Endocannabinoid signaling in liver pathologies

Humar, Bostjan; Semmo, Nasser

doi:10.1002/9781118663387.ch17

Cited by 2 publications

(2 citation statements)

References 90 publications

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“…1 Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the MS and is thought to underlie its hallmark insulin resistance and its associated cardiovascular risks. 2 Surgical removal remains the only curative option for liver tumors with an increased risk of liver failure in the presence of hepatic steatosis. 3 To prevent blood loss during liver resection, portal inflow is temporarily occluded, leading to an ischemic period that may cause significant liver injury upon reperfusion.…”

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confidence: 99%

Omega-3 Fatty Acids Protect Fatty and Lean Mouse Livers After Major Hepatectomy

et al. 2017

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Objective: The aim of this study was to assess the effect of V3 fatty acids (V3FA) on fatty and lean liver in hepatic surgery. Background: The global spread of energy-dense diets has led to an endemic rise in fatty liver disease and obesity. Besides metabolic pathologies, steatosis enhances hepatic sensitivity to ischemia reperfusion (I/R) and impedes liver regeneration (LR). Steatosis limits the application of liver surgery, still the main curative option for liver cancer. V3FA are known to reverse steatosis, but how these lipids affect key factors defining surgical outcomes-that is, I/R, LR, and liver malignancy-is less clear. Methods: We established a standardized mouse model of high fat diet (HFD)-induced steatosis followed by V3FA treatment and the subsequent assessment of V3FA effects on I/R, LR, and liver malignancy (n ¼ 5/group), the latter through a syngeneic metastasis approach. Fatty liver outcomes were compared with lean liver to assess steatosis-independent effects. Nonparametric statistics were applied. Results: V3FA reversed HFD-induced steatosis and markedly protected against I/R, improved LR, and prolonged survival of tumor-laden mice. Remarkably, these beneficial effects were also observed in lean liver, albeit at a smaller scale. Notably, mice with metastases in fatty versus lean livers were associated with improved survival. Conclusions: V3FA revealed multiple beneficial effects in fatty and lean livers in mice. The improvements in I/R injury, regenerative capacity, and oncological outcomes await confirmatory studies in humans.

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Omega-3 Fatty Acids Protect Fatty and Lean Mouse Livers After Major Hepatectomy

et al. 2017

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“…[31][32][33] Fatty liver is considered a key pathology behind the development of insulin resistance. 34 Moreover, steatosis is an independent risk factor for liver cancer, 35 with obese subjects having a close to 5-fold likelihood to die of hepatocellular carcinoma (HCC). The only accepted treatment for NAFLD is calorie restriction and physical activity.…”

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Exercise Improves Outcomes of Surgery on Fatty Liver in Mice

et al. 2020

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Exercise efficiently counteracts the metabolic, ischemic, and regenerative deficits of fatty liver. AICAR acts as an exercise mimetic in settings of fatty liver disease, an important finding given the compliance issues associated with exercise. Exercising, or its substitution through AICAR, may provide a feasible strategy to negate the hepatic consequences of energy-rich diet, and has the potential to extend the application of liver surgery if confirmed in humans.

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Endocannabinoid signaling in liver pathologies

Cited by 2 publications

References 90 publications

Omega-3 Fatty Acids Protect Fatty and Lean Mouse Livers After Major Hepatectomy

Omega-3 Fatty Acids Protect Fatty and Lean Mouse Livers After Major Hepatectomy

Exercise Improves Outcomes of Surgery on Fatty Liver in Mice

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