Encapsulated melatonin in polycaprolactone (PCL) microparticles as a promising graft material

Gürler, Esra Bihter; Ergul, Necdet Mekki; Ozbek, Burak; Ekren, Nazmi; Oktar, Faik N.; Hasköylü, Merve Ergįner; Öner, Ebru Toksoy; Eroğlu, Mehmet S.; Özbeyli, Dilek; Korkut, Veysel; Temiz, Ahmet Furkan; Kocanalı, Nil; Gungordu, Rosa Juvan; Kılıckan, Duhan Berkan; Gündüz, Oğuzhan

doi:10.1016/j.msec.2019.03.051

Cited by 27 publications

(15 citation statements)

References 43 publications

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“…The results displayed that endothermic peak of MLT was observed at about 116°C, which is due to the melting of MLT, revealing its crystalline structure. Previous studies indicated a remarkable endothermic peak of MLT at 119°C [ 34 ]; this result was basically consistent with the literature results. And there was disappearance of melting endotherm peak of MLT in elastic liposomes; this may be due to the existence of certain interactions in the elastic liposomes, which led to the disappearance of the melting peak and the change of the crystal structure of MLT.…”

Section: Resultssupporting

confidence: 92%

“…The IR spectrum of MLT-laden elastic liposomes was greatly similar to the blank elastic liposomes, whereas it was distinctly different from that of the MLT power. The FTIR spectrum of MLT stretching peaks was determined at 3333.59 cm −1 , 1625 cm −1 , and 1210 cm −1 associated with the functional N-H stretch, C=O, and C-N, respectively [ 34 , 35 ]. However, these typical peaks disappeared in the spectrum of the elastic liposomes.…”

Section: Resultsmentioning

confidence: 99%

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Application and Efficacy of Melatonin Elastic Liposomes in Photoaging Mice

Hou

Qiu

Wang

et al. 2022

Oxidative Medicine and Cellular Longevity

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Transdermal drug delivery system is a preferable choice to overcome the low bioavailability of oral medication. Elastic liposomes have shown great effectiveness for percutaneous transport of melatonin (MLT). In this study, the elastic liposomes loaded with MLT were prepared using thin-film dispersion method and optimized through the central composite design (CCD) approach. The physicochemical properties and skin permeation against UV-induced skin photoaging efficacy of the developed MLT-ELs were assessed. The average size of the MLT-ELs was about 49 nm with a spherical shape and high encapsulation efficiency (73.91%) and drug loading (9.92%). The results of FTIR, DSC, and XRD revealed that the chemical structure of MLT was not changed after prepared elastic liposomes, and the drug was successfully encapsulated in the elastic liposome membrane material. In vitro skin permeation evaluation showed that the cumulative penetration of elastic liposomes was 1.5 times higher than that of conventional liposomes, highlighting that the elastic liposomes more easily penetrated into the body. The photoaging experiment results indicated that topical MLT-EL treatment ameliorated the skin elasticity, enhanced the skin hydration level, and preserved the integrity of dermal collagen and elastic fibers. It could be concluded that the elastic liposomes might serve as a promising platform for the transdermal delivery of melatonin.

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Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Application and Efficacy of Melatonin Elastic Liposomes in Photoaging Mice

Hou

Qiu

Wang

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…Electrospraying is a technique used to produce particulate bone graft materials. They have been identified to enable rapid and cost‐effective production of microparticles 135 . Coaxial electrospraying has been used to produce microspheres of poly (lactic‐co‐glycolic acid) (PLGA) loaded with rhBMP‐2 obtaining microspheres with minute diameters 197 .…”

Section: Classificationmentioning

confidence: 99%

“…These particles have depicted promising osteogenic behavior in vitro. Electrospray microparticles of PCL encapsulated with melatonin hormone exhibited high levels of bone remodeling and new bone formation in vivo 135 …”

Section: Classificationmentioning

confidence: 99%

A novel classification of bone graft materials

2022

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Over the past few decades, the field of biomaterials concerning bone tissue engineering has gained a significant amount of interest. This has led to new biomaterials to be used as bone substitute materials. Despite the rapid increase in the types and forms of bone substitutes, a comprehensive classification encompassing all types of bone graft materials that have so far been developed and evaluated is lacking. Therefore, this review aims to integrate and bring together the published data on bone substitutes within the last 5 years and produce a novel classification that would provide bone material researchers with a better understanding of what materials have so far been used and evaluated and the areas, where research is lacking and deserves more attention. The literature available in all major databases was obtained and filtered using an elimination criterion to extract all the articles related to studies that tested bone substitute materials in nonclinical and clinical trials over the last 5 years. The review article would provide bone material researchers with an insight into the materials that have been evaluated for bone tissue engineering applications and identify future perspectives for bone graft material research.

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“…For melatonin encapsulation, a 3 wt % PCL solution was used, and particles with diameter size of 2.3 ± 0.64 µm were obtained (EE: 73%). These NPs allowed a prolonged release of melatonin for about 8 h. By analyzing in vitro (primary human osteoblasts cells) and in vivo (female Sprague Dawley animals) behavior of grafted materials, Gurler and colleagues identified a remarkable increase in both cell population and bone volume of rats, indicating melatonin-loaded PCL NPs as an optimal electrospray method to improve the therapeutic efficacy of synthetic engraftment [122].…”

Section: Polycaprolactone/melatoninmentioning

confidence: 99%

Melatonin-Loaded Nanocarriers: New Horizons for Therapeutic Applications

et al. 2021

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The use of nanosized particles has emerged to facilitate selective applications in medicine. Drug-delivery systems represent novel opportunities to provide stricter, focused, and fine-tuned therapy, enhancing the therapeutic efficacy of chemical agents at the molecular level while reducing their toxic effects. Melatonin (N-acetyl-5-methoxytriptamine) is a small indoleamine secreted essentially by the pineal gland during darkness, but also produced by most cells in a non-circadian manner from which it is not released into the blood. Although the therapeutic promise of melatonin is indisputable, aspects regarding optimal dosage, biotransformation and metabolism, route and time of administration, and targeted therapy remain to be examined for proper treatment results. Recently, prolonged release of melatonin has shown greater efficacy and safety when combined with a nanostructured formulation. This review summarizes the role of melatonin incorporated into different nanocarriers (e.g., lipid-based vesicles, polymeric vesicles, non-ionic surfactant-based vesicles, charge carriers in graphene, electro spun nanofibers, silica-based carriers, metallic and non-metallic nanocomposites) as drug delivery system platforms or multilevel determinations in various in vivo and in vitro experimental conditions. Melatonin incorporated into nanosized materials exhibits superior effectiveness in multiple diseases and pathological processes than does free melatonin; thus, such information has functional significance for clinical intervention.

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Encapsulated melatonin in polycaprolactone (PCL) microparticles as a promising graft material

Cited by 27 publications

References 43 publications

Application and Efficacy of Melatonin Elastic Liposomes in Photoaging Mice

Application and Efficacy of Melatonin Elastic Liposomes in Photoaging Mice

A novel classification of bone graft materials

Melatonin-Loaded Nanocarriers: New Horizons for Therapeutic Applications

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