Endogenous digoxin-like immunoactivity and diabetes mellitus: facts and hypotheses

Martinka, Emil; Galajada, P.; Ochodnický, M; Lichardus, B; Straka, Shana R.; Mokáň, Marián

doi:10.1016/s0306-9877(97)90212-7

Cited by 10 publications

(7 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Endogenous digitalis-like Na/K-ATPase (NKA) inhibitors, i.e., cardiotonic steroids (CTS), are implicated in the pathogenesis of NaCl-sensitve hypertension, diabetes mellitus (DM), and preeclampsia (PE) [1][2][3]. Clinical data indicate that impairment of glucose tolerance and DM both represent potential risk factors of PE [4,5].…”

Section: Introductionmentioning

confidence: 99%

Endogenous sodium pump inhibitors, diabetes mellitus and preeclampsia

et al. 2007

View full text Add to dashboard Cite

Endogenous inhibitors of the Na/K-ATPase (NKA) and diabetes mellitus (DM) are both risk factors for preeclampsia and NaCl sensitive hypertension. Our goal was to test the hypothesis that NaCl supplementation, induces preeclampsia-like symptoms in pregnant rats with DM via stimulation of marinobufagenin (MBG), a natriuretic and vasoconstrictor inhibitor of the NKA. Type 2 DM in female Sprague-Dawley rats was induced by administration of 65 mg/kg streptozotocin at day 4 post partum. In intact rats, pregnancy was associated with a 2-fold increase in MBG levels and a mild impairment in glucose tolerance. Pregnant rats with DM exhibited fetal macrosomia, greater impairment of glucose tolerance, and higher levels of MBG as compared to that in normal pregnant rats. As compared to intact pregnant rats, NaCl supplementation of diabetic pregnant rats (drinking 1.8% NaCl during days 12-19 of pregnancy) was associated with an increase in systolic blood pressure, decreased fetal and placental weight, five-fold elevation of MBG excretion, and 42% inhibition of NKA in erythrocytes. In nonpregnant rats, in vivo pretreatment with anti-MBG antibody produced an exaggerated response of plasma levels of glucose and insulin in oral glucose tolerance test. These results suggest that MBG is a common factor in the pathogenesis of DM and preeclampsia, and that regulation of glucose tolerance may be one of the physiological functions of endogenous cardiotonic steroids.

show abstract

Section: Introductionmentioning

confidence: 99%

Endogenous sodium pump inhibitors, diabetes mellitus and preeclampsia

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Experimental models using unilaterally nephrectomized dogs (Haddy and Pamnani, 1998) and volume overload in rats (Göó´z M., unpublished observation), as well as clinical studies suggest the importance of elevated endogenous OLF in essential and in some secondary hypertensions related to physiological and pathological volume expansion (Martinka et al, 1997;Vakkuri et al, 2000;Pierdomenico et al, 2001). Prolonged administration of ouabain in rats induced a reversible form of hypertension (Manunta et al, 2000), although the mechanisms underlying ouabain-induced hypertension are poorly-understood.…”

Section: Introductionmentioning

confidence: 98%

Endogenous ouabain-like factor (OLF) secretion is modulated by nicotinic mechanisms in rat adrenocortical cells

et al. 2004

View full text Add to dashboard Cite

“…In the previous studies, it was shown that the EDNF level is increased in patients with type 1 and type 2 diabetes mellitus [6][7][8]. It was hypothesized that the EDNF hyperproduction during diabetes mellitus is caused by the retention of fluid and sodium.…”

mentioning

confidence: 99%

“…It was hypothesized that the EDNF hyperproduction during diabetes mellitus is caused by the retention of fluid and sodium. It has been further hypothesized that the changes in EDNF are more pronounced in type 2 diabetes mellitus [8]. However, the nature of EDNF involved in the pathogenesis of diabetes mellitus is still unknown, and the data on the changes in the EDNF level in insulin-dependent and non-insulin-dependent diabetes mellitus are contradictory [8].…”

mentioning

confidence: 99%