In the context of the rapidly evolving landscape shaped by the increased prevalence of digital technologies and the transformative dynamics of supply chains in the post-COVID-19 era, this research seeks to address a crucial gap by examining the mediating role played by supply chain integration and efficiency. The primary aim is to provide a more comprehensive and nuanced understanding of how digitalization influences networks of supply chain performance. Moreover, we delve into the moderating impact of supply chain dynamism on shaping this association. Through a simple random sampling technique, survey data were collected from 293 Turkish manufacturing firms via an online survey and analyzed using structural equation modeling. The findings underscore that digitalization significantly enhances supply chain integration and efficiency, thereby contributing to improved supply chain performance. Notably, supply chain integration and efficiency were identified as key mediators in the relationship between digitalization and supply chain performance. Furthermore, we investigate the moderating effect of supply chain dynamism, revealing its positive influence on the association between digitalization and supply chain integration. Rooted in key theories such as the resource-based view and dynamic capabilities, this study provides valuable insights by unraveling the intricate processes through which digitalization’s impact is channeled in the post-COVID-19 era. The research extends the current literature by considering the contextual role of supply chain dynamism, shedding light on the complex dynamics between digitalization and supply chain outcomes.