Emulgel: An Emerging Approach towards Effective Topical Drug Delivery

Kaushik, Dhirender; Pandey, Parijat; Minocha, Neha; Vashist, Neelam; Shah, R. K.; Saini, Sapna; Makhija, Manish; Purohit, Deepika

doi:10.2174/2210303112666220818115231

Cited by 5 publications

(1 citation statement)

References 66 publications

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“…NEs can be transformed into a gel to form a nanoemulgel by dispersing the oily phase (along with the drug) within an aqueous phase of the gel base. Emulgels have improved stability with a prolonged contact time [103]. Nanoemulgel was formulated with undecylenic acid as the oily phase and laden with amorolfine HCl incorporating thioglycolic acid as a permeation enhancer [44].…”

Section: Metallic Nanoparticlesmentioning

confidence: 99%

Contemporary Techniques and Potential Transungual Drug Delivery Nanosystems for The Treatment of Onychomycosis

Abd-Elsalam

Abouelatta

2023

AAPS PharmSciTech

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The humanoid nail is considered an exceptional protective barrier that is formed mainly from keratin. Onychomycosis is the cause of 50% of nail infections that is generally caused by dermatophytes. Firstly, the infection was regarded as a cosmetic problem but because of the tenacious nature of onychomycosis and its relapses, these infections have attracted medical attention. The first line of therapy was the oral antifungal agents which were proven to be effective; nevertheless, they exhibited hepato-toxic side effects, alongside drug interactions. Following, the opportunity was shifted to the topical remedies, as onychomycosis is rather superficial, yet this route is hindered by the keratinized layers in the nail plate. A potential alternative to overcome the obstacle was applying different mechanical, physical, and chemical methods to boost the penetration of drugs through the nail plate. Unfortunately, these methods might be expensive, require an expert to be completed, or even be followed by pain or more serious side effects. Furthermore, topical formulations such as nail lacquers and patches do not provide enough sustaining effects. Recently, newer therapies such as nanovesicles, nanoparticles, and nanoemulsions have emerged for the treatment of onychomycosis that provided effective treatment with possibly no side effects. This review states the treatment strategies such as mechanical, physical, and chemical methods, and highlights various innovative dosage forms and nanosystems developed in the last 10 years with a focus on advanced findings regarding formulation systems. Furthermore, it demonstrates the natural bioactives and their formulation as nanosystems, and the most relevant clinical outcomes. Graphical Abstract

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Section: Metallic Nanoparticlesmentioning

confidence: 99%

Contemporary Techniques and Potential Transungual Drug Delivery Nanosystems for The Treatment of Onychomycosis

Abd-Elsalam

Abouelatta

2023

AAPS PharmSciTech

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Supramolecular Strategy for the Design of Nanocarriers for Drugs and Natural Bioactives: Current State of the Art (A Review)

Zakharova,

Maganova,

Sinyashin

et al. 2023

Russ J Gen Chem

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The review focuses on the lipid based nanocarriers, with special attention paid to natural bioactive payloads. First, micelles and microemulsions are considered as very attractive colloidal nanocontainers that allow for marked improving the solubility of hydrophobic bioactives. Further, liposomal vehicles are reviewed, with both advantages and limitations discussed. Literature assay covers up-to-date information of about last three to five years, although brief background is given on the pioneer works addressing the liposomes and their evolution from bench to bedside. Final part of the review is devoted to the modern modifications of vesicular nanocarriers which can be adapted to specific administration way due to improved targeting properties, permeability, mucoadhesiveness and possibility to cross biological barriers. Therein, such kinds of nanocarriers as transfersomes, niosomes, ethosomes, chitosomes are evaluated; and separate sections focus on the natural based formulations, i.e., phytosomes and invasomes.

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Formulation and Evaluation of Antibacterial and Anti-Inflammatory Emulgel Containing Eugenia caryophyllus Buds Extract

S. Fakir,

M. Ahire,

R. Surana

et al. 2024

Biosci., Biotech. Res. Asia

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Background: Eugenia caryophyllus is a valuable aromatic spice used in household cooking. Traditional healers frequently employ the plant, which is said to have therapeutic qualities, in herbal concoctions to treat a variety of illnesses and conditions. Objective: Eugenia caryophyllus clove buds have antibacterial, analgesic, and anti-inflammatory properties. The formulation of clove emulgel and its assessment using a variety of evaluation criteria were the main objectives of the current study. Clove emulgel was evaluated for its anti-inflammatory and anti-microbial properties. Materials and Procedures: We extracted and assessed the oils from Eugenia caryophyllus buds for phytochemical testing using solvents such as methanol, ethanol, petroleum ether, and N-hexane. We prepare emulgel and test it for spreadability, pH, and other organoleptic characteristics. We used egg albumin denaturation as a protein to measure the in vitro anti-inflammatory efficacy. We tested the antibacterial susceptibility using the agar-well diffusion method. Results: Alkaloids, saponins, tannins, steroids, carbohydrates, and glycosides were the phytochemical components found in clove bud extract. Physical factors such as color, consistency, and state—such as semi-solid, smooth, and brownish-gummy—are included in this category of evaluation parameters. The emulgel's pH was 5.35, its spreadability ranged from 1.6 to 2.5 cm, and no phase separation was noticed while the emulgel was stored. An in vitro anti-inflammatory test (spectroscopy method) and an antimicrobial test (zone of inhibition) were used to evaluate the anti-inflammatory activity of emulgel. Comparing clove oil emulgel to a typical medication, these evaluations found that it demonstrates strong anti-inflammatory and antibacterial resistance. Conclusion: In conclusion, Clove Buds Emulgel has demonstrated antibacterial activity against both gram-positive and gram-negative bacterial strains. Emulgel demonstrated the inhibitory response percentage in relation to the standard. This validates the roles that E. caryophyllus has been shown to play in protecting human health. This innovative emulgel mixture was applied to arthritis to lessen microbial infection and joint discomfort. In addition, more preclinical and clinical trials will be needed for this research in order to successfully commercialize the emulgel formulation for the treatment of inflammation and antimicrobial activity.

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Emulgel: An Emerging Approach towards Effective Topical Drug Delivery

Cited by 5 publications

References 66 publications

Contemporary Techniques and Potential Transungual Drug Delivery Nanosystems for The Treatment of Onychomycosis

Contemporary Techniques and Potential Transungual Drug Delivery Nanosystems for The Treatment of Onychomycosis

Supramolecular Strategy for the Design of Nanocarriers for Drugs and Natural Bioactives: Current State of the Art (A Review)

Formulation and Evaluation of Antibacterial and Anti-Inflammatory Emulgel Containing Eugenia caryophyllus Buds Extract

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