sustaining a level of therapeutics in the target tissue for a sufficient period. Furthermore, it should be compatible with the skin of the patient [3] .…”

Section: Vehiclementioning

confidence: 99%

“…The topical formulations offer an array of benefits such as prevention of pre-systemic metabolism, augmented bioavailability and therapeutic response, improved patient compliance, ease of administration, reduced gastrointestinal tract incompatibility [2] . Moreover, topical formulations are highly appropriate for the delivery of cargo with a narrow therapeutic window [3] .…”

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confidence: 99%

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Topical Emulgel: Basic Considerations in Development and Advanced Research

Malavi¹,

Kumbhar²,

Manjappa³

et al. 2022

IJPS

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Malavi et al.: Emulgel Basic Consideration and Advanced ResearchEmulgel is a promising drug delivery strategy that has gained popularity in recent years for topical delivery of hydrophobic drugs. Emulgel is an emulsion that is gelled by mixing it with gelling agents. It is an interesting topical drug delivery system as it has a dual release control system, i.e., gel and emulsion. Emulgel has several favorable properties for dermatological use such as being thixotropic, greaseless, easily spreadable, easily removable, emollient, nonstaining, long shelf life, transparent and pleasing appearance. Despite, many advantages of the emulgel, the disadvantages include low permeability, poor pharmacokinetics and pharmacodynamics performance; therefore an advanced concept nanoemulgel came into the existence. Regardless of having few limitations, nanoemulgel formulation can be considered as impending and promising candidates for topical delivery of lipophilic drugs in the future. To know the potential of emulgel as a delivery vehicle, the present review offers a comprehensive overview on the rationale behind the use of emulgel, formulation considerations and characterization of emulgel and advanced research in the emulgel. Furthermore, we have summarized and discussed the outcome of different in vitro and in vivo studies of emulgel or nanoemulgel. Finally, the major challenges of nanoemulgel drug delivery system, patented and marketed emulgel or nanoemulgel formulations have been discussed. Based on the studies covered in this manuscript, it was understood that emulgel or nanoemulgel has emerged as an optimistic approach in the topical delivery of hydrophobic drugs to improve solubility, permeability and bioavailability, and reduce toxicities.

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Section: Drugmentioning

confidence: 99%

Section: Vehiclementioning

confidence: 99%

mentioning

confidence: 99%

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Topical Emulgel: Basic Considerations in Development and Advanced Research

Malavi¹,

Kumbhar²,

Manjappa³

et al. 2022

IJPS

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“…Some smaller blood vessels are also present in this layer, which provides nourishment, elasticity and oxygen to the epidermis. (18,19)…”

Section: Dermismentioning

confidence: 99%

Emulgel

Ahmed

Verma

Khan

et al. 2022

ijhs

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Topical delivery of drugs is one of the ideal routes of administrating a wide range of drug candidates and emulgels are emerging as a novel formulation, which exhibited the characteristics of both the emulsions and gels. Emulgel demonstrated improved penetrability during several studies and it is able to deliver hydrophilic as well as hydrophobic drugs and hence overcome the limitations of traditionally available topical preparations. More stable and effective emulgels can be prepared by nanonizing and micronizing the globules of emulsions, which improves the stability and half-life of Emulgels. The commercial availability along with the presence of strong clinical pipeline of emulgels is indicating towards the acceptance of this formulation while several advantages associated with this approach is also suggesting towards its potential as ideal topical drug delivery system. This article enlisted in-depth information about the emulgels, its components and structure along with the general method of production, evaluation and future scenario of this approach. The article also involved information about the patents insight, commercially available products and previously used drugs for developing stable emulgels.

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“…Emulgels have the ability to deliver hydrophilic and lipophilic drugs. These semi-solid systems not only have the advantages of emulsions and gels but are also stable [ 7 , 8 ]. O/W emulgels or O/W emulsion hydrogels can deliver lipid-soluble compounds and have good physical stability and mechanical properties as gels [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Physical, Mechanical, Biopharmaceutical Properties of Emulgels and Bigel Containing Ciclopirox Olamine

et al. 2022

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Emulsions are thermodynamically unstable systems and it is difficult to produce biphasic formulations with large amounts of oil. The aim of our study was to prepare biphasic formulations containing 1% ciclopirox olamine and to determine the influence of the method of oil incorporation (without and with emulsifier and gelifier) on the physical (pH, particle size, rheological properties), mechanical, and biopharmaceutical properties of the formulations. It was found that the use of a poloxamer 407 gel as the hydrophase could result in a stable formulation when an oil with (EPG) or without an emulsifier (APG) or oleogel (OPG) was used as the oily phase. The results of the studies showed that the addition of an emulsifier (polysorbate 80) led to a decrease in the sol-gel temperature, a slower release of ciclopirox olamine, and a higher stability in the freeze–thaw test. However, regardless of the way the oil is incorporated, the particles are distributed in the same range and the antifungal activity against T. rubrum is the same. It is possible to create a biphasic formulation with a large amount of oil and poloxamer gel, but for greater stability, it is recommended to include an emulsifier in the composition.

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Emulgel: A Boon for Enhanced Topical Drug Delivery

Cited by 16 publications

References 4 publications

Topical Emulgel: Basic Considerations in Development and Advanced Research

Topical Emulgel: Basic Considerations in Development and Advanced Research

Emulgel

Assessment of Physical, Mechanical, Biopharmaceutical Properties of Emulgels and Bigel Containing Ciclopirox Olamine

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