Endocrine Abnormalities Associated With Chronic Renal Failure

Salivary testosterone for the diagnosis of androgen deficiency in end-stage renal disease

“…When focusing on the number of years on dialysis, a negative correlation was found with testosterone levels. Disorders of the pituitary-gonadal axis rarely normalize with dialysis; in fact, they often progress [7,39]. Since there is evidence that testosterone is not substantially cleared from circulation during haemodialysis [21,34], hypogonadism in these patients seem to depend on reduced production of this hormone by the testes.…”

“…None of these signs and symptoms are specific of low androgen concentration but may raise suspicion [6]. Changes in prolactin, gonadotrophins and gonadal hormone levels are found in HD patients [7,8]; these alterations along with vascular, neurologic, psychogenic and other factors, such as medications, contribute to the development of sexual dysfunction [9].…”

Insuficiencia renal crónica avanzada y embarazo: presentación de 3 casos

“…Después del alumbramiento presentó E s rara la ocurrencia de embarazo en pacientes con insuficiencia renal crónica (IRC) avanzada (1,2). Posiblemente esto se debe a que el patrón hormonal en mujeres urémicas es de tipo anovulatorio, aún en aquéllas con menstruaciones regulares (70;0) ya que los niveles plasmáticos de progesterona son generalmente muy bajos y los de prolactina elevados (1)(2)(3)(4)(5). En la literatura médica abundan los reportes de embarazos en mujeres con IRC leve o moderada (creatinina sérica [Cr] ~ 3 Paciente con HT A diagnosticada en 1987 al presentar cuadro clínico interpretado como emergencia hipertensiva y controlada desde esa época por personal del hospital local, con furosemida, hidralazina, prazosín y dieta hiposódica.…”