Endobronchial Optical Coherence Tomography for Low-Risk Microscopic Assessment and Diagnosis of Idiopathic Pulmonary Fibrosis <i>In Vivo</i>

Hariri, Lida P.; Adams, David C.; Wain, John C.; Lanuti, Michael; Muniappan, Ashok; Sharma, Amita; Colby, Thomas V.; Mino‐Kenudson, Mari; Mark, Eugene J.; Kradin, Richard L.; Goulart, Hannah; Tager, Andrew M.; Suter, Melissa J.

doi:10.1164/rccm.201707-1446le

Cited by 47 publications

(27 citation statements)

References 12 publications

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“…A 56-year-old man presented to a pulmonologist with a 4-month history of dyspnea. 20 Chest high-resolution computed tomography showed traction bronchiectasis and bibasilar, subpleural reticular opacities consistent with interstitial lung disease. However, the lack of honeycombing precluded a more specific diagnosis by high-resolution computed tomography.…”

Section: Clinical Example 3: Ivm-oct Of Peripheral Lung: Usual Intersmentioning

confidence: 97%

In Vivo and Ex Vivo Microscopy: Moving Toward the Integration of Optical Imaging Technologies Into Pathology Practice

Wells

Thrall

Sorokina

et al. 2018

Archives of Pathology &Amp; Laboratory Medicine

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The traditional surgical pathology assessment requires tissue to be removed from the patient, then processed, sectioned, stained, and interpreted by a pathologist using a light microscope. Today, an array of alternate optical imaging technologies allow tissue to be viewed at high resolution, in real time, without the need for processing, fixation, freezing, or staining. Optical imaging can be done in living patients without tissue removal, termed in vivo microscopy, or also in freshly excised tissue, termed ex vivo microscopy. Both in vivo and ex vivo microscopy have tremendous potential for clinical impact in a wide variety of applications. However, in order for these technologies to enter mainstream clinical care, an expert will be required to assess and interpret the imaging data. The optical images generated from these imaging techniques are often similar to the light microscopic images that pathologists already have expertise in interpreting. Other clinical specialists do not have this same expertise in microscopy, therefore, pathologists are a logical choice to step into the developing role of microscopic imaging expert. Here, we review the emerging technologies of in vivo and ex vivo microscopy in terms of the technical aspects and potential clinical applications. We also discuss why pathologists are essential to the successful clinical adoption of such technologies and the educational resources available to help them step into this emerging role.

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Section: Clinical Example 3: Ivm-oct Of Peripheral Lung: Usual Intersmentioning

confidence: 97%

In Vivo and Ex Vivo Microscopy: Moving Toward the Integration of Optical Imaging Technologies Into Pathology Practice

Wells

Thrall

Sorokina

et al. 2018

Archives of Pathology &Amp; Laboratory Medicine

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“…In the near future, integration of new endoscopic guidance tools for the cryoprobe may be helpful to target the best biopsy areas with greater precision, potentially further increasing the diagnostic yield and reducing the complication rate of the technique. [46][47][48] Several studies have evaluated the diagnostic utility of cryobiopsy in the setting of the multidisciplinary diagnosis of diffuse lung disease 17,24,27,29,37,40,41 and it has been found it to be either similar to 49,50 or greater than 17,33,36,51 the histologic diagnostic yield alone. In a meta-analysis of 731 patients the pooled estimate of diagnostic yield for histologic interpretation of cryobiopsy alone was greater than the pooled estimate of multidisciplinary diagnosis of cryobiopsy (83% [95% CI, 73-94] versus 79% [95% CI, 65-93], respectively) 38 .…”

Section: Diagnostic Yield In Ildmentioning

confidence: 99%

Transbronchial Cryobiopsy in the Diagnosis of Fibrotic Interstitial Lung Disease

Mehrad

Colby

Rossi

et al. 2020

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Transbronchial cryobiopsy is an emerging procedure to obtain lung tissue for diagnosis of interstitial lung disease and has gained popularity because it is less invasive and has a lower rate of complications compared with nonselective surgical lung biopsy. Objective.— To provide an overview of the status of the medical literature regarding transbronchial cryobiopsy . Data Sources.— A literature search was performed using PubMed search engine. The terms “cryobiopsy” or “cryoprobe” and “interstitial lung disease” or “diffuse parenchymal lung disease” or “pulmonary fibrosis” were used, with the search concluding at the end of November 2019. Conclusions.— While the diagnostic yield of transbronchial cryobiopsy is slightly lower than surgical lung biopsy, a growing literature suggests that with a multidisciplinary approach cryobiopsy provides diagnostic and prognostic information approaching that of surgical lung biopsy with lower morbidity and mortality.

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“…Cultured cells or secretomas obtained by these cells may propel a personalized therapeutic approach [27,28]. This approach could be of utmost interest for IPF being in this disorder alveolar stem cell exhaustion one of the main pathogenetic events [29] (4) The combination of TBC procedure with navigation systems used already in bronchoscopy, or through cone-beam CT or the adoption of ancillary endoscopic tools to investigate the lung parenchyma such as confocal laser endomicroscopy or optical coherence tomography will allow sampling of specific areas with a higher degree of precision [30]. (5) Adoption of new technical tools (smaller probes, different cryogens, new modalities to insert bronchial blockers, robotic endoscopy, etc.)…”

Section: Scenario In the Next 5 Yearsmentioning

confidence: 99%

How might transbronchial cryobiopsy improve diagnosis and treatment of diffuse parenchymal lung disease patients?

Poletti

Ravaglia

Dubini

et al. 2017

Expert Review of Respiratory Medicine

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Endobronchial Optical Coherence Tomography for Low-Risk Microscopic Assessment and Diagnosis of Idiopathic Pulmonary Fibrosis In Vivo

Cited by 47 publications

References 12 publications

In Vivo and Ex Vivo Microscopy: Moving Toward the Integration of Optical Imaging Technologies Into Pathology Practice

In Vivo and Ex Vivo Microscopy: Moving Toward the Integration of Optical Imaging Technologies Into Pathology Practice

Transbronchial Cryobiopsy in the Diagnosis of Fibrotic Interstitial Lung Disease

How might transbronchial cryobiopsy improve diagnosis and treatment of diffuse parenchymal lung disease patients?

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