Enamel Matrix Derivative, Alone or Associated With a Synthetic Bone Substitute, in the Treatment of 1‐ to 2‐Wall Periodontal Defects

Leonardis, Dario De; Paolantonio, Michele

doi:10.1902/jop.2012.110656

Cited by 41 publications

(57 citation statements)

References 46 publications

(129 reference statements)

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“…The summary of quality assessment was described in Descriptive data relative to the included twelve studies are reported in months in one study [14].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Only one paper did not report smoking habits [20]. Five drop-outs were reported in three studies [14,34,36]. Patients enrolled in four studies suffered from chronic periodontitis [18, 28, 32, 36], whereas in one study patients suffering from chronic and aggressive periodontitis…”

Section: Patient's Characteristicsmentioning

confidence: 99%

“…In a randomized controlled clinical trial, the application of a non-resorbable titanium-reinforced membrane increased by 7x the probability of obtaining a significant CAL gain of at least 4 mm compared with the application of EMD alone in the treatment of non-contained intrabony defects [13]. Therefore, in order to maximize the clinical outcomes by stabilizing the blood clot and preventing flap collapse, the combination of EMD and bone grafts has been proposed [14,15].…”

Section: Introductionmentioning

confidence: 99%

“…Thus, the available clinical and biological data appear to support the combination of EMD and bone grafts for regenerative treatment in intrabony defects. It is also anticipated that this combination may even yield to synergistic effects where the graft material may act as an osteoconductive scaffold maintaining in the same time the defect space, while EMD may induce formation of root cementum, periodontal ligament and bone [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

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Enamel matrix derivative and bone grafts for periodontal regeneration of intrabony defects. A systematic review and meta-analysis

et al. 2015

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Objective: To assess the clinical efficacy of regenerative periodontal surgery of intrabony defects using a combination of enamel matrix derivative (EMD) and bone graft compared with that of EMD alone. Materials and methods:The Cochrane Oral Health Group specialist trials, MEDLINE and EMBASE databases were searched for entries up to February 2014. The primary outcome was gain of clinical attachment (CAL). Weighted means and Forest plots were calculated for CAL gain, probing depth (PD) and gingival recession (REC).Results: Twelve studies reporting on 434 patients and 548 intrabony defects were selected for the analysis. Mean CAL gain amounted to 3.76 ± 1.07 mm (median 3.63 95% CI: 3.51-3.75) following treatment with a combination of EMD and bone graft and to 3.32±1.04 mm (median 3.40; 95% CI 3.28; 3.52) following treatment with EMD alone. Clinical relevance: The present findings support the use of EMD and bone grafts for the treatment of intrabony periodontal defects.3

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“…The summary of quality assessment was described in Descriptive data relative to the included twelve studies are reported in months in one study [14].…”

Section: Study Characteristicsmentioning

confidence: 99%

Section: Patient's Characteristicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Enamel matrix derivative and bone grafts for periodontal regeneration of intrabony defects. A systematic review and meta-analysis

et al. 2015

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“…Of the 19 studies included, nine had a split-mouth design -six with a follow-up period of 12 months (14,16,23,27,28,34) and three with duration of over 24 months (15,35,36) -and ten had a parallel design -five with a follow-up period of 12 months (10,17,(37)(38)(39) and five with a follow-up period of over 24 months (24,25,29,40,41). Regarding the evaluated outcomes, PD and CAL were evaluated in all the studies, gingival recession (GR) was additionally evaluated in eight studies (15,16,24,25,29,36,39,41) and bone filling in twelve studies (10,(14)(15)(16)(23)(24)(25)27,29,36,39,41).…”

Section: Study Characteristicsmentioning

confidence: 99%

Do the Clinical Effects of Enamel Matrix Derivatives in Infrabony Defects Decrease Overtime? A Systematic Review and Meta-Analysis

Zanatta

Souza²,

Pinto

et al. 2013

Braz. Dent. J.

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Previous systematic reviews have demonstrated better results with enamel matrix derivative proteins (EMDP) as compared with open flap debridement (OFD) for the management of infrabony periodontal defects (IPD). The aim of this study was to determine whether these differences vary according to the follow-up and quality of the studies. Cochrane Central Register of Controlled Trials, Medline/PubMed, Lilacs, Embase and Web of Science electronic databases were searched up to August 2013 for randomized clinical trials.Eligible outcomes were changes in probing depth (PD), clinical attachment level (CAL),gingival recession (GR) and bone changes (BC). Studies with follow-up of 12 months showed differences of 0.97 mm (CI95% 0.52 -1.43) and 1.19 mm (CI95% 0.77 -1.60) for PD and CAL, respectively, favorable for EMDP. Studies with follow-up ≥ 24 months presented advantages of 1.11 mm (CI95% 0.74 -1.48) for CAL and 0.83 mm (CI95% 0.19 -1.48) for PD,with use of EMDP. Considering the quality of studies, those with low risk of bias showed lower difference between groups, presenting 0.8 mm (CI95% 0.24-1.36) for CAL, favorable for EMDP and without differences for PS (0.51 mm, CI95% -0.21 -1.23). In conclusion, follow-up time (< or > 2 years) and the risk of bias influence the results of treatment with EMDP in IPD.

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Impact of adjunctive procedures on recombinant human fibroblast growth factor‐2–mediated periodontal regeneration therapy: A retrospective study

Nakayama

Matsuda

Itoh

et al. 2020

Journal of Periodontology

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Background: Human fibroblast growth factor-2 (rhFGF-2) therapy has been used for periodontal tissue regeneration. However, few studies have reported their adjunctive procedures based on strategy of tissue engineering. The aim of this retrospective study is to assess the adjunctive effects of modified papilla preservation technique (mPPT) and combination with autogenous bone grafts (AG) on the rhFGF-2 therapy. Methods: Total of 44 sites underwent rhFGF-2 therapies and the evaluations in the survey periods. The primary outcome was set to the radiographic bone fill by radiographic examinations at 6 and 12 months after surgeries. We analyzed the correlation between influencing factors and the primary outcome, and differences of therapeutic effect by combination therapy with mPPT and that with AG.Results: After surgeries, probing depth (PD), clinical attachment level (CAL) and bone defects significantly improved. The improvements of radiographic bone fill were significantly positive correlated with a number of bone walls, combination with mPPT, and AG at 6 months after surgeries, and with combination with mPPT and AG at 12 months after surgeries. The significant differences of improvements of radiographic bone fill were demonstrated between combination with or without mPPT at 12 months after surgeries, and with or without AG at 6 and 12 months after surgeries. Moreover, the multiple linear regression analysis for the radiographic bone fill indicated the significant regression coefficient with conducts of mPPT. Conclusions: mPPT and AG had powerfully adjunctive effects on rhFGF-2 therapy. Further studies are needed in order to verify by randomized clinical trials.

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Enamel Matrix Derivative, Alone or Associated With a Synthetic Bone Substitute, in the Treatment of 1‐ to 2‐Wall Periodontal Defects

Abstract: Our data support the hypothesis that the adjunct of an HA/β-TCP composite implant with EMD may improve the clinical and radiographic outcomes of the surgical treatment of unfavorable intrabony defects.

Cited by 41 publications

References 46 publications

Enamel matrix derivative and bone grafts for periodontal regeneration of intrabony defects. A systematic review and meta-analysis

Enamel matrix derivative and bone grafts for periodontal regeneration of intrabony defects. A systematic review and meta-analysis

Do the Clinical Effects of Enamel Matrix Derivatives in Infrabony Defects Decrease Overtime? A Systematic Review and Meta-Analysis

Impact of adjunctive procedures on recombinant human fibroblast growth factor‐2–mediated periodontal regeneration therapy: A retrospective study

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