Endodermal sinus tumor of the ovary associated with pregnancy

Tératome immature de l’ovaire en cours de grossesse

“…À ce terme, le taux de malformations foetales graves associé à la réalisation d'une chimiothérapie ne semble pas en effet supérieur à celui observé dans la population générale (de l'ordre de 3 %) [13]. Plusieurs auteurs ont rapporté que des femmes enceintes, porteuses de tumeurs germinales malignes de l'ovaire, ont reçu une chimiothérapie durant la grossesse et ont donné naissance à des enfants normaux [14,15]. La littérature décrit de nombreuses utilisations de bléomycine et de cisplatine pendant la grossesse, sans effet indésirable sur le foetus.…”

Neoadjuvant chemotherapy followed by radical hysterectomy for invasive cervical cancer diagnosed during pregnancy: report of a case and review of the literature

“…The use of cisplatin both as a single agent and in combination during pregnancy is relatively poorly documented. In the literature, we could retrieve only 21 cases (12)(13)(14)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40) and only two cases with carboplatin exposure (29,41) . Apart from intrauterine growth restriction in 2/21 (9.5%) fetuses (28,32) , most children were appropriate for gestational age (19/21, 90.5%).…”

Chemotherapy for Gynecologic Cancers Occurring During Pregnancy

“…When indicated, adjuvant chemotherapy with bleomycin, etoposide, and cisplatin is recommended, which is also the recommended regimen for nonpregnant patients. 12,[26][27][28][29][30][31][32][33] Use of bleomycin, vinblastine, and cisplatin has not been associated with adverse maternal effects, although 1 patient was delivered at 31 weeks due to maternal pregnancyinduced hypertension. 26,31,32 Only one case has reported adverse fetal outcome including ventriculomegaly, cerebral atrophy, anemia, and neutropenia.…”

“…12,[26][27][28][29][30][31][32][33] Use of bleomycin, vinblastine, and cisplatin has not been associated with adverse maternal effects, although 1 patient was delivered at 31 weeks due to maternal pregnancyinduced hypertension. 26,31,32 Only one case has reported adverse fetal outcome including ventriculomegaly, cerebral atrophy, anemia, and neutropenia. 27 More recently, paclitaxel and carboplatin have been used to treat ovarian dysgerminoma during pregnancy, with no significant adverse effects to mother or fetus; the patient remained free of disease for the reported 22 months of follow-up period.…”