Endogenous Ghrelin Levels and Perception of Hunger: A Systematic Review and Meta-Analysis

Anderson, Kara C.; Hasan, Faten; Grammer, Emily E.; Kranz, Sibylle

doi:10.1016/j.advnut.2023.07.011

Cited by 6 publications

(4 citation statements)

References 93 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, human studies regarding ghrelin´s impact on depressive symptoms have reported mixed results to date. Contrary to the association between levels of ghrelin and increased subjective hunger (Anderson et al, 2023), previous studies with patients suffering from MDD revealed that loss of appetite is associated with higher blood levels of ghrelin (Matsuo et al, 2012, Simmons et al, 2020, even after controlling for differences in BMI. Concerning depressed mood, some studies in patients with MDD have reported correlations between ghrelin levels and depressive symptoms (Algul andOzcelik, 2018, Akter et al, 2014), while other studies found that ghrelin infusions are associated with an improved depressed mood (Kluge et al, 2011).…”

Section: Introductioncontrasting

confidence: 60%

See 1 more Smart Citation

Ghrelin is associated with an elevated mood after an overnight fast in depression

Fahed,

Schulz,

Klaus

et al. 2023

Preprint

View full text Add to dashboard Cite

BackgroundMajor depressive disorder (MDD) comprises subtypes with distinct symptom profiles. For example, patients with melancholic and atypical MDD differ in the direction of appetite and body weight changes as well as mood reactivity. Despite reported links to altered energy metabolism, the role of circulating neuropeptides from the gut in modulating such symptoms remains largely elusive.MethodsWe collected data from 103 participants, including 51 patients with MDD and 52 healthy control participants (HCP). After an overnight fast, we measured blood levels of (acyl and des-acyl) ghrelin and participants reported their current metabolic and mood states using visual analog scales (VAS). Furthermore, they completed symptom-related questionnaires (i.e., STAI-T).ResultsPatients with atypical versus melancholic MDD reported less negative affect (p= .025). Higher levels of acyl ghrelin (corrected for BMI) were associated with improved mood (p= .012), specifically in patients with MDD. These associations of ghrelin were not mood-item specific and exceeded correlations with trait markers of negative affectivity. In contrast to associations with mood state, higher levels of ghrelin were not associated with increased hunger per se or changes in appetite in patients with MDD.LimitationsThe study is limited by the cross-sectional design without an intervention.ConclusionsOur results reveal potentially mood-enhancing effects of ghrelin in fasting individuals that exceed associations with metabolic state ratings. These associations with circulating neuropeptides might help explain anti-depressive effects of fasting interventions and could complement conventional treatments in patients with melancholic MDD.Graphical abstract

show abstract

Section: Introductioncontrasting

confidence: 60%

“…Plasma ghrelin levels rise before eating and decrease post-meal (Cummings et al, 2001), indicating that ghrelin plays a role in meal initiation. In accordance, a recent metaanalysis showed a positive correlation between blood levels of ghrelin and subjective levels of hunger in healthy adults (Anderson et al, 2023).…”

Section: Introductionsupporting

confidence: 60%

Ghrelin is associated with an elevated mood after an overnight fast in depression

Fahed,

Schulz,

Klaus

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…On the other hand, appetite is closely related to appetite hormones. Ghrelin, which is an orexigenic hormone primarily released by the stomach, is associated with perceptions of hunger in humans [36]. A small-sized randomized study showed that synthetic human acyl ghrelin improved cardiac output in patients with heart failure and reduced ejection fraction (HFrEF) [37].…”

Section: Discussionmentioning

confidence: 99%

Appetite Predicts Long-Term Clinical Outcomes in Patients with Acute Myocardial Infarction

Ishibashi,

Sakakura,

Ikeda

et al. 2023

JCM

View full text Add to dashboard Cite

Background: Recently, the nutritional status of patients has drawn attention in an aging society. Early studies have reported that nutritional status is related to long-term outcomes in patients with acute myocardial infarction (AMI). However, it is not necessarily simple to evaluate the nutritional status of patients with AMI. We hypothesized that appetite before discharge can be a predictor for long-term adverse cardiovascular events in patients with AMI. This retrospective study aimed to investigate whether appetite is related to long-term adverse outcomes in patients with AMI. Methods: This study included 1006 patients with AMI, and divided them into the good appetite group (n = 860) and the poor appetite group (n = 146) according to the percentage of the dietary intake on the day before discharge. Major adverse cardiac events (MACE), which were defined as a composite of all-cause death, non-fatal MI, and re-admission for heart failure, were set as the primary outcome. Results: The median follow-up duration was 996 days, and a total of 243 MACE was observed during the study period. MACE was more frequently observed in the poor appetite group than in the good appetite group (42.5% versus 21.0%, p < 0.001). In the multivariate COX hazard model, poor appetite was significantly associated with MACE (Hazard ratio 1.698, 95% confidence interval 1.243–2.319, p < 0.001) after controlling for multiple confounding factors. Conclusion: Appetite at the time of discharge was significantly associated with long-term clinical outcomes in patients with AMI. Patients with poor appetite should be carefully followed up after discharge from AMI.

show abstract

“…Moreover, age and sex may affect ghrelin secretion. In adults, the DAG levels are higher in women than in men ( 23 ), although other studies demonstrated similar total ghrelin levels between male and female newborns ( 24 , 25 ).…”

Section: Expression Secretion and Metabolism Of Ghrelinmentioning

confidence: 93%

Role of ghrelin in promoting catch-up growth and maintaining metabolic homeostasis in small-for-gestational-age infants

Zhang,

Liu,

Gao

et al. 2024

Front. Pediatr.

View full text Add to dashboard Cite

Small-for-gestational age (SGA) has been a great concern in the perinatal period as it leads to adverse perinatal outcomes and increased neonatal morbidity and mortality, has an impact on long-term health outcomes, and increases the risk of metabolic disorders, cardiovascular, and endocrine diseases in adulthood. As an endogenous ligand of the growth hormone secretagotor (GHS-R), ghrelin may play an important role in regulating growth and energy metabolic homeostasis from fetal to adult life. We reviewed the role of ghrelin in catch-up growth and energy metabolism of SGA in recent years. In addition to promoting SGA catch-up growth, ghrelin may also participate in SGA energy metabolism and maintain metabolic homeostasis. The causes of small gestational age infants are very complex and may be related to a variety of metabolic pathway disorders. The related signaling pathways regulated by ghrelin may help to identify high-risk groups of SGA metabolic disorders and formulate targeted interventions to prevent the occurrence of adult dwarfism, insulin resistance-related metabolic syndrome and other diseases.

show abstract

Endogenous Ghrelin Levels and Perception of Hunger: A Systematic Review and Meta-Analysis

Cited by 6 publications

References 93 publications

Ghrelin is associated with an elevated mood after an overnight fast in depression

Ghrelin is associated with an elevated mood after an overnight fast in depression

Appetite Predicts Long-Term Clinical Outcomes in Patients with Acute Myocardial Infarction

Role of ghrelin in promoting catch-up growth and maintaining metabolic homeostasis in small-for-gestational-age infants

Contact Info

Product

Resources

About