2024
DOI: 10.1101/2024.08.02.606287
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Endocytic dynamin deficiency impairs the host colonization of phytopathogenic fungi

Xin Chen,
Xiaomin Chen,
Yunfei Long
et al.

Abstract: During host-pathogen interactions, pathogens employ endolysosomal trafficking to fine-tune host and environmental cues, facilitating disease progression. Inhibiting the functions of the endolysosomal network could be promising for the control of plant fungal diseases. Herein, we showed that inhibition of the endocytic dynamin FgVps1 by the phenothiazines chlorpromazine (CPZ) and prochlorperazine (PCZ) leads to endolysosomal dysfunction. Further analyses revealed that the phenothiazines directly bind the GTPase… Show more

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