End-Sealed High Aspect Ratio Hollow Nanotubes Encapsulating an Anticancer Drug: Torpedo-Shaped Peptidic Nanocapsules

Ueda, Mitsuru; Seo, Si‐Yoong; Nair, Baiju G.; Müller, Stefan; Takahashi, Eiki; Arai, Takashi; Iyoda, Tomonori; Fujii, Shota; Tsuneda, Satoshi; Ito, Yoshihiro

doi:10.1021/acsnano.8b06189

Cited by 32 publications

(52 citation statements)

References 34 publications

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“…A ‘patched’ hollow peptide tube can be engineered by mixing two types of peptides, which individually self-assemble into tubular and spherical structures, respectively. The hollow tube is sealed on both ends by half-spheres 146 , and can be applied as a drug-encapsulating vehicle, enabling extravasation into tumour tissue, comparable to other rod-like nanocarriers.…”

Section: Multifunctional Nanostructuresmentioning

confidence: 99%

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Multifunctional biomolecule nanostructures for cancer therapy

2021

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Biomolecule-based nanostructures are inherently multifunctional and harbour diverse biological activities, which can be explored for cancer nanomedicine. The supramolecular properties of biomolecules can be precisely programmed for the design of smart drug delivery vehicles, enabling efficient transport in vivo, targeted drug delivery and combinatorial therapy within a single design. In this Review, we discuss biomolecule-based nanostructures, including polysaccharides, nucleic acids, peptides and proteins, and highlight their enormous design space for multifunctional nanomedicines. We identify key challenges in cancer nanomedicine that can be addressed by biomolecule-based nanostructures and survey the distinct biological activities, programmability and in vivo behaviour of biomolecule-based nanostructures. Finally, we discuss challenges in the rational design, characterization and fabrication of biomolecule-based nanostructures, and identify obstacles that need to be overcome to enable clinical translation.

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Section: Multifunctional Nanostructuresmentioning

confidence: 99%

“…To explore the multifunctional advantage of nanomaterials, systems with highly sophisticated spatial structures and responsive mechanisms have been designed 100 , 101 , 146 . However, accurate and reproducible fabrication methods for such complex structures remain limited.…”

Section: Perspectivesmentioning

confidence: 99%

Multifunctional biomolecule nanostructures for cancer therapy

2021

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“…The use of peptide-based torpedo-shaped hollow capsules for the delivery of the model anticancer drug: cisplatin. (Adapted with permission from Ueda et al [148] Copyright © 2019, American Chemical Society.) (Online version in colour.)…”

Section: Recent Advances In Complex Hollow Nanostructured Materials Fmentioning

confidence: 99%

“…Recently, peptide-based hollow capsules of variable lengths have been reported as containers for the encapsulation of the model anticancer drug, cisplatin (figure 15). It was observed that the unique shape and high aspect ratio of the capsules provided a fast-cellular uptake and higher accumulation at the tumour site when compared with spherical particles [148].…”

Section: Recent Advances In Complex Hollow Nanostructured Materials Fmentioning

confidence: 99%

The controlled synthesis of complex hollow nanostructures and prospective applications

et al. 2019

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Functionality in nanoengineered materials has been usually explored on structural and chemical compositional aspects of matter that exist in such solid materials. It is well known that the absence of solid matter is also relevant and the existence of voids confined in the nanostructure of certain particles is no exception. Indeed, over the past decades, there has been great interest in exploring hollow nanostructured materials that besides the properties recognized in the dense particles also provide empty spaces, in the sense of condensed matter absence, as an additional functionality to be explored. As such, the chemical synthesis of hollow nanostructures has been driven not only for tailoring the size and shape of particles with well-defined chemical composition, but also to achieve control on the type of hollowness that characterize such materials. This review describes the state of the art on late developments concerning the chemical synthesis of hollow nanostructures, providing a number of examples of materials obtained by distinct strategies. It will be apparent by reading this progress report that the absence of solid matter determines the functionality of hollow nanomaterials for several technological applications.

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“…We previously reported that nanotubes with a uniform diameter of ca. 80 nm were prepared from an amphiphilic block copolypeptide, PSar n - b -( l -Leu-Aib) 6 (SL12) with a hydrophobic α-helix composed of the LxLxLxLxLxLx sequence, which involves two LxxxLxxxL sequences [ 20 , 21 ]. The phenomenon was explained by the hypothesis that the helical part is uniformly packed in a hydrophobic layer due to the concave–convex interaction between helices with the LxxxLxxxL sequence [ 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Tubular Assembly Formation Induced by Leucine Alignment along the Hydrophobic Helix of Amphiphilic Polypeptides

Abosheasha

Itagaki

Ito

et al. 2021

IJMS

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The introduction of α-helical structure with a specific helix–helix interaction into an amphipathic molecule enables the determination of the molecular packing in the assembly and the morphological control of peptide assemblies. We previously reported that the amphiphilic polypeptide SL12 with a polysarcosine (PSar) hydrophilic chain and hydrophobic α-helix (l-Leu-Aib)6 involving the LxxxLxxxL sequence, which induces homo-dimerization due to the concave–convex interaction, formed a nanotube with a uniform 80 nm diameter. In this study, we investigated the importance of the LxxxLxxxL sequence for tube formation by comparing amphiphilic polypeptide SL4A4L4 with hydrophobic α-helix (l-Leu-Aib)2-(l-Ala-Aib)2-(l-Leu-Aib)2 and SL12. SL4A4L4 formed spherical vesicles and micelles. The effect of the LxxxLxxxL sequence elongation on tube formation was demonstrated by studying assemblies of PSar-b-(l-Ala-Aib)-(l-Leu-Aib)6-(l-Ala-Aib) (SA2L12A2) and PSar-b-(l-Leu-Aib)8 (SL16). SA2L12A2 formed nanotubes with a uniform 123 nm diameter, while SL16 assembled into vesicles. These results showed that LxxxLxxxL is a necessary and sufficient sequence for the self-assembly of nanotubes. Furthermore, we fabricated a double-layer nanotube by combining two kinds of nanotubes with 80 and 120 nm diameters—SL12 and SA2L12A2. When SA2L12A2 self-assembled in SL12 nanotube dispersion, SA2L12A2 initially formed a rolled sheet, the sheet then wrapped the SL12 nanotube, and a double-layer nanotube was obtained.

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End-Sealed High Aspect Ratio Hollow Nanotubes Encapsulating an Anticancer Drug: Torpedo-Shaped Peptidic Nanocapsules

Cited by 32 publications

References 34 publications

Multifunctional biomolecule nanostructures for cancer therapy

Multifunctional biomolecule nanostructures for cancer therapy

The controlled synthesis of complex hollow nanostructures and prospective applications

Tubular Assembly Formation Induced by Leucine Alignment along the Hydrophobic Helix of Amphiphilic Polypeptides

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