Endogenous aspergillus endophthalmitis

Weishaar, Paul D.; Flynn, Harry W.; Murray, Timothy G.; Davis, Janet L.; Barr, Charles C.; Gross, Jeffrey G.; Mein, Calvin E.; McLean, W. Copley; Killian, John H.

doi:10.1016/s0161-6420(98)71225-3

Cited by 147 publications

(29 citation statements)

References 28 publications

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“…Several studies have shown that patients may be asymptomatic if the lesion is in the peripheral retina or if the patient is moribund, and symptoms are not useful factors for assessing the presence of EFE in patients who are at risk [8,9]. Therefore, the patient in our study did not realize that he had an infection in his right eye until a thorough fundus examination showed susceptible clinical features.…”

Section: Discussionmentioning

confidence: 82%

The Disease Course of Bilateral Endogenous Fungal Endophthalmitis

Yuan¹,

Liang²,

Zhong³

2017

J Clin Exp Ophthalmol

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Purpose: To report the dynamic disease course of a case of bilateral endogenous fungal endophthalmitis, which was successfully treated.Case Report: A 54 year old Chinese man with a history of extracorporeal shock wave lithotripsy (ESWL) and ureteroscopy was referred to our center. After 1 week, his best corrected Snellen visual acuity (BCVA) values were 20/100 and 20/25; the interface between the posterior vitreous face and the retinal surface appeared to be rough in the right eye, and a similar, larger, low-rounded circumscribed apophysis could be observed in the left eye. During the 2 nd week, his BCVA values decreased to 20/400 and 20/32. He was diagnosed with bilateral endogenous Candida albicans endophthalmitis after a vitreous biopsy and then underwent binocular pars plana vitrectomy (PPV) with silicone oil injection in both eyes. Postoperatively, his BCVA values were 20/63 and 20/32, and fundoscopy and optical coherence tomography (OCT) showed a regular and smooth interface and retina surface after the removal of the silicone oil at 3 months. Conclusions:We concluded that the rough interface between the posterior vitreous face and the retinal surface is one of the early typical sign of endogenous fungal endophthalmitis, which was treated with PPV with silicone oil injection and antifungal reagents.

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Section: Discussionmentioning

confidence: 82%

The Disease Course of Bilateral Endogenous Fungal Endophthalmitis

Yuan¹,

Liang²,

Zhong³

2017

J Clin Exp Ophthalmol

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“…In general it is associated with a disseminated infection in immunocompromised patients, although it can be an isolated finding [35]. Aspergillus endophthalmitis has been reported following antibiotic administration [18], surgical procedures [5], in parenteral drug abusers [6,11,38] and in patients with malignancy (lymphoma and leukaemia) [14,28]. However, the main risk group are individuals who received immunosuppressive agents or transplant recipients [3,9,13,26].…”

Section: Discussionmentioning

confidence: 99%

“…Although the fundus changes are characterised by extensive chorioretinal damage with necrotised foci in central or temporal parts of the macula [9,38] and in the paramacular area close to the retinal vessels [4,10], a number of other conditions can produce a similar picture.…”

Section: Discussionmentioning

confidence: 99%

“…This antifungal drug is notorious for significant renal and hepatic toxicity and systemic side effects during administration, such as fever, chills, nausea, and vomiting. Impairment of renal function makes the intravenous treatment with amphotericin B particularly undesirable for immunocompromised patients [38].…”

Section: Discussionmentioning

confidence: 99%

“…Among new antifungal agents the triazole and echinocandin groups show excellent properties [17,20,38]. The echinocandins, especially the recently approved caspofungin, were not considered as an alternative for treatment due to their potential hepatic side effects in co-administration with cyclosporin A and their availability only in an intravenous formulation [37].…”

Section: Discussionmentioning

confidence: 99%

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Histological examination of an eye with endogenous Aspergillus endophthalmitis treated with oral voriconazole: a case report

Aliyeva¹,

Ullmann

Kottler³

et al. 2004

Graefe's Arch Clin Exp Ophthalmol

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Endogenous Aspergillus endophthalmitis is a devastating condition often associated with immunodeficiency. The pathogenesis of this entity implies the primary invasion of choroidal and retinal vessels. The lack of antifungal drugs with high blood-ocular permeability results in an extremely poor visual prognosis. Our histological examination indicates promising activity and ocular penetration of the new antifungal agent voriconazole.

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