Encapsulation artocarpanone and ascorbic acid in O/W microemulsions: Preparation, characterization, and antibrowning effects in apple juice

Dong, Xue; Zhu, Qin; Dai, Yaqing; He, Jianfei; Pan, Hong; Chen, Jie; Zheng, Zong‐Ping

doi:10.1016/j.foodchem.2015.07.124

Cited by 41 publications

(7 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3) Furthermore, the produced dopaquinone is highly reactive and can further spontaneously polymerize to generate brown pigments of high molecular weight, namely melanin, 4,5) which are responsible for the color of mammalian skin and hair and also plays an important role in the protection of the skin against UV light induced damage. [6][7][8][9][10] Despite these good physiological functions demonstrated by this enzyme, the overproduction of melanin would cause not only serious dermatological problems such as melasma, freckles, senile lentigines, age spots, and sites of actinic damage in human beings. 11) but also the undesired enzymatic browning of fruits and vegetables.…”

Section: Introductionmentioning

confidence: 99%

Study on Synthesis and Biological Evaluation of 3-Aryl Substituted Xanthone Derivatives as Novel and Potent Tyrosinase Inhibitors

Chen

Luo

et al. 2019

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

Tyrosinase plays a key role in the melanin biosynthesis since it catalyzes the transformation of tyrosine into L-dopaquinone. A large number of studies have also shown that molecules to efficiently inhibit the activity of tyrosinase would be potentially used in treating many depigmentation-related disorders. In this study, we targeted a series of structure-based 3-aryl substituted xanthone derivatives in which diverse functional groups were respectively attached on 3-aromatic ring moiety as new tyrosinase inhibitors. The results demonstrated that all obtained compounds had potent tyrosinase inhibitory activities with IC 50 values at micromolar range. Especially, compound 4t was found to be the most active tyrosinase inhibitor with the IC 50 value of 11.3 µM, uncovering that the introduction of the proper hydroxyl group in the 3-aromatic ring was beneficial for enhancing the inhibitory potency against tyrosinase. Moreover, the inhibition mechanism and inhibition kinetics studies revealed that compound 4t presented such inhibitory effect by acting as the reversible and competitive-uncompetitive mixed-II type inhibitor. Further molecular docking simulation showed that 3-aromatic ring of compound 4t was inserted into the narrow regions of binuclear copper-binding site at the bottom of the enzyme binding pocket, while the xanthone skeleton was positioned at the surface of tyrosinase. Taken together, these data suggested that such type of molecules might be utilized for the development of new and promising candidate for the treatment of depigmentation-related disorders.

show abstract

Section: Introductionmentioning

confidence: 99%

Study on Synthesis and Biological Evaluation of 3-Aryl Substituted Xanthone Derivatives as Novel and Potent Tyrosinase Inhibitors

Chen

Luo

et al. 2019

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

show abstract

“…Pseudoternary phase diagram was constructed using water titration method in order to locate the microemulsion region and obtain the concentration range of oil, surfactant, co‐surfactant, and water in the region (Dong et al, ; Zhao et al, ). First of all, surfactant was mixed with co‐surfactant at a weight ratio ( S mix ) of 10:1.…”

Section: Methodsmentioning

confidence: 99%

Self‐microemulsifying oral fast dissolving films of vitamin D3 for infants: Preparation and characterization

Zhang

Zou

et al. 2019

Food Science & Nutrition

View full text Add to dashboard Cite

Combining the advantages of self‐microemulsifying technology and oral fast dissolving technology, a self‐microemulsifying oral fast dissolving films (SMEOFDF) of vitamin D3 was developed in this study. The pseudoternary phase diagram of microemulsion was constructed using water titration method, and the formulation of films was optimized by orthogonal experimental design. The prepared SMEOFDF of vitamin D3 was a thin film, in which the liquid drops of self‐microemulsion were embedded. It had good mechanical properties (thickness 166.7 ± 3.30 µm, tensile strength 38.45 ± 3.72 MPa, elongation 23.38 ± 4.23%, and folding endurance >200 times), and its disintegration time was about 18 ± 1.23 s. After being redissolved in water, microemulsion could form spontaneously, with particle size of 181.2 nm and zeta potential of 16.1 mV. The release profile of vitamin D from SMEOFDF could be well described by first‐order equation.

show abstract

“…In this method, mixture of co-surfactant, surfactant and aqueous phase are added. In small quality of oil are added in vial and vortexing the mixture at different time interval at optimized temperature [61].…”

Section: Phase Titration Methodsmentioning

confidence: 99%

Therapeutic challenges in ocular delivery of lipid based emulsion

Tiwari

Pandey

Asati

et al. 2018

Egyptian Journal of Basic and Applied Sciences

View full text Add to dashboard Cite

In the last decade, lipid based emulsions (LEs) have emerged as a novel tool in ophthalmic drug delivery from the aspect of improved bioavailability (BA). Recent research is focuses on two main approaches for BA improvement i.e., by enhancing the corneal permeability and increasing the retention time of drug on the ocular surface. The LEs have great potential to delivery hydrophobic drug because drug molecules get dissolve in oil globule and main advantage associated are reduced toxic effect and improved self-life of drug molecule. Ophthalmic drug delivery is always an interesting and challenging task for the pharmacologists and formulation scientists due to the unique structure of eye. Development of drug delivery system and its delivery to target receptor of the eye is very difficult for scientists due to the strong defense mechanism of eye. In this review, the focus is to explore key concepts of ophthalmic drug delivery with emphasis on the defense mechanisms, design considerations, and safety assessment of LEs for the ocular drug delivery.

show abstract

Encapsulation artocarpanone and ascorbic acid in O/W microemulsions: Preparation, characterization, and antibrowning effects in apple juice

Cited by 41 publications

References 26 publications

Study on Synthesis and Biological Evaluation of 3-Aryl Substituted Xanthone Derivatives as Novel and Potent Tyrosinase Inhibitors

Study on Synthesis and Biological Evaluation of 3-Aryl Substituted Xanthone Derivatives as Novel and Potent Tyrosinase Inhibitors

Self‐microemulsifying oral fast dissolving films of vitamin D3 for infants: Preparation and characterization

Therapeutic challenges in ocular delivery of lipid based emulsion

Contact Info

Product

Resources

About