Encephalitis due to a Hantavirus Infection

Case report: Severe neurological manifestation of dobrava hantavirus infection

“…Intrathecal production of specific antibodies was also reported in a patient with encephalitis during the course of HFRS due to Puumala virus [Bergman et al, 2002]. However, in another study on Puumala virus infected HFRS patients with neurological manifestations, no evidence for the presence of Puumala virus in the CNS was found [Ahlm et al, 1998].…”

“…In contrast, in a review of 811 patients with Puumala virus infection in Western Russia only two patients exhibited epileptic seizures and one patient had cerebral hemorrhage [Alexeyev and Morozov, 1995]. There have been also case reports on encephalitis, cerebral hemorrhage, Guillian-Barré syndrome, panhypopituitarism, and acute disseminated encephalomyelitis in patients with Puumala virus associated HFRS [Esselink et al, 1994;Alexeyev and Morozov, 1995;Ahlm et al, 1998;Bergman et al, 2002;Markotić et al, 2002;Toivanen et al, 2002]. Information on the clinical course of HFRS due to infection with Dobrava virus is much more limited and only a few cases with pronounced neurological manifestation have been documented [Avšič-Ž upanc et al, 1999;Markotić et al, 2002].…”

Hantavirus pulmonary syndrome: encephalitis caused by virus Andes

“…There were described cases of encephalitis in the Old World hantaviruses (Puumala, Dobrava, and Hantaan virus) (Bergmann et al 2002;Cerar et al 2007). …”

“…The incidence of encephalitis in HFRS is around 1% (Bergmann et al 2002). Transverse myelitis and acute disseminated encephalomyelitis (ADEM)-like syndrome have been previously attributed to complications following HPS in USA (Huisa et al 2009).…”

Verbreitung von Hantavirusinfektionen in Deutschland

“…Diese in Deutschland beobachtete weniger schwere Form des HFRS führt kaum zu hämorrhagischen Komplikationen. Extrarenale Manifestationen kön-nen eine Begleithepatitis umfassen, vereinzelt wurde auch von einer Myokarditis sowie von Beteiligungen der Lunge [30,57,59,60] oder des zentralen Nervensystems [61] berichtet.…”