Encapsulation and isomerization of curcumin with cyclodextrins characterized by electronic and vibrational spectroscopy

Vacuum curcumin infusion in cooked oysters (Crassostrea gigas) to increase their shelf life

“…The peaks 1,249 cm −1 , 1,180 cm −1 , and 960 cm −1 almost disappeared in the CurTween solution according Figure a. It is happed probably due a possible isomerization of ν (CO) change to diketo form (del Castillo, López‐Tobar, Sanchez‐Cortes, Flores, & Blanch, ; López‐Tobar et al, ). For the other curcumin solutions, the signals at 1,249, 1,150 and 960 cm −1 were maintained.…”

“…The peaks located from 1,530 to 1,430 cm −1 in the Raman spectra show a group of three well‐defined weak bands that correspond to the methyl groups coupled to ring motions (López‐Tobar, Blanch, Ruiz Del Castillo, & Sanchez‐Cortes, ). The band at 1,430 cm −1 keeps its position and does not undergo changes in CurWine and CurEthanol solutions, indicating that the methoxy group was preserved.…”

Selection and optimization of nano-formulation of P-glycoprotein inhibitor for reversal of doxorubicin resistance in COLO205 cells

“…In a subsequent step for improving dispersibility of Cur, numerous approaches have been developed such as encapsulation into cyclodextrin, nano‐emulsification, nano‐encapsulation using polymer or lipids . Out of these, simplest and effective approach is to encapsulate it into cyclodextrins (in a molecular stoichiometry of 1 : 1, 1 : 2 or 1 : 4) . These complexes have indeed improved the solubility of Cur and resultantly improved its activity in various cancers such as ovarian cancer, squamous cell carcinoma and other inflammatory conditions.…”

“…[27][28][29] Out of these, simplest and effective approach is to encapsulate it into cyclodextrins (in a molecular stoichiometry of 1 : 1, 1 : 2 or 1 : 4). [30,31] These complexes have indeed improved the solubility of Cur and resultantly improved its activity in various cancers such as ovarian cancer, squamous cell carcinoma and other inflammatory conditions [30,32,33] . However, frustratingly the EE of complexed form barely varies between 1 and 5% at different experimental conditions.…”

Structure and Mechanism of Action of Tau Aggregation Inhibitors

“…The enol form, which is more stable than the keto form by ~20 kJ/mol [119], is more polarizable in the ground state and presents a flat surface for interaction with binding partners. In contrast, the keto form has reduced resonance owing to breakage of electronic delocalization [120]. These characteristics appear as a more even distribution of surface electrostatic potential and electronic density in the enol form versus the keto form (Fig.…”