Enamel mineralization and compositional time-resolution in human teeth evaluated via histologically-defined LA-ICPMS profiles

Müller, Wolfgang; Nava, Alessia; Evans, David; Rossi, Paola Francesca; Alt, Kurt W.; Bondioli, Luca

doi:10.1016/j.gca.2019.03.005

Cited by 56 publications

(125 citation statements)

References 104 publications

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“…1 & 6). Zinc enrichment at the enamel surface has been documented previously using LA-ICP-MS (Humphrey et al, 2008a;Müller et al, 2019). Müller et al (2019) observed Zn/Ca ratios increased nearexponentially some 20-35 times towards outer enamel.…”

Section: Zinc In Enamel and Dentinesupporting

confidence: 56%

“…Zinc enrichment at the enamel surface has been documented previously using LA-ICP-MS (Humphrey et al, 2008a;Müller et al, 2019). Müller et al (2019) observed Zn/Ca ratios increased nearexponentially some 20-35 times towards outer enamel. Zinc exchange from the posteruptive oral environment may well contribute to this surface enrichment (Humphrey et al 2008a) but it is notable in this study that worn enamel, despite having being exposed to saliva, is not Zn rich.…”

Section: Zinc In Enamel and Dentinesupporting

confidence: 56%

“…Zinc exchange from the posteruptive oral environment may well contribute to this surface enrichment (Humphrey et al 2008a) but it is notable in this study that worn enamel, despite having being exposed to saliva, is not Zn rich. Zinc at the enamel surface has also been tentatively linked to the intense involvement of Zn in the process of enamel mineralisation and maturation (Humphrey et al 2008a;Klimuszko et al, 2018;Müller et al, 2019).…”

Section: Zinc In Enamel and Dentinementioning

confidence: 99%

“…This enables slow and controlled thickening of the crystallites during the secretory stage that pack increasingly tightly together within in the deeper enamel and may also fuse together (Robinson et al 1997;Al-Mosawi et al, 2018). MMP-20 contains Zn some of which may conceivably be retained in deeper enamel after proteins are degraded depending on the efficiency with which they may, or may not, be removed from the matrix during the secretory stage (Müller et al, 2019). There is an ongoing bidirectional gradient of enamel mineralisation from the EDJ to the surface enamel and from the cusp tip cervically (Al-Mosawi et al, 2018).…”

Section: Zinc In Enamel and Dentinementioning

confidence: 99%

“…An exception was Mg/Ca that reduced postnatally and Sr/Ca that was bimodal, either remaining the same or rising in one group or falling to lower postnatal levels in a second group. Müller et al (2019) have further investigated underlying trends through pre-and postnatal enamel using LA-ICP-MS and observed a 30-80% decrease in Sr/Ca from the EDJ to the surface enamel that they attributed to the several-fold upregulation of Ca metabolism and active transport of Ca through ameloblasts during enamel maturation. Humphrey et al (2004; also used LA-ICP-MS to sample trace elements in enamel either side of the NNL.…”

Section: Introductionmentioning

confidence: 99%

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Synchrotron X-ray fluorescence mapping of Ca, Sr and Zn at the neonatal line in human deciduous teeth reflects changing perinatal physiology

Dean

Spiers

Garrevoet

et al. 2019

Archives of Oral Biology

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Objectives: Our first objective was to review the evidence describing the appearance and microstructure of the neonatal line and to link this with known changes in neonatal physiology occurring at and around birth. A second objective was to explore ways to improve identification of the neonatal line by mapping the pre-and postnatal distribution of Ca, Sr and Zn in deciduous cuspal enamel and superimposing these maps onto transmitted light micrographs that included a clear true section of the neonatal line. Materials and Methods: We used synchrotron X-ray fluorescence to map elemental distributions in pre-and postnatal enamel and dentine. Two deciduous canines and 5 molars were scanned with an X-ray beam monochromatised to 17.0 keV at either 10.0, 2.5 or 1.0 µm resolution and 10 ms integration time. Results: Calcium maps distinguished enamel and dentine but did not clearly demarcate tissues formed pre-or postnatally. Strontium maps reflected presumed pre-and postnatal maternal serum levels and what are likely to be diet-dependent regions of Sr enrichment or depletion. Prenatal Zn maps, particularly for dentine, mirror elevated levels in the fetus and in colostrum during the first few days of life. Conclusions: The neonatal line, enamel dentine junction and surface enamel were all Zn-rich. Within the neonatal line Zn may be associated with increased crystallinity but also with caries resistance, both of which have been reported previously. Elemental mapping may improve the identification of ambiguous NNLs and so be useful in forensic and archaeological studies.

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Section: Zinc In Enamel and Dentinesupporting

confidence: 56%

Section: Zinc In Enamel and Dentinesupporting

confidence: 56%

Section: Zinc In Enamel and Dentinementioning

confidence: 99%

Section: Zinc In Enamel and Dentinementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Synchrotron X-ray fluorescence mapping of Ca, Sr and Zn at the neonatal line in human deciduous teeth reflects changing perinatal physiology

Dean

Spiers

Garrevoet

et al. 2019

Archives of Oral Biology

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Strontium, oxygen, and carbon isotope variation in modern human dental enamel

Plomp

Holstein

Kootker

et al. 2020

American J Phys Anthropol

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Objectives Isotopic analyses using human dental enamel provide information on the mobility and diet of individuals in forensic and archeological studies. Thus far, no study has systematically examined intraindividual coupled strontium (Sr), oxygen (O), and carbon (C) isotope variation in human enamel or the effect that caries have on the isotopic integrity of the enamel. The inadequate quantification of isotopic variation affects interpretations and may constrain sample selection of elements affected by caries. This study aims to quantify the intraindividual isotopic variation and provides recommendations for enamel sampling methods. Material and Methods This study presents the first systematic results on intraindividual variation in Sr–O–C isotope composition and Sr concentration in modern human dental enamel of third molars (affected and unaffected by caries). A multiloci sampling approach ( n = 6–20) was used to analyze surface and inner enamel, employing thermal ionization mass spectrometry (TIMS) and isotope ratio mass spectrometry (IRMS). Third molars were analyzed from 47 individuals from the Netherlands, Iceland, the United States, the Caribbean, Colombia, Somalia, and South Africa. Results Intradental isotopic variation in modern Dutch dental elements was recorded for Sr, O, and C and exceeded the variation introduced by the analytical error. Single loci and bulk sampling approaches of third molars established that a single analysis is only representative of the bulk Sr isotope composition in 60% of the elements analyzed. Dental elements affected by caries showed twice the variation seen in unaffected dental elements. Caries did not consistently incorporate the isotopic composition of the geographical environment in which they developed. Discussion The isotopic variability recorded in unaffected inner enamel indicates that variations greater than 0.000200 for 87 Sr/ 86 Sr and larger than 2‰ for δ 18 O and δ 13 C are required to demonstrate changes in modern Dutch human diet or geographic location.

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The “weanling's dilemma” revisited: Evolving bodies of evidence and the problem of infant paleodietary interpretation

Kendall

Millard

Beaumont

2021

American J Phys Anthropol

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Breastfeeding is known to be a powerful mediator of maternal and childhood health, with impacts throughout the life course. Paleodietary studies of the past 30 years have accordingly taken an enduring interest in the health and diet of young children as a potential indicator of population fertility, subsistence, and mortality patterns.While progress has been made in recent decades toward acknowledging the agency of children, many paleodietary reconstructions have failed to incorporate developments in cognate disciplines revealing synergistic dynamics between maternal and offspring biology. Paleodietary interpretation has relied heavily on the "weanling's dilemma," in which infants are thought to face a bleak choice between loss of immunity or malnutrition. Using a review of immunological and epidemiological evidence for the dynamic and supportive role that breastfeeding plays throughout the complementary feeding period, this article offers context and nuance for understanding past feeding transitions. We suggest that future interpretative frameworks for infant paleodietary and bioarchaeological research should include a broad knowledge base that keeps pace with relevant developments outside of those disciplines.

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Enamel mineralization and compositional time-resolution in human teeth evaluated via histologically-defined LA-ICPMS profiles

Cited by 56 publications

References 104 publications

Synchrotron X-ray fluorescence mapping of Ca, Sr and Zn at the neonatal line in human deciduous teeth reflects changing perinatal physiology

Synchrotron X-ray fluorescence mapping of Ca, Sr and Zn at the neonatal line in human deciduous teeth reflects changing perinatal physiology

Strontium, oxygen, and carbon isotope variation in modern human dental enamel

The “weanling's dilemma” revisited: Evolving bodies of evidence and the problem of infant paleodietary interpretation

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