Encyclopedia of the Alkaloids

Glasby, John S.

doi:10.1007/978-1-4615-8807-8

Cited by 10 publications

(7 citation statements)

References 3 publications

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“…The first alkaloid identified from Aconitum species was aconitine (AC), which was isolated by Geiger et al . in 1833 [39]. Systematic investigation of the Aconitum alkaloids was initiated in 1936 by Jacobs,[40] who published more than 20 articles on the subject.…”

Section: Phytochemistrymentioning

confidence: 99%

“…The first alkaloid identified from Aconitum species was aconitine (AC), which was isolated by Geiger et al in 1833. [39] Systematic investigation of the Aconitum alkaloids was initiated in 1936 by Jacobs, [40] who published more than 20 articles on the subject. The alkaloids benzoylmesaconine, mesaconitine (MA), AC, hypaconitine (HA), heteratisine, heterophyllisine, heterophylline, heterophyllidine, atidine, isotisine, hetidine, hetsinone and benzoylheteratisine have been isolated from tuberous roots of genus Aconitum.…”

Section: Alkaloidsmentioning

confidence: 99%

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A review on phytochemistry, pharmacology and toxicology studies of Aconitum

Eric

et al. 2015

Journal of Pharmacy and Pharmacology

196

132

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Objectives A number of species belonging to herbal genus Aconitum are wellknown and popular for their medicinal benefits in Indian, Vietnamese, Korean, Japanese, Tibetan and Chinese systems of medicine. It is a valuable drug as well as an unpredictable toxic material. It is therefore imperative to understand and control the toxic potential of herbs from this genus. In this review, the ethnomedicinal, phytochemistry, pharmacology, structure activity relationship and toxicology studies of Aconitum were presented to add to knowledge for their safe application. Key findings A total of about 76 of all aconite species growing in China and surrounding far-east and Asian countries are used for various medical purposes. The main ingredients of aconite species are alkaloids, flavonoids, free fatty acids and polysaccharides. The tuberous roots of genus Aconitum are commonly applied for various diseases such as rheumatic fever, painful joints and some endocrinal disorders. It stimulates the tip of sensory nerve fibres. These tubers of Aconitum are used in the herbal medicines only after processing. There remain high toxicological risks of the improper medicinal applications of Aconitum. The cardio and neurotoxicities of this herb are potentially lethal. Many analytical methods have been reported for quantitatively and qualitatively characterization of Aconitum. Summary Aconitum is a plant of great importance both in traditional medicine in general and in TCM in particular. Much attention should be put on Aconitum because of its narrow therapeutic range. However, Aconitum's toxicity can be reduced using different techniques and then benefit from its pharmacological activities. New methods, approaches and techniques should be developed for chemical and toxicological analysis to improve its quality and safety.

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Section: Phytochemistrymentioning

confidence: 99%

Section: Alkaloidsmentioning

confidence: 99%

A review on phytochemistry, pharmacology and toxicology studies of Aconitum

Eric

et al. 2015

Journal of Pharmacy and Pharmacology

196

132

View full text Add to dashboard Cite

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“…The desired pharmacological properties of Aconitum species are due to a collection of C 20 , C 19 , and C 18 diterpene alkaloids . The C 19 diterpene aconitine ( 6 ) was the first alkaloid identified from Aconitum plants in 1833 by Geiger . The aconitine core scaffold is conserved over 70 structurally unique bioactive alkaloids .…”

Section: Receptor Site IImentioning

confidence: 99%

Natural Voltage‐Gated Sodium Channel Ligands: Biosynthesis and Biology

Lukowski

Narayan

2019

ChemBioChem

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Natural product biosynthetic pathways are composed of enzymes that use powerful chemistry to assemble complex molecules. Small molecule neurotoxins are examples of natural products with intricate scaffolds which often have high affinities for their biological targets. The focus of this Minireview is small molecule neurotoxins targeting voltage‐gated sodium channels (VGSCs) and the state of knowledge on their associated biosynthetic pathways. There are three small molecule neurotoxin receptor sites on VGSCs associated with three different classes of molecules: guanidinium toxins, alkaloid toxins, and ladder polyethers. Each of these types of toxins have unique structural features which are assembled by biosynthetic enzymes and the extent of information known about these enzymes varies among each class. The biosynthetic enzymes involved in the formation of these toxins have the potential to become useful tools in the efficient synthesis of VGSC probes.

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“…1A) and canadine ( Fig. 1B) are protoberberine alkaloids [1]. Together they were isolated from several plants, e.g., Corydalis cheilantheifolia Hemsl.…”

Section: Introductionmentioning

confidence: 97%

Adsorption and Reduction of Berberine at a Mercury Electrode

Komorsky‐Lovrić

2000

Electroanalysis

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Adsorption and reduction of berberine are investigated by alternating current polarography and square-wave voltammetry in electrolytes of various pH. Both berberine and the product of its reduction canadine form condensed ®lms on the mercury electrode surface. These processes limit the analytical application of square-wave voltammetry combined with adsorptive accumulation of berberine. Reduction of berberine is totally irreversible and occurs between À0.95 V and À1.35 V, depending on berberine concentration and pH of solution. Canadine is electroinactive and can not be reoxidized on mercury electrode. Its condensed ®lm is very stable, even at À0.5 V, and may prevent adsorption of berberine. The properties of square-wave voltammetric responses of berberine in acidic, neutral and basic electrolytes are reported and the conditions for their electroanalytical application are discussed.

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Encyclopedia of the Alkaloids

Cited by 10 publications

References 3 publications

A review on phytochemistry, pharmacology and toxicology studies of Aconitum

A review on phytochemistry, pharmacology and toxicology studies of Aconitum

Natural Voltage‐Gated Sodium Channel Ligands: Biosynthesis and Biology

Adsorption and Reduction of Berberine at a Mercury Electrode

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