Endocytosis of abiotic nanomaterials and nanobiovectors: Inhibition of membrane trafficking

Makvandi, Pooyan; Chen, Mei‐Ling; Sartorius, Rossella; Zarrabi, Ali; Ashrafizadeh, Milad; Moghaddam, Farnaz Dabbagh; Ma, Jia; Mattoli, Virgilio; Tay, Franklin R.

doi:10.1016/j.nantod.2021.101279

Cited by 90 publications

(58 citation statements)

References 299 publications

(342 reference statements)

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“…PEG, a highly biocompatible and water-soluble polymer, was used for niosome surface modification. 41 , 43 The functionalization of niosomes with PEG can increase the passive targeting of anticancer therapeutics and enhance the internalization of drugs into cancer cells. 44 , 45 FA is one of the best active targeting ligands that bind to folate receptors with high affinity and internalize into cells through receptor-mediated endocytosis.…”

Section: Discussionmentioning

confidence: 99%

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pH-Responsive, Adorned Nanoniosomes for Codelivery of Cisplatin and Epirubicin: Synergistic Treatment of Breast Cancer

Moammeri

Abbaspour

Zafarian

et al. 2022

ACS Appl. Bio Mater.

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Combination chemotherapy has become a treatment modality for breast cancer. However, serious side effects and high cytotoxicity associated with this combination therapy make it a high-risk method for breast cancer treatment. This study evaluated the anticancer effect of decorated niosomal nanocarriers loaded with cisplatin (CIS) and epirubicin (EPI) in vitro (on SKBR3 and 4T1 breast cancer cells) and in vivo on BALB/c mice. For this purpose, polyethylene glycol (PEG) and folic acid (FA) were employed to prepare a functionalized niosomal system to improve endocytosis. FA-PEGylated niosomes exhibited desired encapsulation efficiencies of ∼91.2 and 71.9% for CIS and EPI, respectively. Moreover, cellular assays disclosed that a CIS and EPI-loaded niosome (NCE) and FA-PEGylated niosomal CIS and EPI (FPNCE) enhanced the apoptosis rate and cell migration in SKBR3 and 4T1 cells compared to CIS, EPI, and their combination (CIS+EPI). For FPNCE and NCE groups, the expression levels of Bax , Caspase3 , Caspase9 , and Mfn1 genes increased, whereas the expression of Bcl2 , Drp1 , MMP-2 , and MMP-9 genes was downregulated. Histopathology results showed a reduction in the mitosis index, invasion, and pleomorphism in BALB/c inbred mice with NCE and FPNCE treatment. In this paper, for the first time, we report a niosomal nanocarrier functionalized with PEG and FA for codelivery of CIS and EPI to treat breast cancer. The results demonstrated that the codelivery of CIS and EPI through FA-PEGylated niosomes holds great potential for breast cancer treatment.

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Section: Discussionmentioning

confidence: 99%

“… 44 , 45 FA is one of the best active targeting ligands that bind to folate receptors with high affinity and internalize into cells through receptor-mediated endocytosis. 41 , 46 Folate receptors are anchored cell surface receptors that are upregulated and overexpressed in numerous cancer cell types compared with normal cells. 47 …”

Section: Discussionmentioning

confidence: 99%

pH-Responsive, Adorned Nanoniosomes for Codelivery of Cisplatin and Epirubicin: Synergistic Treatment of Breast Cancer

Moammeri

Abbaspour

Zafarian

et al. 2022

ACS Appl. Bio Mater.

Self Cite

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“…Because our NPs were smaller than 500 nm and had an FA ligand attached to their surfaces, they could be internalized through receptor-mediated clathrin-enabled endocytosis [ 53 ]. This internalization mechanism is initiated after a specific ligand-encased nanomaterial binds to a receptor on the surface of the cell membrane.…”

Section: Discussionmentioning

confidence: 99%

Folate-Decorated Cross-Linked Cytochrome c Nanoparticles for Active Targeting of Non-Small Cell Lung Carcinoma (NSCLC)

et al. 2022

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The folate receptor alpha (FR), which is overexpressed in solid tumors including NSCLC, can be utilized for active tumor targeting to afford more effective cancer therapies. In this context, cytochrome c (Cyt c) has drawn attention to cancer research because it is non-toxic, yet, when delivered to the cytoplasm of cancer cells, can kill them by inducing apoptosis. Cyt c nanoparticles (NPs, 169 ± 9 nm) were obtained by solvent precipitation with acetonitrile, and stabilized by reversible homo-bifunctional crosslinking to accomplish a Cyt-c-based drug delivery system that combines stimulus-responsive release and active targeting. Cyt c was released under intracellular redox conditions, due to an S–S bond in the NPs linker, while NPs remained intact without any release under extracellular conditions. The NP surface was decorated with a hydrophilic folic acid–polyethylene glycol (FA–PEG) polymer for active targeting. The FA-decorated NPs specifically recognized and killed cancer cells (IC50 = 47.46 µg/mL) that overexpressed FR, but showed no toxicity against FR-negative cells. Confocal microscopy confirmed the preferential uptake and apoptosis induction of our NPs by FR-positive cancer cells. In vivo experiments using a Lewis lung carcinoma (LLC) mouse model showed visible NP accumulation within the tumor and inhibited the growth of LLC tumors.

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“…For materials to be delivered accurately and efficiently, several obstacles need to be overcome; the barriers are partly related to the means of administration, but there are some other common obstacles, including high interstitial pressure impeding the entry of particles into tissues; 88,89 elimination by the MPS or RES, in which endocytosis of materials may be categorized into phagocytosis, macropinocytosis, clathrinmediated endocytosis, caveolae-dependent endocytosis, and independent endocytosis; [90][91][92] lysosome degradation; 93 and the presence of nucleases in the case of DNA or RNA vaccines.…”

Section: Effects Of Physical Properties Of Delivery Systems On Their ...mentioning

confidence: 99%

Engineering optimal vaccination strategies: effects of physical properties of the delivery system on functions

2022

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Endocytosis of abiotic nanomaterials and nanobiovectors: Inhibition of membrane trafficking

Abstract: Graphical Abstract

Cited by 90 publications

References 299 publications

pH-Responsive, Adorned Nanoniosomes for Codelivery of Cisplatin and Epirubicin: Synergistic Treatment of Breast Cancer

pH-Responsive, Adorned Nanoniosomes for Codelivery of Cisplatin and Epirubicin: Synergistic Treatment of Breast Cancer

Folate-Decorated Cross-Linked Cytochrome c Nanoparticles for Active Targeting of Non-Small Cell Lung Carcinoma (NSCLC)

Engineering optimal vaccination strategies: effects of physical properties of the delivery system on functions

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