Endocrine disrupters – potential modulators of the immune system and allergic response

Chałubiński, Maciej; Kowalski, Marek L.

doi:10.1111/j.1398-9995.2006.01135.x

Cited by 150 publications

(111 citation statements)

References 104 publications

(93 reference statements)

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“…Nofer Institute of Occupational Medicine, Łódź, Poland IJOMEH 2011;24(2) 116 mediators as well as their impact on immune cell activation and survival has recently been presented by Chalubinski and Kowalski [20]. Phthalates have also been suggested to act as either allergens or adjuvants [21,22] and cause allergy and asthma [23,24].…”

Section: Introductionmentioning

confidence: 99%

Exposure to phthalates: Reproductive outcome and children health. A review of epidemiological studies

Jurewicz

Hanke

2011

International Journal of Occupational Medicine and Environmental Health

259

139

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Phthalates are a family of industrial chemicals that have been used for a variety of purposes. As the potential consequences of human exposure to phthalates have raised concerns in the general population, they have been studied in susceptible subjects such as pregnant women, infants and children. This article aims at evaluating the impact of exposure to phthalates on reproductive outcomes and children health by reviewing most recent published literature. Epidemiological studies focusing on exposure to phthalates and pregnancy outcome, genital development, semen quality, precocious puberty, thyroid function, respiratory symptoms and neurodevelopment in children for the last ten years were identified by a search of the PubMed, Medline, Ebsco, Agricola and Toxnet literature bases. The results from the presented studies suggest that there are strong and rather consistent indications that phthalates increase the risk of allergy and asthma and have an adverse impact on children's neurodevelopment reflected by quality of alertness among girls, decreased (less masculine) composite score in boys and attention deficit hyperactivity disorder. Results of few studies demonstrate negative associations between phthalate levels commonly experienced by the public and impaired sperm quality (concentration, morphology, motility). Phthalates negatively impact also on gestational age and head circumference; however, the results of the studies were not consistent. In all the reviewed studies, exposure to phthalates adversely affected the level of reproductive hormones (luteinizing hormone, free testosterone, sex hormone-binding globulin), anogenital distance and thyroid function. The urinary le vels of phthalates were significantly higher in the pubertal gynecomastia group, in serum in girls with premature thelarche and in girls with precocious puberty. Epidemiological studies, in spite of their limitations, suggest that phthalates may affect reproductive outcome and children health. Considering the suggested health effects, more epidemiologic data is urgently needed and, in the meantime, precautionary policies must be implemented.

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Section: Introductionmentioning

confidence: 99%

Exposure to phthalates: Reproductive outcome and children health. A review of epidemiological studies

Jurewicz

Hanke

2011

International Journal of Occupational Medicine and Environmental Health

259

139

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“…Az ED-k befolyásolják a citokin-és immunglobulin-szintézist, valamint az immunsejtek aktivitását és túlélését, továbbá közreműködnek az autoimmun betegségek kialakulásában [54]. Növelik az allergiás jelenségek (példá-ÖSSZEFOGLALÓ KÖZLEMÉNY ul asztma) előfordulását is.…”

Section: Az Immunrendszerunclassified

A hormonális rendszer válsága: az endokrin diszruptorok egészségügyi hatásai

Csaba

2017

Orvosi Hetilap

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Az endokrin diszruptorok a környezetből az állati (emberi) szervezetbe jutó olyan természetes vagy mesterséges molekulák, amelyek hormonreceptorokhoz kapcsolódva serkentik vagy gátolják adott sejtek tevékenységét, hormonok vagy receptorok előállítását, illetve transzportját. Ha kapcsolódásuk valamely kritikus periódusban történik, hibás hormonális imprintinget hoznak létre életre szóló következményekkel, mint hormonbefolyásolt sejtműködések megváltozása, betegségekre való hajlam manifesztálódása vagy betegségek megjelenése, ezért orvosi-egészségügyi jelentőségük van. Az endokrin diszruptorok száma nagy és éppúgy, mint felhasználásra kerülő mennyiségük, növekszik, ezáltal számos, felnőttkorban megjelenő kórkép (például daganat) visszavezethető perinatalis kori endokrin diszruptorártalmakra. Tartós hatásuk alapvető emberi jellegzetességek (például menarche időpontja) megváltozásához vezet. Az A-és D-vitamin is hormon (exohormon) és kívülről bejutva a szervezetbe endokrin diszruptorok lehetnek. Az endokrin diszruptorok által kiváltott imprinting az utódgenerációkra epigenetikusan átadódik, így befolyásolhatja az utódok gyógyszerérzékenységét is. Ha az epigenetikus öröklődés tartóssá válik, annak humánevolúciós jelentősége is lehet.

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“…One possibility suggested in the paper by Choi et al (2010b) is that PGEs may act as endocrine disruptors, and in turn affect immune or allergic response through such a mechanism. However, currently there is little or no evidence available to implicate PGEs as endocrine disruptors, and the link between endocrine disruption and immune perturbation remains speculative (Chalubinski and Kowalski, 2006).…”

Section: A Case In Point: Propylene Glycol and The Glycol Ethersmentioning

confidence: 99%