Endocrinological disorders and inflammatory skin diseases during COVID-19 outbreak: a review of the literature

Marasca, Claudio; Fabbrocini, Gabriella; Barrea, Luigi; Capasso, Gianmarco; Guida, Adriana Di; Cinelli, Eleonora; Fontanella, Giuseppina

doi:10.23736/s0391-1977.20.03248-4

Cited by 9 publications

(5 citation statements)

References 64 publications

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“…[20,21] In a recent study, IL-6 and MCP-1 were identified as the factors that aggravate skin inflammatory diseases in certain environments. [22] In the present study, EEPK significantly prevented the production of TNF-α, IFN-γ, IL-6, and MCP-1 in the skin tissues of CD mice (Figure 5), and our results show that the antiinflammatory properties of EEPK can prevent basal cell layer destruction and histopathological abnormalities, such as epidermal hyperplasia, and immune cell infiltration by suppressing cytokine and chemokine production. Korean pine nuts contain several fatty acids, and its pinolenic acid (a major component) has known anti-inflammatory effects.…”

Section: Discussionsupporting

confidence: 73%

Therapeutic Effects of Pinus koraiensis on 1-Fluoro-2,4-Dinitrofluorobenzene-induced Contact Dermatitis in Mice

Kang

Son

et al. 2023

Pharmacognosy Magazine

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Background Korean pine nuts (Semen Pinus koraiensis ( P. koraiensis)) have been a valuable ingredient in Korean cuisine since ancient times, and the classical literature on traditional medicine states that pine nuts can moisturize skin. Aims To confirm the therapeutic efficacy of the ethanol extract of these pine nuts in an animal contact dermatitis (CD) model. Materials and Methods Korean pine nuts were extracted using 70% ethanol, and the crude extract obtained was condensed and lyophilized to produce EEPK (the 70% ethanol extract of P. koraiensis). A DNFB (1-fluoro-2,4-dinitrofluorobenzene)-induced BALB/c mouse model of CD was used to investigate the effects of EEPK on skin symptoms, histopathological abnormalities, and cytokine secretion in inflamed tissues. Results EEPK reduced skin color changes, lesion severities, and dorsal skin thickening and inhibited epidermis hyperplasia and immune cell infiltration into inflamed tissues. In addition, EEPK suppressed the productions of tumor necrosis factor-α, interferon-γ, interleukin-6, and monocyte chemoattractant protein-1 but did not affect body weights or spleen/body weight ratios. Conclusion P. koraiensis has potential as a therapeutic agent for CD and as a treatment for inflammatory skin disease management products. Furthermore, the mechanism underlying its therapeutic effects differs from that of corticosteroids.

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Section: Discussionsupporting

confidence: 73%

Therapeutic Effects of Pinus koraiensis on 1-Fluoro-2,4-Dinitrofluorobenzene-induced Contact Dermatitis in Mice

Kang

Son

et al. 2023

Pharmacognosy Magazine

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“…Beyond the physical aspect, HS also deeply impairs the quality of life from social interaction to the sexual quality of life, 2 which in turn could potentially increase binge eating, alcoholism and opioid abuse. [3][4][5] As there is no cure for HS and no effective intervention in many cases, disease treatment remains a challenge. The lack of robust biomarkers for disease activity presents a significant obstacle to developing new and effective HS treatment and monitoring strategies.…”

Section: Introductionmentioning

confidence: 99%

“…. Beyond the physical aspect, HS also deeply impairs the quality of life from social interaction to the sexual quality of life, 2 which in turn could potentially increase binge eating, alcoholism and opioid abuse 3–5 . As there is no cure for HS and no effective intervention in many cases, disease treatment remains a challenge.…”

Section: Introductionmentioning

confidence: 99%

Hidradenitis suppurativa associated telomere‐methylome dysregulations in blood

Radhakrishna,

Ratnamala,

Jhala

et al. 2023

Acad Dermatol Venereol

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BackgroundHidradenitis suppurativa (HS) is a chronic debilitating disease with a significant burden of both organic and psychological comorbidities. It has been shown that certain telomere‐related genes (TRGs) affect a wide range of diseases, including HS and its associated comorbidities, but their exact role in HS pathogenesis is still unknown.ObjectivesTo determine whether TRG methylomes can be used as biomarkers in HS.MethodsUsing the Illumina HumanMethylation450 BeadChip array, we examined methylation variations associated with TRGs in HS cases and age‐, sex‐, and ethnicity‐matched healthy controls. The study utilized integrated bioinformatics statistical methods, such as a false discovery rate (FDR), the area under the receiver operating characteristic curve (AUC), and principal component analysis.ResultsThere were a total of 585 different differentially methylated CpG sites identified in 585 TRGs associated with HS (474 hypomethylated and 111 hypermethylated) (FDR p‐value <0.05). A number of these CpGs have been identified as being involved in increased pain sensitivity including EPAS1, AHR, CSNK1D, DNMT1, IKBKAP, NOS3, PLCB1, and PRDM16 genes; GABRB3 as a potential alcohol addiction marker; DDB1, NSMCE2, and HNRNPA2B1 associated with cancers. Pathway analysis identified 67 statistically significant pathways, including DNA repair, telomere maintenance, mismatch repair, and cell cycle control. (p<0.001).ConclusionThe disruption of TRGs leads to the shortening of telomeres, which is associated with HS progression, aging, cellular senescence, and an increased risk of various diseases, including cancer and associated comorbidities, such as metabolic syndrome, cardiovascular disease, and inflammatory disorders. Further research is necessary to better understand the underlying mechanisms and establish causal links between TRGs and HS. The present study is the first effort to comprehend potential pathomechanisms of sporadic HS cases concentrating on PBMC methylome since ours.

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“…3 Hypertension, cardiovascular disease and diabetes are the most frequent comorbidities, while older age, male sex and obesity were identified as risk factors for susceptibility and severity of COVID-19. 3,4,[6][7][8][9][10][11][12][13][14][15][16][17][18][19] Clinical studies have repeatedly reported small numbers of patients with COPD among patients hospitalized due to COVID-19 with rates being as low as 2% to 10%. 3,4,20 In fact, chronic respiratory disease, that is considered to be a risk factor for respiratory infections, was not among the main risk factors for severe COVID-19.…”

Section: Text Introductionmentioning

confidence: 99%

Could inhaled corticosteroids be the game changers in the prevention of severe COVID-19? A review of current evidence

et al. 2022

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Endocrinological disorders and inflammatory skin diseases during COVID-19 outbreak: a review of the literature

Cited by 9 publications

References 64 publications

Therapeutic Effects of Pinus koraiensis on 1-Fluoro-2,4-Dinitrofluorobenzene-induced Contact Dermatitis in Mice

Therapeutic Effects of Pinus koraiensis on 1-Fluoro-2,4-Dinitrofluorobenzene-induced Contact Dermatitis in Mice

Hidradenitis suppurativa associated telomere‐methylome dysregulations in blood

Could inhaled corticosteroids be the game changers in the prevention of severe COVID-19? A review of current evidence

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