Endocrine Abnormalities in Patients with Chronic Kidney Disease

Kuczera, Piotr; Adamczak, Marcin; Wiȩcek, Andrzej

doi:10.1515/prilozi-2015-0059

Cited by 24 publications

(45 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the kidney, uric acid is known to induce renal renin expression, enhance the activation of RAAS system, and initiate renal afferent arteriolar sclerosis, glomerular hypertrophy, and atherosclerosis [ 44 , 45 ]. Renal dysfunction was shown to cause hypothalamic pituitary gonadal axis dysfunction and to decrease testosterone secretion [ 46 ]. Decreased testosterone levels can weaken normal sexual initiation and sexual activity [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Sex Hormone and Blood Uric Acid in Male Patients with Type 2 Diabetes

Cao

Ruan

et al. 2017

International Journal of Endocrinology

View full text Add to dashboard Cite

The association between serum uric acid (SUA) level and sexual dysfunction in patients with diabetes is not well characterized. Type 2 diabetes mellitus (T2DM) causes metabolic disorders, including abnormal serum uric acid (SUA) levels. In this study, we enrolled 205 male patients with T2DM and investigated the relationship between sex hormone levels and SUA. Patients were divided into four groups based on SUA quartiles. On the other hand, based on the total testosterone (TT) level, patients were divided into three groups; SUA and other laboratory indices were determined. Increase in SUA level was significantly associated with decreased levels of TT, luteinizing hormone, follicle-stimulating hormone, sex hormone-binding globulin, and increased levels of dehydroepiandrosterone, age, body mass index (BMI), waist circumference, glycated hemoglobin, serum creatinine, and HOMA-IR levels. SUA, waist circumference, BMI, and HOMA-IR showed a negative correlation with TT level, while age showed a positive correlation with TT level. SUA and body mass index were found to be risk factors for gonadal dysfunction. Therefore, we conclude that hypogonadism of male patients with T2DM is related to SUA level.

show abstract

Section: Discussionmentioning

confidence: 99%

Association between Sex Hormone and Blood Uric Acid in Male Patients with Type 2 Diabetes

Cao

Ruan

et al. 2017

International Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…In women with chronic renal failure, hypothalamic-pituitary-gonadal axis disorders can be seen, which can be resulted in anovulatory menstrual cycles and thus infertility (27).…”

Section: Discussionmentioning

confidence: 99%

Incidence of Metabolic Syndrome and Long-Term Chronic Health Problems in Infertile Women

Kutlu¹,

Özberk²,

Görkemli³

2017

Istanbul Med J

View full text Add to dashboard Cite

Infertility is the inability to conceive for at least 1 year despite regular unprotected sexual intercourse. Approximately 10%-15% of couples worldwide have infertility problems. Primary infertility is defined as not being pregnant previously, and secondary infertility is defined as having trouble conceiving again despite unprotected intercourse, even though pregnancy has been previously achieved (1).In developed countries, the diseases causing infertility have been attributed to women at a rate of 37%, men at a rate of 8%, and both partners at a rate of 35%. The cause of infertility has not been found in 5% of couples (unexplained infertility). The most common causes of infertility are ovulatory disorders (25%), pelvic adhesions (12%), tubal occlusion (11%), other tubal anomalies (11%), hyperprolactinemia (7%), and endometriosis (15%). A cause has not been found in 20% of cases (2).Before initiating infertility treatment, the patient should be evaluated in terms of obesity. It has been observed that obesity can lead to many problems including chronic oligo-anovulation, menstrual irregularity, subfertility, increased risk of miscarriage, and negative pregnancy results. It has been demonstrated that obesity-related infertility or decreased fertility results from the effects of impaired hypothalamic-pituitary-ovarian axis seen in each step from the selection of the ovarian follicle to implantation (3).Metabolic syndrome (MetS) is defined as the presence of three or more criteria among abdominal obesity, hypertension (HT), hyperglycemia, increased triglyceride (TG) level, and decreased highdensity lipoprotein (HDL) cholesterol level. These components used for the diagnosis of MetS are also very important for the risk of the development of cardiovascular disease (CVD) and type II diabetes mellitus (DM) (4).The present study was performed to evaluate the frequency of MetS and related long-term chronic health problems (such as DM, thyroid dysfunction, HT, hyperlipidemia, and anemia) in infertile Incidence of Metabolic Syndrome and Long-Term Chronic Health Problems in Infertile WomenIntroduction: Infertility is a condition wherein there is no pregnancy within 1 year despite regular sexual intercourse without birth control. The aim of this study was to evaluate the incidence of metabolic syndrome (MetS) and chronic long-term health problems in infertile female patients. Methods:This cross-sectional and analytical study was retrospectively conducted on 701 women who applied to family medicine outpatient clinic and received a medical report with the complaint of female infertility. The weight, height, waist circumference, blood pressure, and laboratory results of subjects were recorded from the information in the files. MetS was diagnosed according to the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III) guideline. Results:The mean age of the 701 infertile women in the study was 29.9±4.4 (20-42) years; 81.6% (n=572) were housewives and 56.8% (n=398) completed primary school and were undergr...

show abstract

“…Chronic kidney disease results in dysfunction of the hypothalamic-pituitary-gonadal axis both in males and females. The severity of the endocrine and reproductive dysfunction seems to be proportional to the degree of kidney impairment [ 9 ]. Renal transplant recipients are patients who most frequently suffered from uremia for many years before transplantation.…”

Section: Renal Transplant Recipientsmentioning

confidence: 99%

“…Among men, disorders in the hypothalamic-pituitary-gonadal axis are usually reflected in erectile dysfunction, lowered libido, improper spermato- and steroidogenesis, most of which result from hypotestosteronemia [ 12 ]. It is believed that a lowered concentration of circulating sex steroidal hormones does not only result in clinical hypogonadism but may be additionally associated with a higher risk of premature cardiovascular disease development and graft loss as it plays a significant role in pathogenesis and the progression of kidney failure [ 9 , 13 , 14 ].…”

Section: Renal Transplant Recipientsmentioning

confidence: 99%

Hormonal (Im)Balance and Reproductive System’s Disorders in Transplant Recipients—A Review

Szypulska-Koziarska

Misiakiewicz-Has

Wiszniewska

2021

Biology

View full text Add to dashboard Cite

The rising need for treatment of end stage of organ failure results in an increased number of graft recipients yearly. The most commonly transplanted organs are kidney, heart, liver, bone marrow, lung and skin. The procedure of transplantation saves and prolongs the lives of chronically ill patients or at least improves the quality. However, following transplantation recipients must take immunosuppressive drugs on a daily basis. Usually, the immunosuppressive therapy comprises two or three drugs from different groups, as the mechanism of their action varies. Although the benefits of intake of immunosuppressants is undeniable, numerous side effects are associated with them. To different extents, they are neurotoxic, nephrotoxic and may influence the function of the reproductive system. Nowadays, when infertility is an urgent problem even among healthy pairs, transplant recipients face the problem of disturbance in the hypothalamic−pituitary axis. This review will provide an overview of the most common disturbances among the concentration of sex-related hormones in recipients of both sexes at different ages, including sexually immature children, adults of reproductive age as well as elderly women and men. We have also focused on the numerous side effects of immunosuppressive therapy regarding function and morphology of reproductive organs both in males and females. The current review also presents the regimen of immunosuppressive therapy and time since transplantation.

show abstract

Endocrine Abnormalities in Patients with Chronic Kidney Disease

Cited by 24 publications

References 25 publications

Association between Sex Hormone and Blood Uric Acid in Male Patients with Type 2 Diabetes

Association between Sex Hormone and Blood Uric Acid in Male Patients with Type 2 Diabetes

Incidence of Metabolic Syndrome and Long-Term Chronic Health Problems in Infertile Women

Hormonal (Im)Balance and Reproductive System’s Disorders in Transplant Recipients—A Review

Contact Info

Product

Resources

About