End-tidal Sevoflurane and Halothane Concentrations during Simulated Airway Occlusion in Healthy Humans

Talbot, Nick P.; Farmery, Andrew D.; Dorrington, Keith L.

doi:10.1097/aln.0b013e3181ac1d7b

Cited by 5 publications

(2 citation statements)

References 21 publications

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“…One study showed that sevoflurane (with its lower solubility and slower redistribution) was found to decline three times slower than halothane, resulting in slower wake-up time. (61) Another study showed faster wake-up time with sevoflurane.…”

Section: Awake or Asleep Intubationmentioning

confidence: 99%

Anaesthetic management of acute airway obstruction

Wong¹,

Wong²,

Mok³

2016

smedj

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The acutely obstructed airway is a medical emergency that can potentially result in serious morbidity and mortality. Apart from the latest advancements in anaesthetic techniques, equipment and drugs, publications relevant to our topic, including the United Kingdom's 4th National Audit Project on major airway complications in 2011 and the updated American Society of Anesthesiologists' difficult airway algorithm of 2013, have recently been published. The former contained many reports of adverse events associated with the management of acute airway obstruction. By analysing the data and concepts from these two publications, this review article provides an update on management techniques for the acutely obstructed airway. We discuss the principles and factors relevant to the decision-making process in formulating a logical management plan.

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Section: Awake or Asleep Intubationmentioning

confidence: 99%

Anaesthetic management of acute airway obstruction

Wong¹,

Wong²,

Mok³

2016

smedj

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“…Although modern practice suggests sevoflurane is now the drug of choice for inhalational induction, studying the influence of blood solubility during simulated airway occlusion in healthy volunteers suggests otherwise. The end-tidal concentration of halothane may fall more quickly than that of sevoflurane [26], and halothane compared with sevoflurane may thus lead to a quicker awakening [26]. The application of continuous positive airway pressure (CPAP) and positive end-expiratory pressure (PEEP) when assisting ventilation with bag and mask may help relieve any obstruction by acting as a pneumatic splint.…”

Section: Inhalational Inductionmentioning

confidence: 99%

Progress in management of the obstructed airway

Patel

Pearce

2011

Anaesthesia

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SummaryThere is no consensus as to the ideal approach for the anaesthetic management of the adult obstructed airway and there are advocates of awake fibreoptic intubation, inhalational induction and intravenous induction techniques. This review considers the different options available for obstruction at different anatomical levels. Decisions must also be made on the urgency of the required intervention. Particular controversies revolve around the role of inhalational vs intravenous induction of anaesthesia, the use or avoidance of neuromuscular blockade and the employment of cannula cricothyroidotomy vs surgical tracheostomy.

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Effects of Disease on Drug Disposition and Pharmacokinetics

2022

Drug Disposition and Pharmacokinetics

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End-tidal Sevoflurane and Halothane Concentrations during Simulated Airway Occlusion in Healthy Humans

Cited by 5 publications

References 21 publications

Anaesthetic management of acute airway obstruction

Anaesthetic management of acute airway obstruction

Progress in management of the obstructed airway

Effects of Disease on Drug Disposition and Pharmacokinetics

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