Encapsulation strategies for improving the biological behavior of CdS@ZIF-8 nanocomposites

Abstract

Herein we report encapsulation approaches for Cadmium Sulfide (CdS) encapsulated zeolitic imidazolate framework (ZIF)-8 (CdS@ZIF-8), such as “bottle-around-the-ship” and “ship-in-the-bottle.” In this study, these composites were evaluated for antibacterial and DNA-binding properties. To the best of our knowledge, this is the first report on the synthesis of CdS nanoparticles using ZIF-8 as a capping agent. The as-synthesized nanocomposites were characterized using Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis (TGA), Brunauer–Emmett–Teller surface area analysis, field emission-scanning electron microscopy, and high-resolution transmission electron microscopy. Characterization studies revealed that both encapsulation approaches provided different morphologies to the encapsulated framework. The antibacterial activity of the as-fabricated nanocomposite, in which ZIF-8 acts as a capping agent, was more effective against Escherichia coli (E. coli) than Staphylococcus aureus (S. aureus) and Bacillus subtilis (B. subtilis). Furthermore, DNA-binding studies of nanocomposites performed by UV absorption spectroscopic titration method in E. coli genomic DNA indicated that DNA binding occurs along with cleavage. Therefore, the designed nanocomposites demonstrate great promise for future anticancer research.

Triphenylphosphonium-Functionalized Gold Nanorod/Zinc Oxide Core–Shell Nanocomposites for Mitochondrial-Targeted Phototherapy

“…In contrast, the TG/DTA curves of the GNR@ZnO core–shell nanocomposites demonstrated a high thermal stability up to 320 °C. Thermal decomposition appears to occur between 320 and 330 °C, which corresponds to the decomposition of the GNR@ZnO core–shell nanocomposites [ 48 ].…”

“…The TG/DTA curves of the CTAB and GNR were stable up to 230 • C. The decomposition between 230 • C and 242 • C corresponds to the degradation of the capping agent CTAB, which prevents uncontrolled growth and agglomeration of the GNR [47]. In contrast, the TG/DTA curves of the GNR@ZnO core-shell nanocomposites demonstrated a high thermal stability up to 320 • C. Thermal decomposition appears to occur between 320 and 330 • C, which corresponds to the decomposition of the GNR@ZnO core-shell nanocomposites [48].…”

“…In contrast, the TG/DTA curves of GNR@ZnO core-shell nanocomposites demonstrated a high thermal stability up to °C. Thermal decomposition appears to occur between 320 and 330 °C, which correspo to the decomposition of the GNR@ZnO core-shell nanocomposites [48]. The optical properties of the GNR, GNR@ZnO at various temperatures (200, 250, 300, and 400 • C), CTPP, and CTPP-GNR@ZnO core-shell nanocomposites (300 • C) were further characterized by a Shimadzu UV-2600 spectrophotometer (Figure 4a,b).…”