Endocrine effects of tetrabromobisphenol-A (TBBPA) in Wistar rats as tested in a one-generation reproduction study and a subacute toxicity study

Effects of neonatal exposure to the flame retardant tetrabromobisphenol-A, aluminum diethylphosphinate or zinc stannate on long-term potentiation and synaptic protein levels in mice

“…Accordingly, using the same dosing paradigm, possible (developmental) neurotoxic effects of TBBPA, Alpi and ZS can be compared with existing (developmental) neurotoxicity data of BFRs. While we did not observe developmental neurotoxicity following a single oral TBBPA exposure, chronic exposure (which appears more realistic for the human situation) may affect, e.g., auditory neuron function as a consequence of disturbance of thyroid hormones ; Van der Ven et al 2008). Nonetheless, the present single dose study suggests a low concern for the developing brain following exposure to TBBPA, Alpi or ZS.…”

“…The uncertainty whether or not TBBPA induces developmental neurotoxicity is further underlined by gestational/lactational exposure studies which indicate that developmental exposure of rats resulted in alterations of neuronal migration in the dentate gyrus (Saegusa et al 2012), while several critical neurochemical parameters were not affected (Saegusa et al 2009). Additionally, a one-generation reproduction study in rats showed that fear memory in adult rats is not affected, although effects on auditory neuron function were observed , and a comparable reproduction study indicated that thyroid hormones, which are also involved in neuronal development, are affected by TBBPA ( Van der Ven et al 2008). Although several endocrine effects were observed in rats following chronic exposure , it remains debatable whether the observed disturbances of (thyroid) hormones affect the developing brain to such a degree that (developmental) neurotoxicity occurs.…”

Silver ion post-column derivatization electrospray ionization mass spectrometry for determination of tetrabromobisphenol A derivatives in water samples

“…Although research from the Brominated Science and Environmental Forum (BSEF) and the European Brominated Flame Retardant Industry Panel (EBFRIP) asserted that TBBPA poses no risk to human health, 6,24,25 the endocrine effect and the immunotoxicity of TBBPA are continual concerns of toxicologists. 5,[26][27][28][29][30] More importantly, one of the derivatives (TBBPA-BAE) has been found to be a neurotoxin in the environment. 20 Throughout pyrolysis, combustion and degradation of TBBPA and its derivatives, the decomposition products might also lead to a health and environmental risk.…”

Actions of endocrine-disrupting chemicals on stem/progenitor cells during development and disease

“…TH-related effects included decreased circulating thyroxine (T 4 ) and increased TSH levels (van der Ven et al 2009). Although in utero exposure to the brominated FR tetrabromobisphenol-A exhibited similar effects in decreasing circulating T 4 levels, bone development was not disrupted ( Van der Ven et al 2008). These studies imply that the effects of FR exposure on bone development are gender-and flame-retardant specific.…”