Endogenous opiates: 1991

Olson, Gayle A.; Olson, Richard D.; Kastin, Abba J.

doi:10.1016/0196-9781(92)90036-3

Cited by 46 publications

(8 citation statements)

References 419 publications

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“…Endogenous opioid peptides are known to play a physiological role in vertebrate reproduction (Olson et al, ). Modulatory effect of β‐endorphin (β‐EP), an opioid peptide derived from a polypeptide proopiomelanocortin on gonadotropin‐releasing hormone (GnRH) and Luteinizing hormone (LH) is reported in mammals.…”

mentioning

confidence: 99%

β‐Endorphin‐induced Inhibition of Vitellogenic Follicular Growth in the Fish Oreochromis mossambicus: Evidence for Opioidergic Mediation of Ovarian Stress Response

Chabbi

Ganesh

2013

J. Exp. Zool.

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The opioid peptide β-endorphin (β-EP) is known to play modulatory role in vertebrate reproduction. The objective of the present study was to determine the influence of β-EP and the opioid receptor antagonist naltrexone (NALT) on follicular development in normal, and stressed female tilapia Oreochromis mossambicus. Administration of 4 µg β-EP, but not 0.5 or 1.5 µg β-EP daily for 22 days caused a significant reduction in the mean GSI, HSI, and number of Stage IV (vitellogenic) follicles compared to experimental controls during the prespawning phase of the ovarian cycle. Furthermore, the Stage V (vitellogenic) follicles were completely absent during the prespawning phase concomitant with the significantly lower serum levels of estradiol and cortisol in 4 µg β-EP treated fish compared to experimental controls. On the other hand, exposure of the fish to mild acute stressors for 22 days caused changes in the ovary similar to that of high dose of β-EP, whereas administration of NALT attenuated these effects. The results reveal that β-EP exerts inhibitory effect on the vitellogenic follicular growth through the suppression of ovarian steroidogenesis. The study provides evidence for the opioidergic mediation of the ovarian stress response for the first time in fish.

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mentioning

confidence: 99%

β‐Endorphin‐induced Inhibition of Vitellogenic Follicular Growth in the Fish Oreochromis mossambicus: Evidence for Opioidergic Mediation of Ovarian Stress Response

Chabbi

Ganesh

2013

J. Exp. Zool.

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“…Subsequent cleavage of the targetor-spacer moiety finally releases the active peptide. Leu-Enkephalin Analog Since the discovery of endogenous peptides with opiate activity [612], many potential roles have been identified for these substances [613,614]. Possible therapeutic applications could extend from treatment of opiate dependence to numerous other CNS-mediated dysfunctions.…”

Section: Molecular Packagingmentioning

confidence: 98%

“…Possible therapeutic applications could extend from treatment of opiate dependence to numerous other CNS-mediated dysfunctions. Opioid peptides are implicated in regulating neuroendocrine activity [615][616][617], motor behavior [618], seizure threshold [619,620], feeding and drinking [621], mental disorders [613,622], cognitive functions [613,623], cardiovascular functions [624,625], gastrointestinal functions [613,626], and sexual behavior and development [614]. However, analgesia remains their best known role, and it is commonly used to evaluate endogenous opioid peptide activity.…”

Section: Molecular Packagingmentioning

confidence: 99%

Retrometabolism‐Based Drug Design and Targeting

Bodor

Buchwald

2010

Burger's Medicinal Chemistry and Drug Discovery

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Retrometabolic drug design (RMDD) approaches are systematic methodologies aimed to design safe compounds with an improved therapeutic index. RMDDs thoroughly integrate structure– activity and structure‐metabolism considerations into the entire design process and incorporate two major concepts aimed to design soft drugs and chemical delivery systems, respectively. Soft drugs (SDs) are new, active therapeutic agents designed to undergo predictable metabolism resulting in inactive metabolites after exerting their desired therapeutic effect(s). Chemical delivery systems (CDSs) are biologically inert molecules that provide enhanced and targeted delivery of an active drug to a particular organ or site through a designed sequential metabolism that involves several steps. Here, we present a comprehensive review including a general overview of the RMDD principles and a large number of specific examples from various pharmacological areas, including many recent developments, to illustrate RMDD concepts. Whenever possible, the rationale for the design as well as the pharmacokinetic and pharmacodynamic properties of the new therapeutic agents are briefly summarized and compared to those of the other compounds used in the same field.

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“…Endogenous opioid peptides have been shown to be involved in the regulation of several physiological functions, including reproduction, in different vertebrates Facchinetti et al, 1993;Faletti et al, 1999;Ganesh & Yajurvedi, 2003;Leadem & Kalra, 1985;Olson et al, 1992;Polzonetti-Magni et al, 1994;Zerani & Gobbetti, 1992).…”

Section: Introductionmentioning

confidence: 99%

The opioid peptide dynorphin suppresses pituitary‐ovary axis in the tilapia Oreochromis mossambicus

Vijayalaxmi

Ganesh

2020

Journal of Fish Biology

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The opioid peptides are involved in the regulation of neuroendocrine functions in vertebrates. Nonetheless, the influence of an opioid peptide, dynorphin A (DYN), on reproduction in fish is understudied. The aim of this work was to study the influence of DYN on the pituitary‐ovary axis in Oreochromis mossambicus. Daily injections (ip) of 250 μg DYN kg−1 body weight for 22 days during the ovarian cycle caused a reduction in the intensity and the per cent area of luteinizing hormone (LH) immunoreactive content in the proximal pars distalis region of the pituitary gland compared with an intense immunostaining in time‐matched controls. In the ovary, DYN treatment caused a decrease in the number of stage I (previtellogenic) follicles compared with time‐matched controls. No difference was observed in the number of stage IV (vitellogenic) follicles among different experimental groups, whereas the numbers of stage II and stage III follicles (previtellogenic) were higher in DYN‐treated fish than in time‐matched controls. Nonetheless, there was a reduction in the number of stage V (preovulatory) follicles in DYN‐treated fish compared with time‐matched controls. Taken together, these results indicate that DYN exerts an inhibitory effect on follicular recruitment at the late vitellogenic stage, through the suppression of LH secretion in fish.

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Endogenous opiates: 1991

Cited by 46 publications

References 419 publications

β‐Endorphin‐induced Inhibition of Vitellogenic Follicular Growth in the Fish Oreochromis mossambicus: Evidence for Opioidergic Mediation of Ovarian Stress Response

β‐Endorphin‐induced Inhibition of Vitellogenic Follicular Growth in the Fish Oreochromis mossambicus: Evidence for Opioidergic Mediation of Ovarian Stress Response

Retrometabolism‐Based Drug Design and Targeting

The opioid peptide dynorphin suppresses pituitary‐ovary axis in the tilapia Oreochromis mossambicus

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