Endocrine Aspects of Prostate Cancer

Cloning of a novel receptor expressed in rat prostate and ovary.

“…4), whereas primordial follicles, oocytes, and corpora lutea appeared completely negative. Low (7,26,27 (Fig. 5).…”

“…Prostate was selected as an organ of interest given the high incidence of prostate cancer and benign prostatic hyperplasia. Initially prostate tumors are dependent on androgens for their maintenance and growth, but eventually nearly all tumors become independent of androgens and are thus beyond clinical control (7). The possibility exists that apart from androgens other (steroid) hormones or locally produced factors, interacting with nuclear receptors, are involved in cell proliferation, differentiation, and apoptosis of the normal prostate.…”

Controversies in the management of advanced prostate cancer

“…Surgical castration is a relatively simple, safe and inexpensive operation which can be performed under local or light general anaesthesia (Geller et al, 1988;Griffiths et al 1993). Although the convenience of a 'one-off' procedure, as opposed to medical therapy, means patient compliance is not a problem, surgical castration is not acceptable to all patients (Catalona, 1994), mainly because of psychological trauma (Cassileth et al, 1992;Denis, 1993;Fossa et al, 1994).…”