2021
DOI: 10.3389/fendo.2021.699951
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Endocannabinoid System in Pregnancy Maintenance and Labor: A Mini-Review

Abstract: The endocannabinoid system (ECS) is a cell-signaling system present in multiple organ systems and is an integral part of sustaining the microenvironment necessary for early pregnancy success and maintenance. It plays a significant role in embryo development, transport and implantation as well as placentation. The current theory behind the initiation of term labor is that it is a complex, multifactorial process involving sex steroid hormones, prostaglandin production and interplay at the maternal-fetal interfac… Show more

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Cited by 20 publications
(18 citation statements)
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References 70 publications
(108 reference statements)
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“…The 2019 SAMHSA survey reported 5.4% of all pregnant women using marijuana and 1.7% of all pregnant women using marijuana daily or almost daily in the USA,131 increasing to over 8% with screening 132. The cannabinoid system is prevalent throughout the human body, with receptors in maternal, placental and fetal tissues 133. Cannabinoids affect both maternal and fetal physiology, cross the placenta and have been associated with preterm delivery, lower birth weight, and other adverse outcomes 134.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…The 2019 SAMHSA survey reported 5.4% of all pregnant women using marijuana and 1.7% of all pregnant women using marijuana daily or almost daily in the USA,131 increasing to over 8% with screening 132. The cannabinoid system is prevalent throughout the human body, with receptors in maternal, placental and fetal tissues 133. Cannabinoids affect both maternal and fetal physiology, cross the placenta and have been associated with preterm delivery, lower birth weight, and other adverse outcomes 134.…”
Section: Methodsmentioning
confidence: 99%
“…132 The cannabinoid system is prevalent throughout the human body, with receptors in maternal, placental and fetal tissues. 133 Cannabinoids affect both maternal and fetal physiology, cross the placenta and have been associated with preterm delivery, lower birth weight, and other adverse outcomes. 134 Thus, the anesthesiologist must be familiar with the physiologic effects and interactions to understand the usage and safety concerns of cannabinoids during pregnancy and the puerperium.…”
Section: Original Researchmentioning
confidence: 99%
“…ECS is active in virtually all cells of our organism. It plays an important role in the reproduction, function, and proper development of gametes [ 7 ], fertilization event, embryo implantation, and proper placenta development [ 8 ]. It is also active at all stages of embryogenesis, regulating cell division, and tissue and organ development, specifically, regulating differentiation of neural progenitors, synaptogenesis, and axonal migration [ 9 ].…”
Section: Role Of Endocannabinoids In the Human Bodymentioning
confidence: 99%
“…The endocannabinoid system is involved in different stages of reproduction and for early pregnancy and maintenance 17 . Thus an imbalance secondary to the use of cannabis at key moments is likely to induce deleterious effects.…”
Section: Discussionmentioning
confidence: 99%