Endocarditis caused by Corynebacterium group D2

Bacteremia Caused by Multiply Resistant Corynebacterium urealyticum: Six Case Reports and Review

“…or enterobacteria in routine blood cultures. Prior treatment with antibiotics, a characteristic described in previous reports [3,4,8] and relevant in four of our six patients, may predispose patients to colonization and subsequent infection by multiply resistant Corynebacterium urealyticum.…”

“…Multiresistance is common among Corynebacterium urealyticum isolates, a characteristic that may help identify this bacterium. All isolates in our series were resistant to imipenem, a finding that contradicts those of Ena et al [8], who reported a case in which the causative isolate was susceptible to this agent. Isolates were also resistant to quinolones, which is at variance with the first studies published [2,3], in which susceptibility to norfloxacin was reported, and which coincides with the description of the subsequent development of resistance to quinolones [4,5,[10][11][12].…”

“…Since then, only a few cases have been recorded, most of which were associated with concomitant infection of the urinary tract. Only eight cases of Corynebacterium urealyticum bacteremia without associated urinary tract infection have been reported [5,[7][8][9][10][11] (Table 2). Four of our patients who had bacteremia without urinary infection (Table 1) and the eight previously described patients (summarized in Table 2) were immunocompromised [5,[7][8][9][10][11].…”

“…Only eight cases of Corynebacterium urealyticum bacteremia without associated urinary tract infection have been reported [5,[7][8][9][10][11] (Table 2). Four of our patients who had bacteremia without urinary infection (Table 1) and the eight previously described patients (summarized in Table 2) were immunocompromised [5,[7][8][9][10][11]. Indeed, Corynebacterium urealyticum is considered an emerging pathogen in this type of patient and a major cause of morbidity and death in neoplastic patients [5,9,10].…”

“…The stability and diversity of colonizing strains have been extensively investigated in hospitalized patients [2][3][4][5][6][7][8] but not in healthy individuals. We therefore recruited four healthy individuals and determined the genotypes and resistotypes of Staphylococcus epidermidis strains that were found on a distinct skin area over a 1-year period and on other skin areas on a randomly selected day.…”